Gene Expression Profiling Identifies IL-13 Receptor α2 Chain as a Therapeutic Target in Prostate Tumor Cells Overexpressing Adrenomedullin

2006 ◽  
Vol 2006 ◽  
pp. 153
Author(s):  
R. Dhir
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Tumor Cells ◽  
Therapeutic Target ◽  
Expression Profiling ◽  
Prostate Tumor ◽  
Prostate Tumor Cells

scholarly journals Gene expression profiling identifies IL-13 receptor ?2 chain as a therapeutic target in prostate tumor cells overexpressing adrenomedullin

2005 ◽  
Vol 114 (6) ◽  
pp. 870-878 ◽  
Author(s):  
Oscar Gonzalez-Moreno ◽  
Alfonso Calvo ◽  
Bharat H. Joshi ◽  
Ibane Abasolo ◽  
Pamela Leland ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Tumor Cells ◽  
Therapeutic Target ◽  
Expression Profiling ◽  
Prostate Tumor ◽  
Prostate Tumor Cells

scholarly journals Global Gene Expression Profiling of Circulating Tumor Cells

2005 ◽  
Vol 65 (12) ◽  
pp. 4993-4997 ◽  
Author(s):  
Denis A. Smirnov ◽  
Daniel R. Zweitzig ◽  
Bradley W. Foulk ◽  
M. Craig Miller ◽  
Gerald V. Doyle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Expression Profiling ◽  
Global Gene Expression ◽  
Global Gene Expression Profiling

Clonotypic Bone Marrow-Derived Endothelial Progenitor Cells in Multiple Myeloma.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3497-3497
Author(s):  
Marc J. Braunstein ◽  
Daniel R. Carrasco ◽  
David Kahn ◽  
Kumar Sukhdeo ◽  
Alexei Protopopov ◽  
...  
Keyword(s):  
Gene Expression ◽  
Multiple Myeloma ◽  
Bone Marrow ◽  
High Resolution ◽  
Gene Expression Profiling ◽  
Progenitor Cells ◽  
Tumor Cells ◽  
Endothelial Progenitor Cells ◽  
Expression Profiling ◽  
Gains And Losses

Abstract In multiple myeloma (MM), bone marrow-derived endothelial progenitor cells (EPCs) contribute to tumor neoangiogenesis and their levels covary with tumor mass and prognosis. Recent X-chromosome inactivation studies in female patients showed that, similar to tumor cells, EPCs are clonally restricted in MM. Genomic profiling of MM using high-resolution array comparative genomic hybridization (aCGH) has been previously utilized to mine the genome and find clinical correlates in MM patients. In this study, clonotypic aspects of bone marrow-derived EPCs and MM cells were investigated using aCGH and expression profiling analysis. Confluent EPCs were outgrown from bone marrow aspirates by adherence to laminin. EPCs were >98% vWF/CD133/KDR+ and <1% CD38+. The laminin-nonadherent bone marrow fraction enriched for tumor cells was >50% CD38+. For aCGH and for gene expression profiling, genomic DNA and total RNA from EPCs and MM cells were hybridized to human oligonucleotide arrays (Agilent Technologies) and human cDNA microarrays (Affymetrix), respectively. High resolution aCGH with segmentation analysis showed that EPCs and MM cells in one of ten cases share identical patterns of chromosomal gains and losses, while another 5 cases shared multiple focal copy number alterations (CNAs) including gains and losses. The genomes of EPCs and MM cells additionally displayed exclusive CNAs, but these were far fewer in EPCs than in MM cells. In 3 patients, EPCs harbored a common 0.6Mb deletion at 1q21 not shared by MM cells. Pertinent genes in this region that could affect proliferation and tumor suppression include N2N, NBPF10, and TXNIP. Validation studies of aCGH findings by other methods are ongoing. Gene expression profiling showed decreased expression of 1q21 region genes (e.g., calgranulin C and lamin A/C). A genome-wide comparison of patients’ MM cells and EPCs, which is focused on their shared genetic characteristics, will be presented.

PP 83 Gene expression profiling of circulating tumor cells in breast cancer

2011 ◽  
Vol 47 ◽  
pp. S12-S13
Author(s):  
V. Cappelletti ◽  
E. Fina ◽  
P. Miodini ◽  
M. Callari ◽  
V. Musella ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Gene Expression Profiling ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Expression Profiling

scholarly journals Gene expression profiling of single circulating tumor cells in ovarian cancer - Establishment of a multi-marker gene panel

2016 ◽  
Vol 10 (7) ◽  
pp. 1030-1042 ◽  
Author(s):  
Christina Blassl ◽  
Jan Dominik Kuhlmann ◽  
Alessandra Webers ◽  
Pauline Wimberger ◽  
Tanja Fehm ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Gene Expression Profiling ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Expression Profiling ◽  
Marker Gene ◽  
Gene Panel

scholarly journals Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients

2012 ◽  
Vol 14 (5) ◽  
Author(s):  
Antonia Patsialou ◽  
Yarong Wang ◽  
Juan Lin ◽  
Kathleen Whitney ◽  
Sumanta Goswami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Clinical Outcome ◽  
Gene Expression Profiling ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Expression Profiling ◽  
Breast Cancer Patients

scholarly journals MP87-03 TARGETED GENE EXPRESSION PROFILING WITHIN CIRCULATING TUMOR CELLS IN MCRPC

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Udit Singhal ◽  
Yugang Wang ◽  
Zachary Reichert ◽  
Scott Tomlins ◽  
Todd Morgan
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Expression Profiling ◽  
Targeted Gene Expression

Gene expression profiling of single circulating tumor cells in ovarian cancer: Establishment of a multi-marker gene panel.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e17085-e17085
Author(s):  
Tanja N. Fehm ◽  
Christina Blassl ◽  
Jan Dominik Kuhlmann ◽  
Alessandra Webers ◽  
Pauline Wimberger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Gene Expression Profiling ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Expression Profiling ◽  
Marker Gene ◽  
Gene Panel
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