Dismal prognosis of patients with post-acute coronary syndrome severe left ventricular dysfunction: how to predict it?

2008 ◽  
Vol 7 ◽  
pp. 101-101
Author(s):  
R BAPTISTA ◽  
E JORGE ◽  
R TEIXEIRA ◽  
C LOURENCO ◽  
N ANTONIO ◽  
...  
2018 ◽  
Vol 5 (3) ◽  
pp. 760
Author(s):  
Sryma P. B. ◽  
Mary Grace N. C. ◽  
Abdul Siyad A. K. ◽  
Ijas Ahamed

Objective of present study to present an atypical manifestation of pheochromocytoma and to illustrate the difficulty in managing an acute coronary syndrome and left ventricular dysfunction during a hypertensive crisis attributable to pheochromocytoma. We present the clinical history, physical findings, lab results and imaging studies of a 62year old man with acute coronary syndrome later found to have an adrenal mass. A 62-year-old man was suspected of having myocardial ischemia on the basis of symptoms of paroxysmal chest discomfort, diaphoresis, ST-segment elevation on an electrocardiogram, and elevated levels of cardiac enzymes. Coronary CT angiography was normal. Echocardiography revealed substantial ballooning of the apical, anterior, and inferior cardiac walls, consistent with catecholamine induced cardiomyopathy. He had a history of labile hypertension, headache, diaphoresis and palpitations of 4 years' duration. A right adrenal mass detected on Magnetic resonance imaging and increased plasma catecholamine levels were consistent with a pheochromocytoma. Treatment with prazosin and labetalol was initiated, and he underwent a right adrenalectomy, which confirmed thepheochromocytoma. Pheochromocytomas must be considered in the setting of acute coronary syndrome especially with presence of labile blood pressure. Inadvertent fibrinolysis can be avoided with proper clinical suspicion and timely coronary imaging.


Inflammation ◽  
2011 ◽  
Vol 35 (1) ◽  
pp. 363-370 ◽  
Author(s):  
Luisa De Gennaro ◽  
Natale Daniele Brunetti ◽  
Deodata Montrone ◽  
Fiorella De Rosa ◽  
Andrea Cuculo ◽  
...  

2007 ◽  
Vol 6 (1) ◽  
pp. 165-165
Author(s):  
M BABARSKIENE ◽  
D LUKSIENE ◽  
B SLAPIKIENE ◽  
J VENCLOVIENE ◽  
I MILVIDATE ◽  
...  

2020 ◽  
Vol 29 (2) ◽  
pp. 65-74
Author(s):  
Christian Richard

Décrit initialement par des auteurs japonais dans les années 1990 le Syndrome de Takotsubo se présente comme un infarctus du myocarde associé à une dysfonction ventriculaire gauche sévère. La coronarographie est en général normale et la dysfonction ventriculaire gauche s’étend au-delà d’un territoire concerné par une seule artère coronaire. Les causes et la physiopathologie du Syndrome de Takotsubo restent à ce jour mal identifiées et comprises. En dépit de la survenue de complications cardio-vasculaires à la phase initiale chez les patients à risque élevé, le pronostic reste en général excellent même si les études les plus récemment publiées suggèrent la possibilité de séquelles et de récurrence. Les critères diagnostiques du Syndrome de Takotsubo ont été récemment publiés par la Société Européenne de Cardiologie afin d’éliminer l’existence d’un syndrome coronarien aigu et d’une myocardite. L’existence de Syndrome de Takotsubo primaire et secondaire a été rapportée et une stratification en risque modéré et élevé proposée. La prescription classique de beta bloquants tant en chronique qu’en aigu lorsqu’elle n’est pas contre indiquée est aujourd’hui remise en question au vu des résultats négatifs d’études prospectives récemment publiées. Des essais contrôlés randomisés et un suivi de cohorte précis sont nécessaires pour définir les modalités de la prise en charge thérapeutique et du suivi. Initially described by Japanese authors in the 1990s Takotsubo Syndrome presents as an acute myocardial infarction associated with severe left ventricular dysfunction. Coronary angiogram is generally within normal limits and left ventricular dysfunction extends beyond the territory concerned by a single coronary artery. The cause and pathogenesis of Takotsubo syndrome remain poorly understood. Despite the onset of complications at the initial phase in some high risk patients the prognosis is usually benign but the most recently published studies suggest the possibility of sequelae and recurrences. Diagnostic criteria for Takotsubo Syndrome have been recently published by the European Society of Cardiology in order to eliminate acute coronary syndrome and myocarditis. Primary and secondary Takotsubo Syndromes were reported and risk stratification was defined. The widely reported indication for beta blockers for the treatment of Takotsubo syndrome even at the initial phase of the disease was recently challenged by the negative results of prospective studies. Randomized controlled trials are needed to provide a stronger evidence base for decision-making.


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