545P A retrospective study on prognostic value of preoperative neutrophil/lymphocyte ratio in patients with primary small cell carcinoma of the esophagus

Abstract Background: Growing evidence indicates that several inflammatory biomarkers may predict survival in patients with malignant tumors. The aim of this study is to evaluate the prognostic value of pretreatment biomarkers in patients with primary small-cell carcinoma of the esophagus（PSCCE）. Methods: There were 73 PSCCE patients enrolled between January 2009 and December 2017 at the Affiliated Cancer Hospital of Zhengzhou University. The total lymphocyte counts (TLC), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) prior to anticancer therapy were collected as inflammation biomarkers. The cut-off value was determined by Receiver operating characteristic (ROC). The Kaplan–Meier method was utilized to analysis overall survival (OS). Cox proportional hazards regression was used to identify univariate and multivariate prognostic factors. Results: Univariate analysis showed that high NLR group(hazard ratio (HR) ＝1.685; 95% CI: 1.001–2.838; P＝0.047) and high PLR group (hazard ratio (HR) ＝1.716; 95% CI: 1.039–2.834; P＝0.033) were associated with poor OS, and TLC was not correlated with OS. On multivariate analysis, high PLR(hazard ratio (HR) ＝1.751; 95% CI: 1.042–2.945; P＝0.035) was an independent prognostic factor of unfavorable OS. Conclusions: Pre-treatment PLR and NLR are correlated with OS. These biomarkers are easily accessible, cost effective, and can serve as a marker to identify high-risk patients for further designing personalized treatment and predicting treatment outcomes.

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Clinical Significance of Preoperative Neutrophil Lymphocyte Ratio versus Platelet Lymphocyte Ratio in Patients with Small Cell Carcinoma of the Esophagus

The Scientific World JOURNAL ◽

10.1155/2013/504365 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 19

Author(s):

Ji-Feng Feng ◽

Ying Huang ◽

Qiang Zhao ◽

Qi-Xun Chen

Keyword(s):

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Predictive Factor ◽

Prognostic Significance ◽

Small Cell ◽

Survival Prediction ◽

Carcinoma Of The Esophagus ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Platelet Lymphocyte Ratio

Recent studies have shown that the presence of systemic inflammation correlates with poor survival in various of cancers. The aim of this study was to determine the prognostic values of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in patients with small cell carcinoma of the esophagus (SCCE). Preoperative NLR and PLR were evaluated in 43 patients with SCCE from January 2001 to December 2010. The prognostic significance of both markers was then determined by both uni- and multivariate analytical methods. Receiver operating characteristic (ROC) curves were also plotted to verify the accuracy of NLR and PLR for survival prediction. Patients with PLR ≥150 had significantly poorer (relapse-free survival) RFS and (overall survival) OS compared to patients with PLR <150. However, RFS or OS did not differ according to NLR categories (<3.5 and ≥3.5). The areas under the curve (AUC) indicated that PLR was superior to NLR as a predictive factor. The results of the present study conclude that PLR is superior to NLR as a predictive factor in patients with SCCE.

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