P-218 - The role of mood stabilizers in the management of therapy for bipolar affective disorder

Psychosocial Interventions ◽

Mood Stabilizers ◽

Psychotic Illness ◽

Early Admission ◽

Outreach Workers

This chapter deals with the other major psychotic illness, bipolar affective disorder. Bipolar disorder poses a difficult question for outreach workers, as patients are often well recovered between episodes—so should persisting outreach be provided? We report very good results in severe bipolar disorder where continuity of care has paid off. The chapter also deals with theories of causation and classification. The section on treatment identifies the importance of early admission in hypomania, the use of mood stabilizers, and the value of identifying and agreeing on relapse signatures. It also confirms the value of working hard to strengthen the therapeutic relationship and of psychosocial interventions such as psycho-education. Long-term work with these patients brings home just how persistent and disabling the depressive phases can be.

Bipolar affective disorder in the postnatal period: investigating the role of sleep

Bipolar Disorders ◽

10.1111/j.1399-5618.2010.00845.x ◽

2010 ◽

Vol 12 (5) ◽

pp. 568-578 ◽

Cited By ~ 13

Author(s):

Justin L C Bilszta ◽

Denny Meyer ◽

Anne E Buist

Keyword(s):

Affective Disorder ◽

Postnatal Period

Bipolar affective disorder and anticonvulsant mood stabilizers

Primary Care Psychiatry ◽

10.1185/135525701750384455 ◽

2001 ◽

Vol 7 (2) ◽

pp. 49-53 ◽

Author(s):

Karine A. N. MacRitchie ◽

I. Nicol Ferrier

Keyword(s):

Affective Disorder ◽

Mood Stabilizers

Dysregulation of ion fluxes in bipolar affective disorder

Acta Neuropsychiatrica ◽

10.1017/s0924270800035468 ◽

2000 ◽

Vol 12 (3) ◽

pp. 81-85 ◽

Author(s):

H.C.R. Grunze ◽

J. Langosch ◽

C. Normann ◽

D. Rujescu ◽

B. Amann ◽

...

Keyword(s):

Bipolar Disorder ◽

Potassium Conductance ◽

Mood Stabilizer ◽

Mechanisms Of Action ◽

Ion Fluxes ◽

Mood Stabilizers ◽

Calcium Antagonism ◽

Sodium Calcium

ABSTRACTBipolar disorder has attracted numerous research from different neurobiological angles. This review will summarize selected findings focusing on the role of disturbed transmem-braneous ion fluxes. Several mood stabilizers exhibit a distinct profile including effects on sodium, calcium and potassium conductance. In summary, some decisive mechanisms of action as calcium antagonism and modulation of potassium currents may play a crucial role in the success of any given mood stabilizer in bipolar disorder.

Are second-generation antipsychotics as effective as mood stabilizers for maintenance treatment of bipolar affective disorder?

Evidence-Based Practice ◽

10.1097/01.ebp.0000545125.02749.6b ◽

2018 ◽

Vol 21 (5) ◽

pp. 15

Author(s):

Sarah Swofford ◽

Gregory Cejas

Keyword(s):

Affective Disorder ◽

Maintenance Treatment ◽

Second Generation ◽

Mood Stabilizers ◽

Second Generation Antipsychotics

Shoplifting in the Mentally Ill: The role of bipolar affective disorder and mental retardation

Medicine Science and the Law ◽

10.1258/rsmmsl.45.4.317 ◽

2005 ◽

Vol 45 (4) ◽

pp. 317-320 ◽

Author(s):

Rachel S Y Cheng ◽

Candy Lin ◽

Marcella L Y Fok ◽

Chi-Ming Leung

Keyword(s):

Mental Retardation ◽

Affective Disorder ◽

Mentally Ill ◽

Matched Control ◽

Psychiatric Patients ◽

Mental Illnesses ◽

Control Group ◽

University Department

This study explores shoplifting behaviour in mentally ill patients, and evaluates the association between shoplifting and different mental illnesses in a local Chinese population. A comparison is made between shoplifting offenders and a matched control group of non-offenders among the psychiatric patients registered at a university department of psychiatry. Major depression, bipolar affective disorder (BAD) and mental retardation (MR) are the most common diagnoses among mentally ill shoplifters, while patients with a diagnosis of BAD or MR are at higher risk of committing an offence than patients with other diagnoses. Bipolar affective disorder has not been described as a risk factor for shoplifting behaviour in the psychiatric literature. Such a possibility should be seriously considered in the psychiatric assessment of shoplifting cases.

Association between bipolar affective disorder, use of antidepressants and osteoporosis

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh200811096c ◽

2021 ◽

pp. 96-96

Author(s):

Mina Cvjetkovic-Bosnjak ◽

Milana Okanovic ◽

Sanja Pavlovic ◽

Olga Zivanovic ◽

Vesna Vasic ◽

...

Keyword(s):

Affective Disorder ◽

Depressive Episode ◽

Selective Serotonin Reuptake Inhibitors ◽

Mood Stabilizer ◽

Mood Stabilizers ◽

Mineral Density ◽

Control Groups ◽

Significant Difference ◽

Prevalence Of Osteoporosis

Introduction/Objective. Osteoporosis is one of the most common comorbid disorders in depressive mood disorder. The aim of this study was to assess the association between use of antidepressants and osteoporosis in patients with bipolar affective disorder (BPAD). Methods. The study included 73 inpatients, aged 50-72 years, male and female, hospitalized with depressive episode of BPAD from 2016-2020 at Clinic of psychiatry, Clinical centre of Vojvodina, devided in two groups: a) first group (40) was treated with selective serotonin reuptake inhibitors (SSRIs) in combination with mood stabilizer (lithium carbonate/lamotrigine), b) second group (33) was treated with mood stabilizer only. Study included two control groups, too. Clinical measurements of bone mineral density at lumbal spine and hip was made using dual energy X-ray absortiometry. CrossLaps and level of calcium and vitamin D were collected from blood sample. Data was analyzed by Analysis of variance and Kruskal-Wallis test. Results. Osteoporosis was registered in 25% of patients in the first group and in 18% of patients in second group, while osteopenia was observed within 40% of patients in the first group and in 37% of patients in the second group. There was significant difference in value of CrossLaps, and level of 25 (OH) D vitamin between control groups and first two groups, as well as in prevalence of osteoporosis and osteopenia. Conclusion. Depressive episode in BPAD is connected with higher prevalence of osteoporosis. Patients treated with SSRIs have higher prevalence of osteoporosis than patients treated with mood stabilizers only

Considerations on assisted resilience and individualized therapy in bipolar affective disorder, with a clinical case exemplification

Medicine and Pharmacy Reports ◽

10.15386/cjmed-443 ◽

2015 ◽

Vol 88 (4) ◽

pp. 462-467 ◽

Author(s):

Alexandra Bolos

Keyword(s):

Bipolar Disorder ◽

Affective Disorder ◽

Clinical Case ◽

Indirect Costs ◽

Economic Consequences ◽

Case Presentation ◽

Affective Symptoms ◽

Psychosocial Consequences

Morbidity, mortality and economic consequences of bipolar affective disorder are very important to be evaluated because many of the costs entailed by this psychiatric disorder come from indirect costs due to inadequate diagnosis and treatment and from the characteristics of the affective symptoms itself. Psychotherapy focuses on diagnosis and the newest pharmacotherapy determines a decreasing of the morbidity of the disorder and also of its social and economic burden . However, more studies are necessary, with more heterogeneous patients, to find more predictors regarding the psychosocial consequences and to find more information about the prognosis of the bipolar disorder.In this context, in this paper we discuss the role of assisted resilience and the individualization of the therapy of bipolar affective disorder, especially that the resilience must be seen as a continuum and can be used anytime and in any situation, according to the theory of Geanellos. This idea is reflected in a case presentation of a patient with the diagnosis of bipolar disorder.

Antiepileptics as mood stabilizers

European Psychiatry ◽

10.1016/s0924-9338(11)71909-5 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 199-199

Author(s):

G. Danevski

Keyword(s):

Bipolar Disorder ◽

Affective Disorder ◽

First Generation ◽

Mood Stabilizers ◽

Emergency Psychiatry ◽

Antiepileptic Agents ◽

Methodological Challenges ◽

Two Generations ◽

Bipolar Affective Disorders

The field of bipolar affective disorders research now immence methodological challenges, some of which have only recently become obvious.It has become more clear that bipolar affective disorder should be viewed longitudinally rather than in terms of individual episodes. As result of these methodological challenges, more have been far a few mood stabilizers approwed for use in bipolar disorder. Lithium was the gold standard of treatment for bipolar disorder, but a number of studies over the past several decades shown that many drugs with antiepileptic properties are effective in the treatment of some patients with bipolar affective disorder, especially for those whose disorder inadequately responds to lithium, and those who are intolerant of treatment with lithium. These antiepileptic agents include two generations of drugs: cabamazepin and valproate as first generation, and lamotrigine, gabapentine and topiramate as second generation of mood stabilising antiepileptic agents. In this article are rewiew the pharmacological properties and their efficacy in the treatment of bipolar disorder.A series of 32 patients with bipolar affective disorder was reported. All patients were supervized in the Emergency psychiatry service in Psychiatric Hospital Skopje, as the greatest and most important psychiatric institution in Macedonia. We also summarise use of these agents in combination with other psychotropics.