4P-0989 The polymorphism in the 3′ untranslated region of IL-12B and plasma oxidized LDL concentrations in type 2 diabetic patients

2003 ◽  
Vol 4 (2) ◽  
pp. 291
Author(s):  
Y. Ikeda ◽  
S. Tsuzura ◽  
R. Suehiro ◽  
W. Yoshida ◽  
K. Ota ◽  
...  
Keyword(s):  
Untranslated Region ◽  
Oxidized Ldl ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Metformin restores the correlation between serum-oxidized LDL and leptin levels in type 2 diabetic patients

Redox Report ◽  
2011 ◽  
Vol 16 (5) ◽  
pp. 193-200 ◽  
Author(s):  
Manouchehr Nakhjavani ◽  
Afsaneh Morteza ◽  
Firuzeh Asgarani ◽  
Abnoos Mokhtari ◽  
Alireza Esteghamati ◽  
...  
Keyword(s):  
Oxidized Ldl ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Effect of insulin treatment on plasma oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients

2006 ◽  
Vol 32 (6) ◽  
pp. 625-631 ◽  
Author(s):  
F Galland ◽  
L Duvillard ◽  
JM Petit ◽  
L Lagrost ◽  
G Vaillant ◽  
...  
Keyword(s):  
Insulin Treatment ◽  
Ldl Cholesterol ◽  
Oxidized Ldl ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cholesterol Ratio ◽  
Type 2 Diabetic

Association of macroalbuminuria with oxidized LDL and TGF-β in type 2 diabetic patients: a case–control study

2009 ◽  
Vol 42 (2) ◽  
pp. 487-492 ◽  
Author(s):  
Manouchehr Nakhjavani ◽  
Alireza Esteghamati ◽  
Omid Khalilzadeh ◽  
Firouzeh Asgarani ◽  
Nasrin Mansournia ◽  
...  
Keyword(s):  
Case Control Study ◽  
Oxidized Ldl ◽  
Case Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic ◽  
Control Study

scholarly journals Elevated Levels of Plasma IgA Autoantibodies against Oxidized LDL Found in Proliferative Diabetic Retinopathy but Not in Nonproliferative Retinopathy

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Satu Vavuli ◽  
Tuire Salonurmi ◽  
Sirpa Loukovaara ◽  
Antti E. Nissinen ◽  
Markku J. Savolainen ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Oxidized Ldl ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 1 Diabetic Patients ◽  
Type 2 Diabetic

Aims. This study investigated the association of autoantibodies binding to oxidized low-density lipoproteins (oxLDL) in diabetic retinopathy (DR). Methods. Plasma from 229 types 1 and 2 patients with DR including diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) was analysed with ELISA-based assay to determine IgA, IgG, and IgM autoantibody levels binding to oxLDL. The controls were 106 diabetic patients without retinopathy (NoDR) and 139 nondiabetic controls (C). Results. PDR group had significantly higher IgA autoantibody levels than DME or NoDR: mean 94.9 (SD 54.7) for PDR, 75.5 (41.8) for DME (p=0.001), and 76.1 (48.2) for NoDR (p=0.008). There were no differences in IgG, IgM, or IgA that would be specific for DR or for DME. Type 2 diabetic patients had higher levels of IgA autoantibodies than type 1 diabetic patients (86.0 and 65.5, resp., p=0.004) and the highest levels in IgA were found in type 2 diabetic patients with PDR (119.1, p>0.001). Conclusions. IgA autoantibodies were increased in PDR, especially in type 2 diabetes. The high levels of IgA in PDR, and especially in type 2 PDR patients, reflect the inflammatory process and enlighten the role of oxLDL and its autoantibodies in PDR.

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