A single dose oral bioavailability and bioequivalance study of gamma-linolenic acid in healthy volunteers

1997 ◽  
Vol 57 (2) ◽  
pp. 218
Keyword(s):  
Single Dose ◽  
Healthy Volunteers ◽  
Linolenic Acid ◽  
Oral Bioavailability ◽  
Gamma Linolenic Acid ◽  
Dose Oral

Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: A single-dose, randomized, open-label, two-way crossover study

2007 ◽  
Vol 29 (5) ◽  
pp. 900-908 ◽  
Author(s):  
Anna Solans ◽  
Marcel·lí Carbó ◽  
Juana Peña ◽  
Teresa Nadal ◽  
Iñaki Izquierdo ◽  
...  
Keyword(s):  
Single Dose ◽  
Crossover Study ◽  
Healthy Volunteers ◽  
Oral Bioavailability ◽  
Open Label ◽  
Influence Of Food

scholarly journals The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Chuleegone Sornsuvit ◽  
Darunee Hongwiset ◽  
Songwut Yotsawimonwat ◽  
Manatchaya Toonkum ◽  
Satawat Thongsawat ◽  
...  
Keyword(s):  
Single Dose ◽  
Healthy Volunteers ◽  
Pharmacokinetic Study ◽  
Oral Bioavailability ◽  
Pharmacokinetic Parameters ◽  
Open Label ◽  
Blood Samples ◽  
Rapid Absorption ◽  
The Mean

The present study aimed to determine the pharmacokinetic parameters and bioavailability of silymarin 140 mg SMEDDS formulation. An open-label, single-dose pharmacokinetic study was conducted. Twelve healthy volunteers were included in the study. After the volunteers had fasted overnight for 10 h, a single-dose generic silymarin 140 mg SMEDDS soft capsule was administered. Then 10 ml blood samples were taken at 0.0, 0.25, 0.50, 0.75, 1.0, 1.33, 1.67, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 10.0, and 12.0 h. The plasma silybin concentrations were analyzed using validated LC-MS/MS. The pharmacokinetic parameters were analyzed and calculated. The pharmacokinetic parameters were calculated after silymarin had been administered as a single capsule. The mean (range) Cmax was 812.43 (259.47–1505.47) ng/ml at 0.80 (0.25–1.67) h (tmax). The mean (range) AUC0-t and AUC0-inf were 658.80 (268.29–1045.01) ng.h/ml and 676.98 (274.10–1050.96) ng.h/ml, respectively. The mean ke and t1/2 were 0.5386 h-1 and 1.91 h, respectively. The silymarin SMEDDS formulation soft capsule showed rapid absorption and high oral bioavailability.

Plasma Concentration and CNS Effects of Ca Antagonists Darodipine and Nimodipine after Single-Dose Oral Administration to Healthy Volunteers

1999 ◽  
Vol 40 (3) ◽  
pp. 158-170 ◽  
Author(s):  
W.G. Sannita ◽  
S. Garbarino ◽  
D. Gesino ◽  
S. Massimilla ◽  
C. Ogliastro
Keyword(s):  
Single Dose ◽  
Plasma Concentration ◽  
Oral Administration ◽  
Healthy Volunteers ◽  
Dose Oral ◽  
Cns Effects

Dose-Proportional Pharmacokinetics of Risedronate on Single-Dose Oral Administration to Healthy Volunteers

2000 ◽  
Vol 40 (3) ◽  
pp. 258-265 ◽  
Author(s):  
David Y. Mitchell ◽  
Rachelle A. Eusebio ◽  
Nancy A. Sacco-Gibson ◽  
Karen A. Pallone ◽  
Sandra C. Kelly ◽  
...  
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Healthy Volunteers ◽  
Dose Oral ◽  
Dose Proportional
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