P.1.e.025 Altered white matter tracts in subjects at high genetic risk of schizophrenia by diffusion tensor tractography

2007 ◽  
Vol 17 ◽  
pp. S295
Author(s):  
S.Y. Yoo ◽  
B.B. Koo ◽  
S.R. Yeon ◽  
C.H. Choi ◽  
D.H. Kang ◽  
...  
2008 ◽  
Vol 108 (4) ◽  
pp. 775-781 ◽  
Author(s):  
Feng Wang ◽  
Tao Sun ◽  
Xing-Gang Li ◽  
Na-Jia Liu

Object The aim of this study was to use diffusion tensor tractography (DTT) to define the 3D relationships of the uncinate fasciculus, anterior commissure, inferior occipitofrontal fasciculus, inferior thalamic peduncle, and optic radiation and to determine the positioning landmarks of these white matter tracts. Methods The anatomy was studied in 10 adult human brain specimens. Brain DTT was performed in 10 healthy volunteers. Diffusion tensor tractography images of the white matter tracts in the temporal stem were obtained using the simple single region of interest (ROI) and multi-ROIs based on the anatomical knowledge. Results The posteroinferior insular point is the anterior extremity of intersection of the Heschl gyrus and the inferior limiting sulcus. On the inferior limiting sulcus, this point is the posterior limit of the optic radiation, and the temporal stem begins at the limen insulae and ends at the posteroinferior insular point. The distance from the limen insulae to the tip of the temporal horn is just one third the length of the temporal stem. The uncinate fasciculus comprises the core of the anterior temporal stem, behind which the anterior commissure and the inferior thalamic peduncle are located, and they occupy the anterior third of the temporal stem. The inferior occipitofrontal fasciculus passes through the entire temporal stem. The most anterior extent of the Meyer loop is located between the anterior tip of the temporal horn and the limen insulae. Most of the optic radiation crosses the postmedian two thirds of the temporal stem. Conclusions On the inferior limiting sulcus, the posteroinferior insular point is a reliable landmark of the posterior limit of the optic radiations. The limen insulae, anterior tip of the temporal horn, and posteroinferior insular point may be used to localize the white matter fibers of the temporal stem in analyzing magnetic resonance imaging or during surgery.


2008 ◽  
Vol 106 (2-3) ◽  
pp. 132-139 ◽  
Author(s):  
S MUNOZMANIEGA ◽  
G LYMER ◽  
M BASTIN ◽  
D MARJORAM ◽  
D JOB ◽  
...  

NeuroImage ◽  
2008 ◽  
Vol 39 (1) ◽  
pp. 62-79 ◽  
Author(s):  
I. Nigel C. Lawes ◽  
Thomas R. Barrick ◽  
Vengadasalam Murugam ◽  
Natalia Spierings ◽  
David R. Evans ◽  
...  

NeuroImage ◽  
2009 ◽  
Vol 46 (2) ◽  
pp. 530-541 ◽  
Author(s):  
Simon W. Davis ◽  
Nancy A. Dennis ◽  
Norbou G. Buchler ◽  
Leonard E. White ◽  
David J. Madden ◽  
...  

2019 ◽  
Author(s):  
Justin C. Hayes ◽  
Katherine L Alfred ◽  
Rachel Pizzie ◽  
Joshua S. Cetron ◽  
David J. M. Kraemer

Modality specific encoding habits account for a significant portion of individual differences reflected in functional activation during cognitive processing. Yet, little is known about how these habits of thought influence long-term structural changes in the brain. Traditionally, habits of thought have been assessed using self-report questionnaires such as the visualizer-verbalizer questionnaire. Here, rather than relying on subjective reports, we measured habits of thought using a novel behavioral task assessing attentional biases toward picture and word stimuli. Hypothesizing that verbal habits of thought are reflected in the structural integrity of white matter tracts and cortical regions of interest, we used diffusion tensor imaging and volumetric analyses to assess this prediction. Using a whole-brain approach, we show that word bias is associated with increased volume in several bilateral language regions, in both white and grey matter parcels. Additionally, connectivity within white matter tracts within an a priori speech production network increased as a function of word bias. These results demonstrate long-term structural and morphological differences associated with verbal habits of thought.


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