P.2.015 The effects of early life stress on nucleus accumbens GABAA receptor function and cocaine mediated behaviour

2014 ◽  
Vol 24 ◽  
pp. S42-S43
Author(s):  
S. Mitchell ◽  
E.P. Maguire ◽  
B.G. Gunn ◽  
L. Cunningham ◽  
M.B. Herd ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Gabaa Receptor ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Receptor Function

S.07.05 The effects of early life stress on nucleus accumbens GABAA receptor function and cocaine mediated behaviour

2014 ◽  
Vol 24 ◽  
pp. S119 ◽  
Author(s):  
S.J. Mitchell ◽  
E.P. Maguire ◽  
B.G. Gunn ◽  
L. Cunningham ◽  
M.B. Herd ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Gabaa Receptor ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Receptor Function

scholarly journals Early-life stress alters sleep structure and the excitatory-inhibitory balance in the nucleus accumbens in aged mice

2019 ◽  
Vol 132 (13) ◽  
pp. 1582-1590
Author(s):  
Ting Wang ◽  
Hong-Li Wang ◽  
Rui Liu ◽  
Han Wang ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Sleep Structure ◽  
Aged Mice

scholarly journals Early Life Stress Associated With Increased Striatal N-Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass, and Behavioral Correlates

2018 ◽  
Vol 2 ◽  
pp. 247054701876845 ◽  
Author(s):  
Jeremy D. Coplan ◽  
Dunyue Lu ◽  
Alexander M. El Sehamy ◽  
Cheuk Tang ◽  
Andrea P. Jackowski ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Nucleus Accumbens ◽  
Body Mass ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Hippocampal Volume ◽  
Corticotropin Releasing Factor ◽  
Resonance Spectroscopy ◽  
Stress Markers

Introduction Using proton magnetic resonance spectroscopy imaging, the effects of early life stress on nonhuman primate striatal neuronal integrity were examined as reflected by N-acetyl aspartate (NAA) concentrations. NAA measures were interrogated through examining their relationship to previously documented early life stress markers—cerebrospinal fluid corticotropin-releasing factor concentrations, hippocampal volume, body mass, and behavioral timidity. Rodent models of depression exhibit increases in neurotrophic effects in the nucleus accumbens. We hypothesized that rearing under conditions of early life stress (variable foraging demand, VFD) would produce persistent elevations of NAA concentrations (in absolute or ratio form) in ventral striatum/caudate nucleus (VS/CN) with altered correlation to early life stress markers. Methods Eleven bonnet macaque males reared under VFD conditions and seven age-matched control subjects underwent proton magnetic resonance spectroscopy imaging during young adulthood. Voxels were placed over VS/CN to capture nucleus accumbens. Cisternal cerebrospinal fluid corticotropin-releasing factor concentrations, hippocampal volume, body mass, and response to a human intruder had been previously determined. Results VFD-reared monkeys exhibited significantly increased NAA/creatine concentrations in right VS/CN in comparison to normally reared controls, controlling for multiple comparisons. In comparison to controls, VFD cerebrospinal fluid corticotropin-releasing factor concentrations were directly associated with right VS/CN absolute NAA. Left hippocampal volume was inversely associated with left VS/CN NAA/creatine in VFD reared but not in controls. Disruption of a normative inverse correlation between left VS/CN NAA and body mass was noted in VFD. Only non-VFD subjects exhibited a direct relationship between timidity response to an intruder and right VS/CN NAA. Conclusion Early life stress produced persistent increases in VS/CN NAA, which demonstrated specific patterns of association (or lack thereof) to early life stress markers in comparison to non-VFD subjects. The data are broadly consistent with a stable nonhuman primate phenotype of anxiety and mood disorder vulnerability whereby in vivo indicators of neuronal integrity, although reduced in hippocampus, are increased in striatum. The findings may provide a catalyst for further studies in humans and other species regarding a reciprocal hippocampal/nucleus accumbens relationship in affective disorders.

scholarly journals Reduced nucleus accumbens reactivity and adolescent depression following early-life stress

Neuroscience ◽  
2013 ◽  
Vol 249 ◽  
pp. 129-138 ◽  
Author(s):  
B. Goff ◽  
D.G. Gee ◽  
E.H. Telzer ◽  
K.L. Humphreys ◽  
L. Gabard-Durnam ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Life Stress ◽  
Early Life ◽  
Adolescent Depression ◽  
Early Life Stress

scholarly journals Early life stress alters opioid receptor mRNA levels within the nucleus accumbens in a sex-dependent manner

2019 ◽  
Vol 1710 ◽  
pp. 102-108 ◽  
Author(s):  
Liza Chang ◽  
Stacey L. Kigar ◽  
Jasmine H. Ho ◽  
Amelia Cuarenta ◽  
Haley C. Gunderson ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Opioid Receptor ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Mrna Levels ◽  
Dependent Manner ◽  
Receptor Mrna

scholarly journals Early Life Stress Promotes Heroin Seeking But Does Not Alter the Excitability of Insular Pyramidal Cells Targeting the Nucleus Accumbens

2021 ◽  
Vol 15 ◽  
Author(s):  
Jonna M. Leyrer-Jackson ◽  
Paula F. Overby ◽  
Erin K. Nagy ◽  
M. Foster Olive
Keyword(s):  
Nucleus Accumbens ◽  
Adverse Childhood Experiences ◽  
Life Stress ◽  
Early Life ◽  
Pyramidal Neurons ◽  
Early Life Stress ◽  
Self Administration ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Seeking Behavior

A number of retrospective studies have demonstrated adverse childhood experiences are associated with increased vulnerability to substance use disorders, including opioid use disorders (OUDs). These adverse childhood experiences, also referred to as early life stress (ELS), can be modeled in laboratory animals by various paradigms including limited bedding and nesting (LBN) procedures. Studies using rodent models of ELS have been shown to recapitulate various aspects of OUDs, including relapse propensity and perseverance of drug-seeking behavior. In the current study, we utilized the LBN paradigm to explore potential effects on heroin self-administration, extinction, and relapse-like behaviors in male and female rats. We also utilized in vitro whole-cell electrophysiology to examine the effects of LBN and repeated heroin administration on the excitability of pyramidal neurons in the anterior insular cortex (AIC) projecting to the nucleus accumbens core (NAc), as recent studies suggest that this circuit may mediate various aspects of OUDs and may be compromised as a result of either ELS or OUDs. We observed that compared to control animals, rats exposed to LBN conditions during postnatal days 2–9 showed increased breakpoints for heroin self-administration under a progressive ratio schedule of reinforcement, impaired extinction of heroin-seeking behavior, and increased reinstatement of heroin-seeking behavior induced by heroin-associated cues. No effect of LBN rearing conditions were observed on the acquisition and maintenance of heroin self-administration, and no sex differences in heroin intake were observed. LBN and control reared animals showed no differences in the excitability of AIC-NAc pyramidal neurons, but animals treated with repeated heroin showed decreased excitability of these neurons through a significant increase in rheobase and reduction in action potentials induced by depolarizing currents. Together, these results suggest that ELS exposure produces exacerbations of heroin seeking behavior without parallel effects on AIC-NAc excitability, although heroin itself reduces the excitability of these neurons.

scholarly journals Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats

2016 ◽  
Vol 41 (12) ◽  
pp. 2851-2861 ◽  
Author(s):  
Candace R Lewis ◽  
Ryan M Bastle ◽  
Tawny B Manning ◽  
Sarah M Himes ◽  
Paulette Fennig ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Male Rats ◽  
Self Administration
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