scholarly journals UB2 QUANTIFYING THE RELATIONSHIP BETWEEN DISEASE SEVERITY, UTILITY AND HEALTH CARE RESOURCE USE IN CROHN'S DISEASE

2005 ◽  
Vol 8 (6) ◽  
pp. A4
Author(s):  
AR Weston ◽  
PR Gibson ◽  
T Florin ◽  
F Macrae ◽  
G Radford-Smith ◽  
...  
Keyword(s):  
Health Care ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Severity ◽  
Resource Use ◽  
Health Care Resource ◽  
Health Care Resource Use ◽  
The Relationship

scholarly journals Health Care Resource Use and Costs for Crohn’s Disease before and after Infliximab Therapy

2011 ◽  
Vol 25 (9) ◽  
pp. 497-502 ◽  
Author(s):  
Dustin E Loomes ◽  
Christopher Teshima ◽  
Philip Jacobs ◽  
Richard Fedorak
Keyword(s):  
Health Care ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Health Care Costs ◽  
Resource Use ◽  
Health Care Resource ◽  
Infliximab Therapy ◽  
Economic Data ◽  
Before And After ◽  
Care Costs

BACKGROUND: Infliximab therapy in patients with Crohn’s disease decreases resource use; however, the overall impact on health-related expenditures is unclear, especially beyond one year of study.METHODS: A retrospective analysis of economic data one and two years before and after infliximab therapy was performed using patients who served as their own controls. Total health care resource use and direct health care costs were compared for patients with or without fistulae.RESULTS: Patients with one (n=66) and two (n=39) years of economic data before and after infliximab treatment had their resource use and direct health care costs estimated. In the year following initiation of infliximab therapy, there were significant decreases in health care use, reflected in total hospital days (495 to 155 [P<0.05]), inpatient colonoscopies (46 to 24 [P<0.05]), outpatient colonoscopies (58 to 33 [P<0.05]) and major surgeries (10 to 2 [P<0.05]). Direct health care costs of inpatient costs for luminal (−$1,747 [P<0.05]) and fistulizing disease (−$2,530 [P<0.05]), major surgeries (−$1240 [P<0.05]) and outpatient colonoscopies (−$184 [P<0.05]) were also significantly reduced before and after infliximab therapy. Total direct health care costs, including the drug cost of infliximab, increased ($21,416 [P<0.05]). In general, the trends in health care costs analyzed over four consecutive years paralleled the two consecutive-year analysis.CONCLUSIONS: Infliximab therapy in patients with Crohn’s disease resulted in a significant decrease in both resource use and health care costs, but an increase in total direct health care costs once the cost of infliximab was added.

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