In vitro inhibition of simvastatin metabolism, a HMG-CoA reductase inhibitor in human and rat liver by bergamottin, a component of grapefruit juice

In Vitro Inhibition ◽

189 Gene expression changes in rat liver induced by two hypolipidemic drugs; A PPAR-α agonist and a HMG-CoA reductase inhibitor and diethylhexyl phthalate using affymetrix genechip® technology

Toxicology Letters ◽

10.1016/s0378-4274(03)90188-3 ◽

2003 ◽

Vol 144 ◽

pp. s54

Author(s):

N. Simecek ◽

J.P. Wood ◽

S.L. Margrett ◽

C.J. Waterfield ◽

H. Thakkar ◽

...

Keyword(s):

Gene Expression ◽

Rat Liver ◽

Reductase Inhibitor ◽

Affymetrix Genechip ◽

Hmg Coa Reductase ◽

Diethylhexyl Phthalate ◽

Coa Reductase ◽

Hypolipidemic Drugs

The HMG-CoA reductase inhibitor simvastatin suppresses human testicular testosterone synthesis in vitro by a selective inhibitory effect on 17-ketosteroid-oxidoreductase enzyme activity

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/0960-0760(91)90333-z ◽

1991 ◽

Vol 38 (4) ◽

pp. 465-468 ◽

Cited By ~ 27

Author(s):

Anthony G.H. Smals ◽

Jos J.A.M. Weusten ◽

Theo J. Benraad

Keyword(s):

Enzyme Activity ◽

Reductase Inhibitor ◽

Inhibitory Effect ◽

Hmg Coa Reductase ◽

Coa Reductase ◽

Testosterone Synthesis

Pharmacological concentrations of the HMG-COA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta -amyloid peptide em in vitro em and in patients

Frontiers in Bioscience ◽

10.2741/a739 ◽

2002 ◽

Vol 7 (1) ◽

pp. a50-59 ◽

Cited By ~ 1

Author(s):

Joseph D Buxbaum

Keyword(s):

Reductase Inhibitor ◽

Beta Amyloid ◽

Amyloid Peptide ◽

Hmg Coa Reductase ◽

Beta Amyloid Peptide ◽

An HMG-CoA Reductase Inhibitor, Cerivastatin, Suppresses Growth of Macrophages Expressing Matrix Metalloproteinases and Tissue Factor In Vivo and In Vitro

Circulation ◽

10.1161/01.cir.103.2.276 ◽

2001 ◽

Vol 103 (2) ◽

pp. 276-283 ◽

Cited By ~ 366

Author(s):

Masanori Aikawa ◽

Elena Rabkin ◽

Seigo Sugiyama ◽

Sami J. Voglic ◽

Yoshihiro Fukumoto ◽

...

Keyword(s):

Matrix Metalloproteinases ◽

Tissue Factor ◽

Reductase Inhibitor ◽

Hmg Coa Reductase ◽

Pharmacological studies on NK-104, a novel potent HMG-CoA reductase inhibitor (1): Inhibitory effects on the enzyme (in vitro) and sterol synthesis (in vivo) in rats and hypolipidemic effects in dogs

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)46359-2 ◽

1995 ◽

Vol 67 ◽

pp. 99

Author(s):

Shunji Nakagwa ◽

Taro Aoki ◽

Hideo Suzuki ◽

Taro Tamaki ◽

Yasushi Wada ◽

...

Keyword(s):

Reductase Inhibitor ◽

Sterol Synthesis ◽

Inhibitory Effects ◽

Hmg Coa Reductase ◽

Pharmacological Studies ◽

Effect of NK-104, a new synthetic HMG-CoA reductase inhibitor, on triglyceride secretion and fatty acid oxidation in rat liver

Life Sciences ◽

10.1016/s0024-3205(99)00390-2 ◽

1999 ◽

Vol 65 (14) ◽

pp. 1493-1502 ◽

Cited By ~ 7

Author(s):

Kyosuke Yamamoto ◽

Naoki Todaka ◽

Hiromi Goto ◽

Anura P. Jayasooriya ◽

Masanobu Sakono ◽

...

Keyword(s):

Fatty Acid ◽

Fatty Acid Oxidation ◽

Rat Liver ◽

Reductase Inhibitor ◽

Acid Oxidation ◽

Hmg Coa Reductase ◽

Triglyceride Secretion ◽

Molecular rationale delineating the role of lycopene as a potent HMG-CoA reductase inhibitor: in vitro and in silico study

Natural Product Research ◽

10.1080/14786419.2015.1108977 ◽

2015 ◽

Vol 30 (18) ◽

pp. 2111-2114 ◽

Cited By ~ 17

Author(s):

Sahir Sultan Alvi ◽

Danish Iqbal ◽

Saheem Ahmad ◽

M. Salman Khan

Keyword(s):

In Silico ◽

Reductase Inhibitor ◽

Hmg Coa Reductase ◽

In Silico Study ◽

In vitro antitumor activity of cerivastatin, a novel and potent HMG-CoA reductase inhibitor

FEBS Letters ◽

10.1016/s0014-5793(01)02736-3 ◽

2001 ◽

Vol 503 (2-3) ◽

pp. 219-220 ◽

Cited By ~ 8

Author(s):

Wojciech Feleszko ◽

Izabela Mlynarczuk ◽

Dominika Nowis

Keyword(s):

Antitumor Activity ◽

Reductase Inhibitor ◽

Hmg Coa Reductase ◽

Grapefruit juice (GFJ) has a small effect on lovastatin plasma HMG-CoA reductase inhibitor (HMGRI) profiles

Clinical Pharmacology & Therapeutics ◽

10.1016/s0009-9236(99)80128-3 ◽

1999 ◽

Vol 65 (2) ◽

pp. 149-149 ◽

Cited By ~ 2

Author(s):

J ROGERS ◽

J VEGA ◽

J ZHAO ◽

L LIU ◽

R AMIN ◽

...

Keyword(s):

Reductase Inhibitor ◽

Grapefruit Juice ◽

Hmg Coa Reductase ◽

In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/s00210-015-1169-3 ◽

2015 ◽

Vol 389 (1) ◽

pp. 17-32 ◽

Cited By ~ 12

Author(s):

Bihter Atil ◽

Evelyn Berger-Sieczkowski ◽

Johanna Bardy ◽

Martin Werner ◽

Martin Hohenegger

Keyword(s):

Reductase Inhibitor ◽

Atp Binding ◽

Hmg Coa Reductase ◽

Atp Binding Cassette Transporter ◽

Coa Reductase ◽

Atp Binding Cassette