Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, ganoderma lucidum

1999 ◽  
Vol 7 (9) ◽  
pp. 2047-2052 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Naoko Takahashi ◽  
Linda Hanashima ◽  
Hiroyuki Koshino ◽  
Yasuaki Esumi ◽  
...  
Keyword(s):  
Ganoderma Lucidum ◽  
Dna Polymerases ◽  
Eukaryotic Dna

Quaternary structural diversity in eukaryotic DNA polymerases: monomeric to multimeric form

2020 ◽  
Vol 66 (4) ◽  
pp. 635-655 ◽  
Author(s):  
Narottam Acharya ◽  
Prashant Khandagale ◽  
Shweta Thakur ◽  
Jugal Kishor Sahu ◽  
Bhabasha Gyanadeep Utkalaja
Keyword(s):  
Dna Polymerases ◽  
Structural Diversity ◽  
Eukaryotic Dna

Selective inhibition of the activities of both eukaryotic DNA polymerases and DNA topoisomerases by elenic acid

2002 ◽  
Vol 63 (3) ◽  
pp. 399-407 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Chikako Murakami ◽  
Keisuke Ohta ◽  
Hirosato Takikawa ◽  
Kenji Mori ◽  
...  
Keyword(s):  
Dna Polymerases ◽  
Selective Inhibition ◽  
Dna Topoisomerases ◽  
Eukaryotic Dna

Analysis of cell cycle regulation by 1-mono-O-acyl-3-O-(α-d-sulfoquinovosyl)-glyceride (SQMG), an inhibitor of eukaryotic DNA polymerases

2003 ◽  
Vol 66 (4) ◽  
pp. 541-550 ◽  
Author(s):  
Chikako Murakami ◽  
Masaharu Takemura ◽  
Hiromi Yoshida ◽  
Fumio Sugawara ◽  
Kengo Sakaguchi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Dna Polymerases ◽  
Eukaryotic Dna ◽  
Cycle Regulation

scholarly journals A new class of errant DNA polymerases provides candidates for somatic hypermutation

2001 ◽  
Vol 356 (1405) ◽  
pp. 47-51 ◽  
Author(s):  
Brigette Tippin ◽  
Myron F. Goodman
Keyword(s):  
Somatic Hypermutation ◽  
Dna Polymerases ◽  
Variable Region ◽  
Affinity Maturation ◽  
Immunoglobulin Genes ◽  
New Class ◽  
Eukaryotic Dna ◽  
Factor Governing

The mechanism of somatic hypermutation of the immunoglobulin genes remains a mystery after nearly 30 years of intensive research in the field. While many clues to the process have been discovered in terms of the genetic elements required in the immunoglobulin genes, the key enzymatic players that mediate the introduction of mutations into the variable region are unknown. The recent wave of newly discovered eukaryotic DNA polymerases have given a fresh supply of potential candidates and a renewed vigour in the search for the elusive mutator factor governing affinity maturation. In this paper, we discuss the relevant genetic and biochemical evidence known to date regarding both somatic hypermutation and the new DNA polymerases and address how the two fields can be brought together to identify the strongest candidates for further study. In particular we discuss evidence for the in vitro biochemical misincorporation properties of human Rad30B/Pol ι and how it compares to the in vivo somatic hypermutation spectra.

A conserved 3′→5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases

Cell ◽  
1989 ◽  
Vol 59 (1) ◽  
pp. 219-228 ◽  
Author(s):  
Antonio Bernad ◽  
Luis Blanco ◽  
JoséM. Lázaro ◽  
Gil Martín ◽  
Margarita Salas
Keyword(s):  
Active Site ◽  
Dna Polymerases ◽  
Eukaryotic Dna

Interactions of 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (Cidofovir) Diphosphate with DNA Polymerases α, δ and ε*

2001 ◽  
Vol 66 (11) ◽  
pp. 1698-1706 ◽  
Author(s):  
Gabriel Birkuš ◽  
Ivan Votruba ◽  
Miroslav Otmar ◽  
Antonín Holý
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerases ◽  
Competitive Inhibitor ◽  
Dna Polymerase Δ ◽  
Eukaryotic Dna

The inhibitory and/or substrate activity of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine [(S)-HPMPC, cidofovir, Vistide™] diphosphate towards eukaryotic DNA polymerases α, δ and ε* was examined. Cidofovir diphosphate is a weak competitive inhibitor of the above enzymes, approximately 3 to 7 times weaker than its adenine analogue (S)-HPMPApp. The enzymes also catalyze incorporation of (S)-HPMPC into DNA; after insertion of one (S)-HPMPC residue into DNA, another dNMP residue may incorporate. DNA polymerase δ and ε* can successively accommodate in the growing chain two (S)-HPMPC residues at the maximum, whereas pol α up to three residues.

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