Determination of the proto-oncogenic role of PIM1/PIM2 kinases in male reproductive system pre-neoplastic lesions by using conditional transgenic murine models

2016 ◽  
Vol 61 ◽  
pp. S34
Author(s):  
M.P. Jiménez-García ◽  
M.J. Robles-Frias ◽  
B. Felipe-Abrio ◽  
A. Lucena-Cacace ◽  
D. Otero-Albiol ◽  
...  
Keyword(s):  
Reproductive System ◽  
Male Reproductive System ◽  
Murine Models ◽  
Neoplastic Lesions ◽  
Transgenic Murine Models

Abstract 655: Determination of the pro-oncogenic role of PIM1/PIM2 kinases in male reproductive system pre-neoplastic lesions by using conditional transgenic murine models

2016 ◽  
Author(s):  
Antonio Lucena-Cacace ◽  
Manuel P Jiménez-García ◽  
Irene Ferrer ◽  
Blanca Felipe Abrio ◽  
Eva M Verdugo-Sivianes ◽  
...  
Keyword(s):  
Reproductive System ◽  
Male Reproductive System ◽  
Murine Models ◽  
Neoplastic Lesions ◽  
Transgenic Murine Models

Protective role of caffeic acid on lambda cyhalothrin-induced changes in sperm characteristics and testicular oxidative damage in rats

2011 ◽  
Vol 28 (7) ◽  
pp. 639-647 ◽  
Author(s):  
Fatma Ben Abdallah ◽  
Hamadi Fetoui ◽  
Nassira Zribi ◽  
Feiza Fakhfakh ◽  
Leila Keskes
Keyword(s):  
Oxidative Damage ◽  
Caffeic Acid ◽  
Reproductive System ◽  
Male Fertility ◽  
Treated Group ◽  
Protective Role ◽  
Male Reproductive System ◽  
Male Rats ◽  
Lambda Cyhalothrin

The synthetic pyrethroids are expected to cause deleterious effects on most of the organs and especially on the male reproductive system. The current study was performed to assess the adverse effect of lambda cyhalothrin (LC) on reproductive organs and fertility in male rats and to evaluate the protective role of caffeic acid phenethyl ester (CAPE) in alleviating the detrimental effect of LC on male fertility. A total of 48 male rats were divided into 4 groups (12 rats each): control group received distilled water ad libitum and 1 ml of vehicle solution given intraperitoneally (i.p.); CAPE-treated group received a single i.p. dose of CAPE (10 μmol kg−1 day−1); LC-treated group received 668 ppm of LC through drinking water; and CAPE + LC-treated group received an i.p. injection of CAPE (10 μmol kg−1 day−1) 12 h before the LC administration. The experiment was conducted for 10 consecutive weeks. LC caused a significant increase in testicular malondialdehyde, catalase, superoxide dismutase, glutathione- S-transferase activities, and sperm abnormalities and a significant reduction in testicular glutathione concentration, sperm count, sperm motility, and a live sperm percentage. Conversely, treatment with CAPE improved the reduction in the sperm characteristics, LC-induced oxidative damage of testes and the testicular histopathological alterations. Results indicate that LC exerts significant harmful effects on the male reproductive system and that CAPE reduced the deleterious effects of LC on male fertility.

scholarly journals The renin-angiotensin system and male reproduction: new functions for old hormones

2003 ◽  
Vol 30 (3) ◽  
pp. 263-270 ◽  
Author(s):  
PS Leung ◽  
C Sernia
Keyword(s):  
Reproductive System ◽  
Renin Angiotensin System ◽  
Fluid Secretion ◽  
Male Reproductive System ◽  
Male Reproduction ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Acrosomal Exocytosis

The blood-borne renin-angiotensin system (RAS) is known best for its role in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, numerous tIssues show intrinsic angiotensin-generating systems that cater for specific local needs through actions that add to, or differ from, the circulating RAS. The male reproductive system has several sites of intrinsic RAS activity. Recent focus on the epididymis, by our laboratories and by others, has contributed important details about the local RAS in this tIssue. The RAS components have been localized morphologically and topographically; they have been shown to be responsive to androgens and to hypoxia; and angiotensin has been shown to influence tubular, and consequently, fluid secretion. Components of the RAS have also been found in the testis, vas deferens, prostate and semen. Angiotensin II receptors, type 1 and, to a lesser extent, type 2 are widespread, and angiotensin IV receptors have been localized in the prostate. The roles of the RAS in local processes at these sites are still uncertain and have yet to be fully elucidated, although there is evidence for involvement in tubular contractility, spermatogenesis, sperm maturation, capacitation, acrosomal exocytosis and fertilization. Notwithstanding this evidence for the involvement of the RAS in various important aspects of male reproduction, there has so far been a lack of clinical evidence, demonstrable by changes in fertility, for a crucial role of the RAS in male reproduction. However, it is clear that there are several potential targets for manipulating the activity of the male reproductive system by interfering with the locally generated angiotensin systems.

Adaptations of the short-beaked echidna Tachyglossus aculateus for sperm production, particularly in an arid environment.

2004 ◽  
Vol 26 (2) ◽  
pp. 199 ◽  
Author(s):  
RC Jones ◽  
D Djakiew ◽  
JL Dacheux
Keyword(s):  
Sperm Competition ◽  
Reproductive System ◽  
Prostate Gland ◽  
Arid Environment ◽  
Male Reproductive System ◽  
Sperm Production ◽  
Testicular Sperm ◽  
And Storage ◽  
Number Of Males

A re-examination is made of the old interpretation that the male reproductive system of the short-beaked echidna (Tachyglossus aculateus), and monotremes in general, is ?primitive?. There is an emerging concept of the significance of the male reproductive system in relation to the role of males in conception. Even though some aspects of the male reproductive system of T. aculateus may be considered primitive and impose limitations on their life style, they nevertheless display significant specializations present in the male tract of other mammals: an epididymis with the unique initial segment and a role in post-testicular sperm maturation and storage, and homologues of the prostate gland and penis. The absence of a descended testis and scrotum has not restricted the survival of T. aculateus in virtually all habitats in Australia. However, it may restrict their capacity to breed throughout the year. It is suggested that T. aculateus is also specialised for sperm competition. An estimate of the rate of spermatogenesis indicates that it is comparable with other mammals. Consequently, the size of their testes and number of extragonadal sperm compared with other mammals are indicative that they are involved in sperm competition. The cooperation involved in the formation of sperm bundles is also indicative of sperm competition. Further, the formation of ?echidna trains?, in which a number of males will follow in line behind an oestrous female indicates that there is competition between males to mate with a female.

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