P.4.b.012 Assessment of striatal dopamine release in obsessive-compulsive disorder using positron emission tomography

2009 ◽  
Vol 19 ◽  
pp. S603
Author(s):  
M. Figee ◽  
F. de Vries ◽  
N. Vulink ◽  
D. Cath ◽  
T. van der Doef ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Obsessive Compulsive Disorder ◽  
Dopamine Release ◽  
Striatal Dopamine ◽  
Emission Tomography ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Positron Emission ◽  
Striatal Dopamine Release

scholarly journals Striatal Dopamine Release in Response to Morphine: A [11C]Raclopride Positron Emission Tomography Study in Healthy Men

2019 ◽  
Vol 86 (5) ◽  
pp. 356-364 ◽  
Author(s):  
Primavera A. Spagnolo ◽  
Alane Kimes ◽  
Melanie L. Schwandt ◽  
Ehsan Shokri-Kojori ◽  
Shantalaxmi Thada ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dopamine Release ◽  
Striatal Dopamine ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Healthy Men ◽  
Positron Emission ◽  
Striatal Dopamine Release

Bilateral Orbitomedial Leucotomy for Obsessive–Compulsive Disorder: A Single-Case Study Using Positron Emission Tomography

2001 ◽  
Vol 35 (5) ◽  
pp. 684-690 ◽  
Author(s):  
Perminder Sachdev ◽  
Julian Trollor ◽  
Alexandra Walker ◽  
Wei Wen ◽  
Michael Fulham ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Obsessive Compulsive Disorder ◽  
Single Case ◽  
Anterior Cingulate ◽  
Emission Tomography ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Caudate Head ◽  
Positron Emission ◽  
Medial Cortex

Objective: The objective of this report is to correlate the clinical outcome of neurosurgery for obsessive–compulsive disorder (OCD) with regional cerebral glucose metabolic changes. Clinical picture: The patient was a 37-year-old female patient with severe and intractable OCD. Treatment: The patient was treated with bilateral stereotactic lesions in the frontal white matter superior to the orbito-medial cortex. Outcome: She had a remarkable improvement in her obsessive–compulsive symptoms, which was sustained up to 3 years of follow up. A positron emission tomography (PET) scan performed 18 days after surgery demonstrated an obvious reduction of metabolism in the caudate head, anterior cingulate and orbital, medial and lateral prefrontal cortices and the thalamus. At 1 year postsurgery, metabolic rate was still reduced in the anterior cingulate gyrus, caudate and thalamus compared with preoperative baseline. The patient demonstrated no long-term cognitive effects of the surgery. Conclusions: This case supports some of the cortical-subcortical circuit dysfunction models of OCD and argues for the further evaluation of neurosurgery for the treatment of a severe and intractable disorder.

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