Primary Hyperparathyroidism: Clinicai Presentation and Factors Influencing Clinical Management

1989 ◽  
Vol 18 (3) ◽  
pp. 631-646 ◽  
Author(s):  
David A. Heath
2011 ◽  
pp. 171-178
Author(s):  
Joel T. Adler ◽  
Rebecca S. Sippel ◽  
Herbert Chen

2021 ◽  
Vol 7 (1) ◽  
pp. 74-84
Author(s):  
Robina Ogendo

Purpose: Cryptococcal meningitis is one of the most common and lethal opportunistic infections among human immune virus infected clients/patients before initiation of antiretroviral therapy. It is majorly associated to morbidity and early mortality among human immunodeficiency virus infected patients in resource limited countries. The main objective of this study was to investigate the factors influencing clinical management of cryptococcal meningitis in adults among health care providers at two referral hospitals in Kisumu County, Kenya. Methodology: A cross-sectional study using quantitative approach was used targeting 119 health care providers. Collection of data was through pretested self- administered questionnaires to examine factors influencing clinical management of cryptococcal meningitis. Data obtained was analyzed using the statistical package for social science version 25. Descriptive analysis was done using frequencies, percentages and means. Inferential analysis was conducted using bivariate logistic regression to determine relationships among the variables, p-values of at or below 0.05 were considered statistically significant. Results: The major factor associated positively with clinical management of cryptococcal meningitis was the acknowledgement by the health care providers that the world health organization guidelines lead to a better patient outcome (97%, n=113) and inadequate supplies and resources to facilitate management (78%, n=90) was the major factor associated negatively. Health care providers with an experience of five years or less were 40% more likely to agree that the factors were influencing clinical management of cryptococcal meningitis in contrast to those with an experience of six years or more (OR: 0.6; 95%CI: 0.1 – 0.74; p=0.04). Unique contribution to theory, practice and policy:  The clinical management of cryptococcal meningitis in adults in the study area is majorly negatively influenced by inadequate supplies and resources to facilitate the process of management. The study recommends that the policy makers in the County government of Kisumu and the two hospital management teams need to scale up a timely and constant provision of adequate resources, facilities and supplies, which will promote effective clinical management of cryptococcal meningitis in the study area


2017 ◽  
Vol 87 (1) ◽  
pp. 97-102 ◽  
Author(s):  
Reto M. Kaderli ◽  
Philipp Riss ◽  
Angelika Geroldinger ◽  
Andreas Selberherr ◽  
Christian Scheuba ◽  
...  

Author(s):  
R. J. Elbin ◽  
Tracey Covassin ◽  
Caitlin Gallion ◽  
Anthony P. Kontos

Identifying factors that influence the risk and recovery from sport-related concussion (SRC) has become an important part of the clinical management of the injury. Consensus statements and clinical anecdotes have suggested several factors (i.e., history of migraine headaches) that may increase risk or lead to a protracted recovery from SRC. In the current paper, we will present evidence supporting primary and secondary risk factors listed in current consensus statements and relevant literature on emerging factors proposed to influence SRC risk and recovery.


1986 ◽  
Vol 10 (4) ◽  
pp. 555-563 ◽  
Author(s):  
Clive S. Grant ◽  
Jon A. van Heerden ◽  
J. William Charboneau ◽  
E. Meredith James ◽  
Carl C. Reading

1999 ◽  
Vol 17 (1) ◽  
pp. 15-21 ◽  
Author(s):  
M.M Idu ◽  
J Buth ◽  
W.C.J Hop ◽  
Ph Cuypers ◽  
E.D.W.M van de Pavoordt ◽  
...  

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A179-A180
Author(s):  
Alexis Roberto Yamane Laforteza ◽  
Michael Lim Villa

Abstract Background: Acute pancreatitis secondary to hypercalcemia is may be the initial presentation of a patient with primary hyperparathyroidism. However, because of its infrequency as a cause of pancreatitis, it can be easily missed during clinical management. Clinical Case: A 56-year old woman initially presented with epigastric pain with radiation to the back. She had no previous comorbidities, did not drink alcohol, and had no previous history of cholelithiasis, nephrolithiasis nor pathologic fractures. The diagnosis was confirmed by an elevated serum lipase level (59117 U/L, reference interval (RI): 73–393 U/L) and contrast-enhanced MRI findings suggestive of acute pancreatitis with hemorrhagic component in the pancreatic body and tail. Hypercalcemia was documented on two separate occasions during her confinement with a serum total calcium level of 10.5 mg/dL (RI: 8.5–10.1 mg/dL) and an ionized calcium level of 1.45 mmol/L (RI: 1.09–130 mmol/L), however, no further workup was done at that time. She was managed conservatively and was sent home with plans to do an ERCP and possible laparoscopic cholecystectomy once her condition had stabilized. However, she had recurrence of the epigastric pain about one month after her initial episode. Her serum lipase showed an interval increase from her last result (1426 U/L from 933 U/L) and contrast-MRI now showed the development of areas of walled-off necrosis in the body and tail of the pancreas. Serum ionized calcium was again elevated (2.17 mmol/L); she also had an elevated intact PTH level (780.6 pg/ml, RI: 18.5–88.0 pg/ml). Parathyroid SPECT-CT showed a sestamibi-avid lesion inferoposterior to the right thyroid lobe, indicating a probable parathyroid adenoma. She was given 1 dose of Denusomab 120 mg subcutaneously and started on Calcitonin nasal spray 200 IU twice a day. She underwent ultrasound-guided drainage of the pancreatic necrosis and was subsequently discharged. Due to difficulty in procurement of the Calcitonin nasal spray, she was maintained on Cinacalcet 30 mg/tablet, 1 tablet once a day upon discharge with plans to undergo parathyroidectomy once she was had fully recovered from her pancreatitis. Conclusion: Primary hyperparathyroidism should always be considered when hypercalcemia is noted during the clinical management of acute pancreatitis. Reference: Misgar RA, Bhat MH, Rather TA, Masoodi SR, Wani AI, Bashir MI, Wani MA, Malik AA. Primary hyperparathyroidism and pancreatitis. J Endocrinol Invest. 2020 Oct;43(10):1493–1498.


2016 ◽  
Vol 25 ◽  
pp. 82-87 ◽  
Author(s):  
Fabio Medas ◽  
Enrico Erdas ◽  
Alessandro Longheu ◽  
Luca Gordini ◽  
Giuseppe Pisano ◽  
...  

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