Perinatal exposure to diethylstilbestrol improves olfactory discrimination learning in male and female Swiss-Webster mice

2003 ◽  
Vol 80 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Sheila M Mihalick
Keyword(s):  
Discrimination Learning ◽  
Olfactory Discrimination ◽  
Perinatal Exposure ◽  
Male And Female

OLFACTORY DISCRIMINATION LEARNING IN THE VIRGINIA OPOSSUM

1966 ◽  
Vol 23 (3) ◽  
pp. 845-846 ◽  
Author(s):  
MARK W. TILLEY ◽  
JOHN H. DOOLITTLE ◽  
DONALD J. MASON
Keyword(s):  
Discrimination Learning ◽  
Olfactory Discrimination ◽  
Virginia Opossum

scholarly journals Neural Encoding in Ventral Striatum during Olfactory Discrimination Learning

Neuron ◽  
2003 ◽  
Vol 38 (4) ◽  
pp. 625-636 ◽  
Author(s):  
Barry Setlow ◽  
Geoffrey Schoenbaum ◽  
Michela Gallagher
Keyword(s):  
Discrimination Learning ◽  
Ventral Striatum ◽  
Olfactory Discrimination ◽  
Neural Encoding

Olfactory discrimination limits in gerbils

1971 ◽  
Vol 49 (3) ◽  
pp. 283-285 ◽  
Author(s):  
Anne Innis Dagg ◽  
Doug E. Windsor
Keyword(s):  
Meriones Unguiculatus ◽  
Olfactory Discrimination ◽  
Small Rodents ◽  
Male And Female

Gerbils (Meriones unguiculatus) that had been taught to distinguish between pairs of odors using a T-maze were able to distinguish between gerbils and four other species of small rodents, between male and female gerbils, between two male gerbils, between the urines of these two males when they were diluted 1 part in up to 1000 parts water, and between water and urine that was diluted 1 part in 10 000 parts water.

scholarly journals Perinatal exposure to diesel exhaust origin secondary organic aerosol induces autism-like behavior in rats

2020 ◽  
Author(s):  
Tin Tin Win Shwe ◽  
Chaw Kyi Tha Thu ◽  
Yuji Fujitani ◽  
Shinji Tsukahara ◽  
Seishiro Hirano
Keyword(s):  
Prefrontal Cortex ◽  
Diesel Exhaust ◽  
Secondary Organic Aerosol ◽  
Organic Aerosol ◽  
Female Rats ◽  
Perinatal Exposure ◽  
Male And Female ◽  
Glutamate Concentration ◽  
Immunological Markers ◽  
Male And Female Rats

Abstract Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social communication, poor social interactions and repetitive behaviors. The exact cause and mechanism of autism remains unknown. Both genetic and environmental factors may involve in ASD. In this study, we used diesel exhaust (DE) origin secondary organic aerosol (DE-SOA) as environmental pollutants. DE-SOA was generated by oxidative reaction of mixing DE with ozone. The aim of present study is to examine autism-like behaviors and related gene expressions in rats exposed to DE-SOA perinatally. Sprague-Dawley pregnant rats were exposed to clean air (control), DE and DE-SOA in the exposure chamber for 5 h per day (from 10:00 pm to 3:00 am), 5 days a week excluding weekends from gestational day 14 to postnatal day 21 with their pups. At postnatal day 21, the male and female offspring rats were allocated into three different groups as follows: 1) rats exposed to clean filtered air; 2) rats exposed to DE; 3) rats exposed to DE-SOA. Social behaviors were investigated at 10~13-weeks-old rats using a 3-chambered social behavior test, social dominance tube test and marble burying test. Prefrontal cortex was collected to examine neurological and immunological markers, and glutamate concentration, using real-time RT-PCR and ELISA methods. Results: DE-SOA-exposed male and female rats showed poor sociability and social novelty preference, socially dominant behavior and increased repetitive behavior compared with the control rats. The mRNA expression levels of serotonin receptor (5-HT(5B)) and brain-derived neurotrophic factor (BDNF) were down-regulated whereas interleukin 1 b　(IL-b), and heme oxygenase 1 (HO-1) were upregulated in the prefrontal cortex of male and female rats exposed to DE-SOA compared to the control rats. Glutamate concentration was increased significantly in the prefrontal cortex of both male and female rats exposed to DE-SOA.Conclusion: Our results indicate that perinatal exposure to DE-SOA may induce autism-like behavior in rats by modulating neurological and immunological markers in the prefrontal cortex.

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