Effects of oxandrolone and L-glutamine on body weight, body cell mass, and body fat in patients with HIV infection-preliminary analysis

Nutrition ◽  
1997 ◽  
Vol 13 (3) ◽  
pp. 279
Author(s):  
A. Fisher ◽  
M. Abbaticola
1995 ◽  
Vol 172 (3) ◽  
pp. 896-900 ◽  
Author(s):  
John F. Aloi ◽  
Ashok Vaswani ◽  
Linda Russo ◽  
Mary Sheehan ◽  
Edith Flaster

1967 ◽  
Vol 55 (2) ◽  
pp. 202-221 ◽  
Author(s):  
Björn Lindholm

ABSTRACT The body cell mass (BCM) was estimated from determinations of the total exchangeable potassium (Ke) in 66 patients with severe bronchial asthma requiring long-term treatment with daily doses of glucocorticoids equivalent to 25–75 mg of cortisone. Thirty subjects had been treated with cortisone for more than six years (2–12 years) prior to the present study. The remaining thirty-six patients were studied at the beginning of the cortisone treatment period. Twenty-two patients from both groups were followed during more than two years of daily cortisone therapy by repeated, paired Ke-determinations. Ke was determined by the isotope dilution technique. In all, 297 such determinations were performed by oral administration of 42K, allowing the isotope to equilibrate for 45 hours. The initial body content of Ke in male and female subjects with or without several years of previous cortisone therapy did not differ from normal subjects, when related to body weight and age. A statistical analysis revealed a significant increase in the total exchangeable potassium of both male and female subjects during treatment with cortisone. None of the patients showed significantly decreasing Ke-values during the longitudinal study. Body weight showed a covariation with Ke but did not, on an average, increase significantly with time. Cortisone induced osteoporosis was found in twelve subjects. Taken as a group, these subjects showed normal values of Ke, when related to body weight and age. Apparently, bone atrophy can develop during cortisone treatment without concomitant atrophy of the BCM.


2000 ◽  
Vol 88 (3) ◽  
pp. 944-956 ◽  
Author(s):  
Carrie P. Earthman ◽  
James R. Matthie ◽  
Phyllis M. Reid ◽  
Ingeborg T. Harper ◽  
Eric Ravussin ◽  
...  

The maintenance of body cell mass (BCM) is critical for survival in human immunodeficiency virus (HIV) infection. Accuracy of bioimpedance for measuring change (Δ) in intracellular water (ICW), which defines BCM, is uncertain. To evaluate bioimpedance-estimated ΔBCM, the ICW of 21 weight-losing HIV patients was measured before and after anabolic steroid therapy by dilution (total body water by deuterium − extracellular water by bromide) and bioimpedance. Multiple-frequency modeling- and dilution-determined ΔICW did not differ. The ΔICW was predicted poorly by 50-kHz parallel reactance, 50-kHz impedance, and 200 − 5-kHz impedance. The ΔICW predicted by 500 − 5-kHz impedance was closer to, but statistically different from, dilution-determined ΔICW. However, the effect of random error on the measurement of systematic error in the 500 − 5-kHz method was 12–13% of the average measured ΔICW; this was nearly twice the percent difference between obtained and threshold statistics. Although the 500 − 5-kHz method cannot be fully rejected, these results support the conclusion that only the multiple-frequency modeling approach accurately monitors ΔBCM in HIV infection.


Maturitas ◽  
1995 ◽  
Vol 22 (3) ◽  
pp. 268
Author(s):  
J.F. Aloia ◽  
A. Vaswani ◽  
L. Russo ◽  
M. Sheehan ◽  
E. Flaster

2005 ◽  
Vol 19 (4) ◽  
pp. 216-223 ◽  
Author(s):  
Stephen J. Ferrando ◽  
Judith G. Rabkin ◽  
Shu-Hsing Lin ◽  
Martin McElhiney

2005 ◽  
Vol 16 (4) ◽  
pp. 307-313 ◽  
Author(s):  
Stephan Klauke ◽  
Harald Fischer ◽  
Armin Rieger ◽  
Lukas Frühauf ◽  
Schlomo Staszewski ◽  
...  

AIDS wasting syndrome results in loss of lean body mass and body cell mass. This 12-week, open-label study used bioelectrical impedance analysis to measure body composition changes in 24 patients with AIDS wasting syndrome receiving recombinant human growth hormone (r-hGH). The primary endpoint was percentage monthly change in body weight before/after r-hGH. Secondary endpoints included change from baseline in body composition (bioelectrical impedance analysis), isometric strength and CD4+count. Twenty patients completed the study: r-hGH resulted in mean weight gains (+2.7%, P=0.146), and significant increases in mean body cell mass (+8.0%, P=0.0211), lean body mass (+4.8%, P=0.0373) and water (+5.5%, P<0.023). Body fat decreased throughout, but not significantly. r-hGH was generally well tolerated; the most frequent adverse events were fever (7.3%) and diarrhoea (6.3%). Thus, bioelectrical impedance analysis can detect improved body cell mass independent of changes in body weight resulting from r-hGH treatment in patients with AIDS wasting syndrome.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Till Ittermann ◽  
Marcello R. P. Markus ◽  
Martin Bahls ◽  
Stephan B. Felix ◽  
Antje Steveling ◽  
...  

AbstractPrevious studies on the association between thyroid function and body composition are conflicting and showed strong differences across age groups. Our aim was to clarify age-specific associations of serum thyroid-stimulating hormone (TSH) levels with markers of body composition including body mass index (BMI), waist circumference, fat mass (FM), fat-free mass (FFM) and body cell mass (BCM). We used data from two independent population-based cohorts within the framework of the Study of Health in Pomerania. The study population included 5656 individuals aged 20 to 90 years. Markers of body composition were measured by bioelectrical impedance analysis. Serum TSH levels were significantly positively associated with BMI (β = 0.16; 95% confidence interval [CI]: 0.06 to 0.27), waist circumference (β = 0.35; 95% CI: 0.08 to 0.62) and FM (β = 0.32; 95% CI: 0.12 to 0.52), but not with FFM and BCM. Interaction analysis revealed positive associations of serum TSH levels with BMI, waist circumference, FM, FFM and BCM in individuals older than 60 years, while no such associations were observed in younger individuals. We demonstrated that lower serum TSH levels were accompanied with lower values of BMI, waist circumference, FM, FFM, and BCM in the elderly, while no such associations were observed in younger individuals.


2018 ◽  
Vol 64 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Ana Paula Signori Urbano ◽  
Ligia Yukie Sassaki ◽  
Mariana de Souza Dorna ◽  
Paula Torres Presti ◽  
Maria Antonieta de Barros Leite Carvalhaes ◽  
...  

Summary Objective: The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. Method: This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], a1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. Results: The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). Conclusion: PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent.


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