717 META-ANALYSIS OF THE EFFICACY OF THE FENTANYL HCL IONTOPHORETIC TRANSDERMAL SYSTEM (ITS) VERSUS IV PCA IN POST-OPERATIVE ACUTE PAIN MANAGEMENT

2006 ◽  
Vol 10 (S1) ◽  
pp. S187a-S187
Author(s):  
S. Grond ◽  
O. Heisel ◽  
S. Kavanagh ◽  
R. Balshaw ◽  
E. Hunsche
Keyword(s):  
Pain Management ◽  
Acute Pain ◽  
Meta Analysis ◽  
Acute Pain Management ◽  
Iontophoretic Transdermal System

scholarly journals Efficacy and Safety of Intranasal Ketamine for Acute Pain Management in the Emergency Setting: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (17) ◽  
pp. 3978
Author(s):  
Yee Sin Seak ◽  
Junainah Nor ◽  
Tuan Hairulnizam Tuan Kamauzaman ◽  
Ariff Arithra ◽  
Md Asiful Islam
Keyword(s):  
Systematic Review ◽  
Pain Management ◽  
Acute Pain ◽  
Meta Analysis ◽  
Emergency Setting ◽  
Efficacy And Safety ◽  
Acute Pain Management ◽  
Significant Difference ◽  
Mean Differences ◽  
Randomised Controlled

Due to overcrowding, personnel shortages, or problematic intravenous (IV) cannulation, acute pain management is often sub-optimal in emergency departments (EDs). The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of intranasal (IN) ketamine for adult acute pain in the emergency setting. We searched and identified studies up to 21 May 2021 via PubMed, Scopus, Web of Science, Cochrane Database, and Google Scholar. The random-effects model with 95% confidence intervals (CIs) was used to estimate mean differences (MDs) and odds ratios (ORs). The I2 statistic and Cochran’s Q test were used to determine heterogeneity. The protocol was registered in PROSPERO (CRD42020213391). Seven randomised controlled trials were included with a total of 1760 patients. There was no significant difference in pain scores comparing IN ketamine with IV analgesics or placebo at 5 (MD 0.94, p = 0.26), 15 (MD 0.15, p = 0.74), 25 (MD 0.24, p = 0.62), 30 (MD −0.05, p = 0.87), and 60 (MD −0.42, p = 0.53) minutes. There was also no significant difference in the need for rescue analgesics between IN ketamine and IV analgesics (OR 1.66, 95% CI: 0.57−4.86, p = 0.35, I2 = 70%). Only mild adverse effects were observed in patients who received IN ketamine. Our results suggest that IN ketamine is non-inferior to IV analgesics and may have a role in acute pain management among adults in the ED.

A patient-activated iontophoretic transdermal system for acute pain management with fentanyl hydrochloride: Overview and applications

2006 ◽  
Vol 2 (6) ◽  
pp. 314 ◽  
Author(s):  
Kevin T. Bain, PharmD, BCPS, CGP, FASCP
Keyword(s):  
Pain Management ◽  
Postoperative Pain ◽  
Acute Pain ◽  
Medication Administration ◽  
Patient Controlled Analgesia ◽  
Acute Postoperative Pain ◽  
Acute Pain Management ◽  
Free System ◽  
Opioid Administration ◽  
Iontophoretic Transdermal System

Opioid administration by patient-controlled analgesia (PCA) is the standard therapy for acute postoperative pain. Despite its utility in this setting, limitations of this modality do exist. Consequently, noninvasive PCA systems, including an iontophoretic transdermal system (ITS) with fentanyl hydrochloride, are under development to circumvent many of these limitations. This preprogram med, self-contained, compact, needle-free system provides pain con trol superior to that of placebo and comparable to morphine PCA in the first 24 hours after major surgical procedures. The objectives of this article are to describe the method of transdermal iontophoretic medication administration and to review the literature pertaining to the fentanyl ITS.

scholarly journals Lidocaine patch for acute pain management: a meta-analysis of prospective controlled trials

2015 ◽  
Vol 31 (3) ◽  
pp. 575-581 ◽  
Author(s):  
Yaowu Bai ◽  
Timothy Miller ◽  
Mingjuan Tan ◽  
Lawrence Siu-Chun Law ◽  
Tong Joo Gan
Keyword(s):  
Pain Management ◽  
Acute Pain ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Acute Pain Management ◽  
Lidocaine Patch

scholarly journals Intranasal ketamine for acute pain management in children: A systematic review and meta-analysis

2020 ◽  
Vol 38 (9) ◽  
pp. 1860-1866
Author(s):  
Lucas Oliveira J. e Silva ◽  
John Y. Lee ◽  
Fernanda Bellolio ◽  
James L. Homme ◽  
Jana L. Anderson
Keyword(s):  
Systematic Review ◽  
Pain Management ◽  
Acute Pain ◽  
Meta Analysis ◽  
Acute Pain Management

90 Intranasal Ketamine for Acute Pain Management in Children: A Systematic Review and Meta-analysis

2020 ◽  
Vol 76 (4) ◽  
pp. S36
Author(s):  
J.Y. Organick-Lee ◽  
L. Oliveira JE Silva ◽  
F. Bellolio ◽  
J. Homme ◽  
J. Anderson
Keyword(s):  
Systematic Review ◽  
Pain Management ◽  
Acute Pain ◽  
Meta Analysis ◽  
Acute Pain Management
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