A comparison of extrahepatic lipogenesis from a small glucose meal in obob and gold thioglucose obese mice fed low- or high-fat diets with or without the addition of δ22-5β-taurocholenic acid

2000 ◽  
Vol 11 (2) ◽  
pp. 87-93
Author(s):  
G.Richard Jansen
Keyword(s):  
Obese Mice ◽  
High Fat ◽  
Gold Thioglucose ◽  
High Fat Diets ◽  
Fat Diets

Adipose tissue metabolism of obese mice on standard and high-fat diets

1961 ◽  
Vol 201 (1) ◽  
pp. 23-26 ◽  
Author(s):  
Serene Lochaya ◽  
Nicole Leboeuf ◽  
Jean Mayer ◽  
Bernard Leboeuf
Keyword(s):  
Adipose Tissue ◽  
Obese Mice ◽  
High Fat ◽  
Carbon Incorporation ◽  
Adipose Tissue Metabolism ◽  
Glucose Carbon ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets ◽  
Fat Feeding

Adipose tissue metabolism in vitro was studied, after substitution for several weeks of synthetic low-carbohydrate, high-fat (saturated or unsaturated) diets for the standard chow diet, in obese hyperglycemic mice and in their nonobese littermates. In tissue from nonobese mice fed the high-fat diets, glucose metabolism to CO2 and to fatty acids was diminished in the absence of added hormone, while glucose carbon incorporation to glyceride-glycerol was increased. Under insulin (0.1 unit/ml) stimulation, total glucose uptake was relatively decreased by the diets, as was glucose metabolism to CO2, to fatty acids, and to glycogen; however, glucose carbon incorporation to glyceride-glycerol was unaltered. Under epinephrine stimulation, the sum of glucose carbon recovery was less after high-fat feeding. No effect of high-fat feeding was detected on base-line rates of free fatty acid release nor on the effects of insulin or epinephrine on this process. No differences were found between the effects of saturated- or unsaturated-fat diets on any parameters. The metabolism of adipose tissue from obese mice was slightly, if at all, affected by high-fat feeding. These results are discussed in reference to the normal adaptation to low-carbohydrate, high-fat diets and to the metabolic abnormalities present in obese hyperglycemic mice.

Vigna nakashimae Extract Prevents Hepatic Steatosis in Obese Mice Fed High-Fat Diets

2014 ◽  
Vol 17 (12) ◽  
pp. 1322-1331 ◽  
Author(s):  
Yonghae Son ◽  
Min Kyung Jang ◽  
Myeong Ho Jung
Keyword(s):  
Hepatic Steatosis ◽  
Obese Mice ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals High-Fat Diets Containing Different Types of Fatty Acids Modulate Gut-Brain Axis in Obese Mice

2021 ◽  
Author(s):  
Yinan Hua ◽  
Jingyi Shen ◽  
Rong Fan ◽  
Rong Xiao ◽  
Weiwei Ma
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
High Fatty Acid ◽  
Metabolic Responses ◽  
Obese Mice ◽  
High Fat ◽  
High Fat Diets ◽  
Different Types ◽  
Pufa Group ◽  
Fat Diets

Abstract Background: Excessive consumption of high-fat diets is associated with disordered metabolic responses, which may lead to chronic diseases. High-fat diets containing different types of fatty acids lead to distinct alterations in metabolic responses of gut-brain axis. Methods: In our study, normal male C57BL/6J mice were fed to multiple high fatty acid diets (long-chain and medium-chain saturated fatty acid, LCSFA and MCSFA group; n-3 and n-6 polyunsaturated fatty acid, n-3 and n-6 PUFA group; monounsaturated fatty acid, MUFA group; trans fatty acid, TFA group) and a basic diet (control, CON group) for 19 weeks. To investigate the effects of high-fat diets on metabolic responses of gut-brain axis in obese mice, blood lipids were detected by fast gas chromatography, and related proteins in brain and intestine were detected using Western blotting, ELISA, and immunochemistry analysis. Results: All high-fat diets regardless of their fatty acid composition induced obesity, lipid disorders, intestinal barrier dysfunction, and changes in gut-brain axis related factors except basal diet in mice. For example, the protein expression of zonula occludens-1 (ZO-1) in ileum in the n-3 PUFA group was higher than those in the MCSFA and CON group (all Ps < 0.05). The expressions of insulin in hippocampus and leptin in ileum in the MCSFA group were all higher than those in other groups (all Ps < 0.05). Conclusions: The high MCSFA diet had the most effect on metabolic disorders, and the high n-3 PUFA diet had the least effect on changes in metabolism.

Expression of vitamin D hydroxylases and bone quality in obese mice consuming saturated or monounsaturated enriched high-fat diets

2018 ◽  
Vol 60 ◽  
pp. 106-115 ◽  
Author(s):  
Yang Wang ◽  
Patricia Buckendahl ◽  
Kajal Sharma ◽  
Joshua W. Miller ◽  
Sue A. Shapses
Keyword(s):  
Vitamin D ◽  
Bone Quality ◽  
Obese Mice ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

Physiologic Observations on Yellow Obesity in the Mouse

1958 ◽  
Vol 193 (3) ◽  
pp. 499-504 ◽  
Author(s):  
K. J. Carpenter ◽  
Jean Mayer
Keyword(s):  
Obese Mice ◽  
Total Lipids ◽  
High Fat ◽  
Male And Female ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Yellow Male ◽  
High Fat Diets ◽  
Exercise Activity ◽  
Fat Diets

In our colony, yellow obese mice were longer than nonobese littermates and yellow males were heavier than yellow females. Weight gain was greatest on high fat diets. If the yellow mice were given a possibility to exercise (activity cages), they lost weight. Resistance to cold was good. Fasted blood glucose levels were normal, fed levels frequently elevated in males. Yellow male and female mice showed a degree of insulin resistance; yellow males showed a marked hyperglycemic response to growth hormone, ACTH, cortisone, and glucagon. Blood total lipids were elevated in yellow mice, with the females exhibiting hypercholesterolemia. As in other forms of ‘metabolic’ obesity, blood ketones were decreased by an 18 hours fast.

scholarly journals Shift of Circadian Feeding Pattern by High-Fat Diets Is Coincident with Reward Deficits in Obese Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36139 ◽  
Author(s):  
Lidia Morales ◽  
Nuria Del Olmo ◽  
Ismael Valladolid-Acebes ◽  
Alberto Fole ◽  
Victoria Cano ◽  
...  
Keyword(s):  
Feeding Pattern ◽  
Obese Mice ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

Non-Fasting Factor VII Coagulant Activity (FVII:C) Increased by High-Fat Diet

1994 ◽  
Vol 71 (06) ◽  
pp. 755-758 ◽  
Author(s):  
E M Bladbjerg ◽  
P Marckmann ◽  
B Sandström ◽  
J Jespersen
Keyword(s):  
High Fat Diet ◽  
Fat Content ◽  
Factor Vii ◽  
Amidolytic Activity ◽  
High Fat ◽  
Low Fat Diet ◽  
Increased Risk ◽  
Coagulant Activity ◽  
High Fat Diets ◽  
Fat Diets

SummaryPreliminary observations have suggested that non-fasting factor VII coagulant activity (FVII:C) may be related to the dietary fat content. To confirm this, we performed a randomised cross-over study. Seventeen young volunteers were served 2 controlled isoenergetic diets differing in fat content (20% or 50% of energy). The 2 diets were served on 2 consecutive days. Blood samples were collected at 8.00 h, 16.30 h and 19.30 h, and analysed for triglycerides, FVII coagulant activity using human (FVII:C) or bovine thromboplastin (FVII:Bt), and FVII amidolytic activity (FVIPAm). The ratio FVII:Bt/FVII:Am (a measure of FVII activation) increased from fasting levels on both diets, but most markedly on the high-fat diet. In contrast, FVII: Am (a measure of FVII protein) tended to decrease from fasting levels on both diets. FVII:C rose from fasting levels on the high-fat diet, but not on the low-fat diet. The findings suggest that high-fat diets increase non-fasting FVII:C, and consequently may be associated with increased risk of thrombosis.

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