Separate mapping of left and right eye activation reveals ocular dominance columns in human primary visual cortex

NeuroImage ◽  
2001 ◽  
Vol 13 (6) ◽  
pp. 785
Author(s):  
Peter Dechent ◽  
Jens Frahn
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Ocular Dominance ◽  
Ocular Dominance Columns ◽  
Left And Right

Late development of Zif268 ocular dominance columns in primary visual cortex of primates

1996 ◽  
Vol 732 (1-2) ◽  
pp. 237-241 ◽  
Author(s):  
Luiz Carlos L Silveira ◽  
Fernando Márcio G de Mátos ◽  
Alessandro Pontes-Arruda ◽  
Cristovam W Picanço-Diniz ◽  
José Agusto P Muniz
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Ocular Dominance ◽  
Late Development ◽  
Ocular Dominance Columns

scholarly journals Blockade of retinal or cortical activity does not prevent the development of callosal patches normally associated with ocular dominance columns in primary visual cortex

2021 ◽  
Vol 38 ◽  
Author(s):  
Hsueh Chung Lu ◽  
Robyn J. Laing ◽  
Jaime F. Olavarria
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Neural Activity ◽  
Single Injection ◽  
Ocular Dominance ◽  
Cell Activity ◽  
Ocular Dominance Columns ◽  
Callosal Connections ◽  
Monocular Enucleation ◽  
Physiological Evaluation

Abstract Callosal patches in primary visual cortex of Long Evans rats, normally associated with ocular dominance columns, emerge by postnatal day 10 (P10), but they do not form in rats monocularly enucleated a few days before P10. We investigated whether we could replicate the results of monocular enucleation by using tetrodotoxin (TTX) to block neural activity in one eye, or in primary visual cortex. Animals received daily intravitreal (P6–P9) or intracortical (P7–P9) injections of TTX, and our physiological evaluation of the efficacy of these injections indicated that the blockade induced by a single injection lasted at least 24 h. Four weeks later, the patterns of callosal connections in one hemisphere were revealed after multiple injections of horseradish peroxidase in the other hemisphere. We found that in rats receiving either intravitreal or cortical injections of TTX, the patterns of callosal patches analyzed in tangential sections from the flattened cortex were not significantly different from the pattern in normal rats. Our findings, therefore, suggest that the effects of monocular enucleation on the distribution of callosal connections are not due to the resulting imbalance of afferent ganglion cell activity, and that factors other than neural activity are likely involved.

scholarly journals Complete Pattern of Ocular Dominance Columns in Human Primary Visual Cortex

2007 ◽  
Vol 27 (39) ◽  
pp. 10391-10403 ◽  
Author(s):  
D. L. Adams ◽  
L. C. Sincich ◽  
J. C. Horton
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Ocular Dominance ◽  
Ocular Dominance Columns

scholarly journals Ultra-high resolution fMRI reveals origins of feedforward and feedback activity within laminae of human ocular dominance columns

2020 ◽  
Author(s):  
Gilles de Hollander ◽  
Wietske van der Zwaag ◽  
Chencan Qian ◽  
Peng Zhang ◽  
Tomas Knapen
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
High Field ◽  
Ocular Dominance ◽  
Top Down ◽  
Ultra High Field ◽  
Bottom Up ◽  
Ocular Dominance Columns ◽  
Cortical Columns ◽  
Model Free

AbstractUltra-high field MRI can functionally image the cerebral cortex of human subjects at the submillimeter scale of cortical columns and laminae. Here, we investigate both in concert, by, for the first time, imaging ocular dominance columns (ODCs) in primary visual cortex (V1) across different cortical depths. We ensured that putative ODC patterns in V1 (a) are stable across runs, sessions, and scanners located in different continents (b) have a width (∼1.3 mm) expected from post-mortem and animal work and (c) are absent at the retinotopic location of the blind spot. We then dissociated the effects of bottom-up thalamo-cortical input and attentional feedback processes on activity in V1 across cortical depth. Importantly, the separation of bottom-up information flows into ODCs allowed us to validly compare attentional conditions while keeping the stimulus identical throughout the experiment. We find that, when correcting for draining vein effects and using both model-based and model-free approaches, the effect of monocular stimulation is largest at deep and middle cortical depths. Conversely, spatial attention influences BOLD activity exclusively near the pial surface. Our findings show that simultaneous interrogation of columnar and laminar dimensions of the cortical fold can dissociate thalamocortical inputs from top-down processing, and allow the investigation of their interactions without any stimulus manipulation.Significance StatementThe advent of ultra-high field fMRI allows for the study of the human brain non-invasively at submillimeter resolution, bringing the scale of cortical columns and laminae into focus. De Hollander et al imaged the ocular dominance columns and laminae of V1 in concert, while manipulating top-down attention. This allowed them to separate feedforward from feedback processes in the brain itself, without resorting to the manipulation of incoming information. Their results show how feedforward and feedback processes interact in the primary visual cortex, highlighting the different computational roles separate laminae play.

Ocular dominance columns and local projections of layer 6 pyramidal neurons in macaque primary visual cortex

1997 ◽  
Vol 14 (2) ◽  
pp. 241-251 ◽  
Author(s):  
Anne K. Wiser ◽  
Edward M. Callaway
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Pyramidal Neurons ◽  
Ocular Dominance ◽  
Class Ii ◽  
Class I ◽  
Individual Layer ◽  
Ocular Dominance Columns ◽  
Axonal Projections ◽  
Axonal Arbors

AbstractTo study the relationship between ocular dominance columns (ODCs) and axonal projections of individual layer 6 pyramidal neurons in the primary visual cortex, neurons were intracellularly labeled with biocytin in live slices prepared from macaque monkeys that had received an intravitreal injection of tetrodotoxin (TTX). The TTX injection indirectly causes a decrease in cytochrome oxidase (CO) expression in the cortical ODCs corresponding to the treated eye (Wong-Riley & Carroll, 1984). Sections from slices with labeled layer 6 neurons were double stained for biocytin and CO, to allow visualization of neuronal processes as well as ODCs. Twenty-seven layer 6 pyramidal neurons in ODC-labeled slices were analyzed. These neurons were classified according to the criteria of Wiser and Callaway (1996). Eight of these are class I neurons, which have dense axonal projections to the monocular layer 4C. The remaining 19 are class II neurons which project primarily to the binocular layers outside 4C. Among class I neurons, two have dense axonal arbors in layer 4Cα (type Iα), one in layer 4Cβ (type Iβ), and two throughout the depth of layer 4C (type IC). None of these neurons have ODC-specific axonal arbors. The remaining three class I neurons have focused axonal projections in layers 4Cβ and 4A (type IβA). All three appear to have axonal arbors predominantly within their home ODC in layer 4C. The axonal arbors of class II neurons do not appear to relate to ODCs in any specific fashion.

Effect of monocular deprivation on NMDAR1 immunostaining in ocular dominance columns of the marmoset Callithrix jacchus

2000 ◽  
Vol 17 (3) ◽  
pp. 345-352 ◽  
Author(s):  
CAROLINE FONTA ◽  
CATHERINE CHAPPERT ◽  
MICHEL IMBERT
Keyword(s):  
Visual Cortex ◽  
Nmda Receptors ◽  
Primary Visual Cortex ◽  
Ocular Dominance ◽  
Callithrix Jacchus ◽  
Monocular Deprivation ◽  
Neuronal Tracing ◽  
Ocular Dominance Columns ◽  
Visual Activity ◽  
Cortical Afferents

We previously showed that immunoreactivity to N-Methyl-D-aspartate (NMDA) receptors in primary visual cortex of Callithrix jacchus is regulated by visual activity during the second and third postnatal months (Fonta et al., 1997). The purpose of the present study was to show that the columnar pattern of high and low NMDAR1 immunoreactivity observed in monocularly deprived animals corresponds to ocular dominance columns linked to the nondeprived and deprived eye, respectively. We compared cortical distribution of NMDAR1 receptors and the projection zones of thalamic afferents, revealed by transneuronal transport of tritiated proline, in 2-month-old, either monocularly deprived or control, marmosets. The data show that ocular dominance columns exist in 2-month-old marmosets and that a 2-week monocular deprivation by means of eyelid suture leads to a modification of the thalamo-cortical afferents organization. Experiments of neuronal tracing and immunohistochemistry performed on the same animals demonstrated that cortical domains with decreased NMDAR1 level correspond to the deprived eye columns. These investigations, coupled to the previous results, strongly suggest that the NMDA receptors, regulated by visual activity, are involved in the refining of ocular dominance columns in the primary visual cortex of juvenile marmoset.

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