Hepatocyte Growth Factor (HGF) concentration in matched samples of maternal venous blood and fetal cord venous and arterial blood: Evidence for control of fetal liver development

1998 ◽  
Vol 5 (1) ◽  
pp. 122A-122A
Author(s):  
D SOMERSET ◽  
E JAUNIAUX ◽  
A STRAIN ◽  
S AFFORD ◽  
M KILBY
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Fetal Liver ◽  
Venous Blood ◽  
Liver Development ◽  
Arterial Blood ◽  
Matched Samples ◽  
Hepatocyte Growth

Scatter factor/hepatocyte growth factor is essential for liver development

Nature ◽  
1995 ◽  
Vol 373 (6516) ◽  
pp. 699-702 ◽  
Author(s):  
Claudia Schmidt ◽  
Friedhelm Bladt ◽  
Stefanie Goedecke ◽  
Volker Brinkmann ◽  
Wolfgang Zschiesche ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Liver Development ◽  
Scatter Factor ◽  
Hepatocyte Growth

Immunolocalization of hepatocyte growth factor and its receptor (c-Met) during mouse liver development

2001 ◽  
Vol 116 (5) ◽  
pp. 453-462 ◽  
Author(s):  
Kiyoshi S. Ishikawa ◽  
Tohru Masui ◽  
Katsutoshi Ishikawa ◽  
Nobuyoshi Shiojiri
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Mouse Liver ◽  
Liver Development ◽  
Hepatocyte Growth

scholarly journals Hepatocyte growth factor as a hematopoietic regulator

Blood ◽  
1995 ◽  
Vol 85 (11) ◽  
pp. 3093-3100 ◽  
Author(s):  
T Nishino ◽  
H Hisha ◽  
N Nishino ◽  
M Adachi ◽  
S Ikehara
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Fetal Liver ◽  
Fetal Life ◽  
Cell Counts ◽  
Proliferation And Differentiation ◽  
Nonadherent Cell ◽  
Hepatocyte Growth ◽  
Synergistic Increase

Hepatocyte growth factor (HGF) was originally isolated as a mitogen for adult hepatocytes, but this cytokine is now regarded as a multi-functional factor. In the present study, we show that the mouse liver in the middle and/or late stage of the fetal life expresses both HGF and c-met (its receptor) messages. HGF and c-met mRNA are coexpressed not only in the adherent layers of fetal liver long-term cultures (FL-LTCs) and adult bone marrow long-term cultures (BM-LTCs), but also in the stromal cell lines MS-5 and PA-6. Addition of human HGF (2 and 20 ng/mL) to the LTCs enhances (1) nonadherent cell counts (ninefold in FL-LTCs and sixfold in BM-LTCs), (2) nonadherent colony-forming unit-in culture (CFU-C) counts (eightfold in FL-LTCs and fivefold in BM-LTC), and (3) cobblestone colony counts. However, HGF slightly inhibits the proliferation of stromal cells. No direct effect of HGF on freshly isolated BM and/or FL cells is found in the CFU-C assay. However, an approximately 1.5-fold synergistic increase in CFU-C counts is noted when the BM or FL cells are cocultured with HGF in the presence of interleukin-3. These findings strongly suggest that HGF plays a crucial role as a hematopoietic regulator in the proliferation and differentiation of hematopoietic progenitors.

Role of Bcl-xL in hepatocyte growth factor-elicited epithelial protection in idiopathic pulmonary fibrosis

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
S Skwarna ◽  
I Henneke ◽  
W Seeger ◽  
T Geiser ◽  
A Günther ◽  
...  
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth

Potential role of an endothelium-specific growth factor, hepatocyte growth factor, on endothelial damage in diabetes

Diabetes ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 138-142 ◽  
Author(s):  
R. Morishita ◽  
S. Nakamura ◽  
Y. Nakamura ◽  
M. Aoki ◽  
A. Moriguchi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Potential Role ◽  
Specific Growth ◽  
Endothelial Damage ◽  
Specific Growth Factor ◽  
Hepatocyte Growth

Culture of adult human islet preparations with hepatocyte growth factor and 804G matrix is mitogenic for duct cells but not for beta-cells

Diabetes ◽  
1998 ◽  
Vol 47 (1) ◽  
pp. 134-137 ◽  
Author(s):  
V. H. Lefebvre ◽  
T. Otonkoski ◽  
J. Ustinov ◽  
M. A. Huotari ◽  
D. G. Pipeleers ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Beta Cells ◽  
Human Islet ◽  
Adult Human ◽  
Duct Cells ◽  
Hepatocyte Growth
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