Institutional audit of geriatric patients treated with pencil beam scanning (PBS) proton beam therapy(PBT) – Toxicities and early outcomes

2021 ◽  
Vol 12 (8) ◽  
pp. S11
Author(s):  
U. Gaikwad ◽  
S. Nangia ◽  
S. Chilukuri ◽  
A. Mathew ◽  
R. Jalali
Keyword(s):  
Proton Beam ◽  
Geriatric Patients ◽  
Proton Beam Therapy ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning

PO-1460 Adaptive re-planning with image guided pencil beam scanning proton beam therapy

2021 ◽  
Vol 161 ◽  
pp. S1197-S1198
Author(s):  
S. Chilukuri ◽  
U. Gaikwad ◽  
S. Nangia ◽  
K. Patro ◽  
R. Thiagarajan ◽  
...  
Keyword(s):  
Proton Beam ◽  
Proton Beam Therapy ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Image Guided ◽  
Pencil Beam Scanning

PO-1419 Toxicity outcomes of hypofractionated pencil beam scanning proton beam therapy for spinal Chordomas

2021 ◽  
Vol 161 ◽  
pp. S1166
Author(s):  
N. Burela ◽  
S. Chilukuri ◽  
S. Nangia ◽  
K. Patro ◽  
N. Mp ◽  
...  
Keyword(s):  
Proton Beam ◽  
Proton Beam Therapy ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning

scholarly journals FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1012
Author(s):  
Shannon Cunningham ◽  
Shelby McCauley ◽  
Kanimozhi Vairamani ◽  
Joseph Speth ◽  
Swati Girdhani ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Proton Beam ◽  
Skin Toxicity ◽  
Tumor Control ◽  
High Dose ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Dose Rates ◽  
Pencil Beam Scanning ◽  
Tgf Β1

Ultra-high dose rate radiation has been reported to produce a more favorable toxicity and tumor control profile compared to conventional dose rates that are used for patient treatment. So far, the so-called FLASH effect has been validated for electron, photon and scattered proton beam, but not yet for proton pencil beam scanning (PBS). Because PBS is the state-of-the-art delivery modality for proton therapy and constitutes a wide and growing installation base, we determined the benefit of FLASH PBS on skin and soft tissue toxicity. Using a pencil beam scanning nozzle and the plateau region of a 250 MeV proton beam, a uniform physical dose of 35 Gy (toxicity study) or 15 Gy (tumor control study) was delivered to the right hind leg of mice at various dose rates: Sham, Conventional (Conv, 1 Gy/s), Flash60 (57 Gy/s) and Flash115 (115 Gy/s). Acute radiation effects were quantified by measurements of plasma and skin levels of TGF-β1 and skin toxicity scoring. Delayed irradiation response was defined by hind leg contracture as a surrogate of irradiation-induced skin and soft tissue toxicity and by plasma levels of 13 different cytokines (CXCL1, CXCL10, Eotaxin, IL1-beta, IL-6, MCP-1, Mip1alpha, TNF-alpha, TNF-beta, VEGF, G-CSF, GM-CSF and TGF- β1). Plasma and skin levels of TGF-β1, skin toxicity and leg contracture were all significantly decreased in FLASH compared to Conv groups of mice. FLASH and Conv PBS had similar efficacy with regards to growth control of MOC1 and MOC2 head and neck cancer cells transplanted into syngeneic, immunocompetent mice. These results demonstrate consistent delivery of FLASH PBS radiation from 1 to 115 Gy/s in a clinical gantry. Radiation response following delivery of 35 Gy indicates potential benefits of FLASH versus conventional PBS that are related to skin and soft tissue toxicity.

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