Organ Preservation in Multimodality Therapy of Head and Neck Cancer

1991 ◽  
Vol 5 (4) ◽  
pp. 713-724 ◽  
Author(s):  
Susan Urba ◽  
Gregory T. Wolf
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Organ Preservation ◽  
Multimodality Therapy

scholarly journals The role of infection in the morbidity and mortality of patients with head and neck cancer undergoing multimodality therapy

Cancer ◽  
1991 ◽  
Vol 67 (3) ◽  
pp. 716-721 ◽  
Author(s):  
Maha Hussain ◽  
Julie A. Kish ◽  
Lawrence Crane ◽  
Ahmed Uwayda ◽  
Glen Cummings ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Multimodality Therapy ◽  
Morbidity And Mortality

Daily concurrent chemoradiotherapy with docetaxel (DOC) and cisplatin (CDDP) using superselective intra-arterial infusion via superficial temporal artery for T3 and T4 head and neck cancer: Possibility of organ preservation in advanced head and neck cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e17020-e17020
Author(s):  
K. Mitsudo ◽  
T. Shigetomi ◽  
H. Nishiguchi ◽  
T. Fukui ◽  
N. Yamamoto ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Lymph Node ◽  
Head And Neck ◽  
Neck Cancer ◽  
Organ Preservation ◽  
Cervical Lymph Node ◽  
Superficial Temporal Artery ◽  
Temporal Artery ◽  
Advanced Head ◽  
Concurrent Radiotherapy

e17020 Background: Superselective intra-arterial chemotherapy via a superficial temporal artery (HFT method) has become feasible for daily concurrent radiotherapy and chemotherapy for head and neck cancer. We used this novel method for head and neck cancer, and evaluated its efficacy. Treatment consisted of superselective intra-arterial infusions (docetaxel total 60 mg/m2, cisplatin total 100 mg/m2) and concurrent radiotherapy (total 40 Gy) for 4 weeks as preoperative therapy. Thirty-five patients with stage III and IV oral cancer underwent surgery after this treatment, of whom pathological complete response (CR) was obtained in 31 (88.6%). In this study, the possibility of organ preservation in cases of advanced head and neck cancer was evaluated based on this result. Methods: Eligibility included T3 or T4 squamous cell carcinoma of head and neck. Treatment consisted of superselective intra-arterial infusions (docetaxel, total 60 mg/m2, cisplatin, total 150 mg/m2) and concurrent radiotherapy (total 60 Gy) for 6 weeks. Organ preservation was demonstrated in cases when the biopsy specimen of the primary lesion showed grade 3 (non-viable tumor cells present) or grade 4 (no tumor cells present) after the completion of all treatments. Results: Thirty two patients (21 male and 11 female) were eligible for evaluation. A relapse was detected in 11 cases (34.4%): primary sites, 7 cases (21.9%); cervical lymph node and distant metastasis, 2 cases (6.3%); primary site and distant metastasis, 1 case (3.1%); cervical lymph node, 1 case (3.1%). Seven patients (21.9%) died. The Kaplan-Meier method was used to estimate the 3-year and 5-year survival rates, which were 81.3% and 78.1%, respectively, and the 3-year and 5-year locoregional control rates, which were 68.8% and 64.5%, respectively. No major complications such as cerebral infarctions or other neurological complications developed in any patient. Conclusions: These results of the present study demonstrate that this is a promising new treatment strategy for advanced head and neck cancer, thus contributing to patients’ QOL. No significant financial relationships to disclose.

scholarly journals Salvage Surgery in Head and Neck Cancer

2021 ◽  
pp. 233-246
Author(s):  
Stijn van Weert ◽  
Sat Parmar ◽  
C. René Leemans
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Organ Preservation ◽  
Salvage Surgery ◽  
Transoral Robotic Surgery ◽  
Shared Decision ◽  
Surgery Complications

AbstractSalvage surgery (SS) in head and neck cancer is considered a last resort treatment after failure of organ preservation treatments. It offers challenges to the patients and the surgeon. The outcome of SS is often uncertain in terms of survival and quality of life. This paper offers an overview of evolution in SS, tumor and patient factors to be considered, challenges in reconstructive surgery, complications of SS and the changing landscape with regard to increasing incidence of human papillomavirus positive tumours, the role of transoral robotic surgery, the importance of multidisciplinary management and shared decision making.

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