P.1.e.027 Serotonin -1A receptor binding in the dorsal raphe nucleus is associated with hippocampal grey matter volume

2011 ◽  
Vol 21 ◽  
pp. S318-S319
Author(s):  
C. Kraus ◽  
A. Hahn ◽  
M. Savli ◽  
A. Höflich ◽  
P. Baldinger ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Grey Matter ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Grey Matter Volume ◽  
Serotonin 1A Receptor ◽  
Matter Volume ◽  
Dorsal Raphé

Serotonin-1A receptor binding and Reward-dependent Activation are associated within the Human Dorsal Raphe Nucleus as revealed by PET-fMRI.

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. S176 ◽  
Author(s):  
R. Lanzenberger ◽  
A. Hahn ◽  
C. Windischberger ◽  
W. Wadsak ◽  
A. Holik ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Serotonin 1A Receptor ◽  
Dorsal Raphé

5-HT1A receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia

2012 ◽  
Vol 103 (2) ◽  
pp. 367-372 ◽  
Author(s):  
Yang-Hee Jung ◽  
Seung-Hwan Kwon ◽  
Sa-Ik Hong ◽  
Sung-Ok Lee ◽  
Sun-Yeou Kim ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Cinnamomum Cassia ◽  
Dorsal Raphé

Serotonin actions within the prelimbic cortex induce anxiolysis mediated by serotonin 1a receptors

2018 ◽  
Vol 33 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Paula SM Yamashita ◽  
Daiane S Rosa ◽  
Christopher A Lowry ◽  
Helio Zangrossi
Keyword(s):  
Prefrontal Cortex ◽  
Dorsal Raphe Nucleus ◽  
Behavioral Responses ◽  
Anxiolytic Effect ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Serotonin 1A Receptor ◽  
Serotonin 1A Receptors ◽  
Escape Behaviors ◽  
Dorsal Raphé

Background: Serotonin plays an important role in the regulation of anxiety, acting through complex modulatory mechanisms within distinct brain structures. Serotonin can act through complex negative feedback mechanisms controlling the neuronal activity of serotonergic circuits and downstream physiologic and behavioral responses. Administration of serotonin or the serotonin 1A receptor agonist, (±)-8-hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT), into the prefrontal cortex, inhibits anxiety-like responses. The prelimbic area of the prefrontal cortex regulates serotonergic neurons within the dorsal raphe nucleus and is involved in modulating anxiety-like behavioral responses. Aims: This study aimed to investigate the serotonergic role within the prelimbic area on anxiety- and panic-related defensive behavioral responses. Methods: We investigated the effects of serotonin within the prelimbic area on inhibitory avoidance and escape behaviors in the elevated T-maze. We also extended the investigation to serotonin 1A, 2A, and 2C receptors. Results: Intra-prelimbic area injection of serotonin or 8-OH-DPAT induced anxiolytic effects without affecting escape behaviors. Previous administration of the serotonin 1A receptor antagonist, WAY-100635, into the prelimbic area counteracted the anxiolytic effects of serotonin. Neither the serotonin 2A nor the serotonin 2C receptor preferential agonists, (±)-2,5-dimethoxy-4-iodoamphetamine (DOI) and 6-chloro-2-(1-piperazinyl) pyrazine (MK-212), respectively, affected behavioral responses in the elevated T-maze. Conclusion: Facilitation of serotonergic signaling within the prelimbic area of rats induced an anxiolytic effect in the elevated T-maze test, which was mediated by local serotonin 1A receptors. This inhibition of anxiety-like defensive behavioral responses may be mediated by prelimbic area projections to neural systems controlling anxiety, such as the dorsal raphe nucleus or basolateral amygdala.

Buspirone-induced changes in the serotonergic and non-serotonergic cells in the dorsal raphe nucleus of rats

2010 ◽  
Vol 473 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Ali Jahanshahi ◽  
Lee Wei Lim ◽  
Harry W.M. Steinbusch ◽  
Veerle Visser-Vandewalle ◽  
Yasin Temel
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Induced Changes ◽  
Dorsal Raphé
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