Use of bone turnover markers in postmenopausal osteoporosis

2017 ◽  
Vol 5 (11) ◽  
pp. 908-923 ◽  
Author(s):  
Richard Eastell ◽  
Pawel Szulc
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Turnover Markers

scholarly journals Serumβ-Catenin Levels Associated with the Ratio of RANKL/OPG in Patients with Postmenopausal Osteoporosis

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Xiao-Juan Xu ◽  
Lin Shen ◽  
Yan-Ping Yang ◽  
Rui Zhu ◽  
Bo Shuai ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Women ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Enzyme Linked Immunosorbent Assay ◽  
Functional Communication ◽  
Mineral Density ◽  
Wnt Pathways ◽  
Turnover Markers

Objective. To demonstrate the role of Wnt/β-catenin canonical pathway in postmenopausal osteoporosis by evaluating serumβ-catenin levels in patients with postmenopausal osteoporosis and analyzing their possible relationship with serum OPG, RANKL, the ratio of RANKL/OPG, sclerostin, and bone turnover markers.Methods. 480 patients with postmenopausal osteoporosis and 170 healthy postmenopausal women were enrolled in the study. Serumβ-catenin, OPG, RANKL, and sclerostin levels were measured by enzyme-linked immunosorbent assay. Bone status was assessed by measuring bone mineral density and bone turnover markers. Estradiol levels were also detected.Results. Serumβ-catenin levels were lower in postmenopausal osteoporotic women compared to nonosteoporotic postmenopausal women (26.26±14.81versus39.33±5.47 pg/mL,P<0.001). Serumβ-catenin was positively correlated with osteoprotegerin (r=0.232,P<0.001) and negatively correlated with the ratio of RANKL/OPG, body mass index, and sclerostin (r=-0.128,P=0.005;r=-0.117,P=0.010;r=-0.400,P<0.001, resp.) in patients with postmenopausal osteoporosis.Conclusion. The results indicate that lower serumβ-catenin and concomitantly higher ratio of RANKL/OPG may be involved in the pathogenesis of postmenopausal osteoporosis. Functional communication between RANKL/RANK/OPG system and Wnt pathways plays an important role in postmenopausal osteoporosis.

Prognostic interest of bone turnover markers in the management of postmenopausal osteoporosis

2012 ◽  
Vol 79 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Florence Chopin ◽  
Emmanuel Biver ◽  
Thomas Funck-Brentano ◽  
Béatrice Bouvard ◽  
Guillaume Coiffier ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Turnover Markers

scholarly journals Response of bone turnover markers to three oral bisphosphonate therapies in postmenopausal osteoporosis: the TRIO study

2015 ◽  
Vol 27 (1) ◽  
pp. 21-31 ◽  
Author(s):  
K. E. Naylor ◽  
R. M. Jacques ◽  
M. Paggiosi ◽  
F. Gossiel ◽  
N. F. A. Peel ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Oral Bisphosphonate ◽  
Turnover Markers

scholarly journals Effect of Monitoring Bone Turnover Markers on Persistence with Risedronate Treatment of Postmenopausal Osteoporosis

2007 ◽  
Vol 92 (4) ◽  
pp. 1296-1304 ◽  
Author(s):  
Pierre D. Delmas ◽  
Bernard Vrijens ◽  
Richard Eastell ◽  
Christian Roux ◽  
Huibert A. P. Pols ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Turnover Markers

Head-to-head comparison of risedronate vs. teriparatide on bone turnover markers in women with postmenopausal osteoporosis: a randomised trial

2008 ◽  
Vol 62 (6) ◽  
pp. 919-924 ◽  
Author(s):  
A. D. Anastasilakis ◽  
D. G. Goulis ◽  
S. A. Polyzos ◽  
S. Gerou ◽  
G. N. Koukoulis ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Randomised Trial ◽  
Turnover Markers

scholarly journals Effects of discontinuing oral bisphosphonate treatments for postmenopausal osteoporosis on bone turnover markers and bone density

2018 ◽  
Vol 29 (6) ◽  
pp. 1407-1417 ◽  
Author(s):  
K. E. Naylor ◽  
M. Bradburn ◽  
M. A. Paggiosi ◽  
F. Gossiel ◽  
N. F. A. Peel ◽  
...  
Keyword(s):  
Bone Density ◽  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Oral Bisphosphonate ◽  
Turnover Markers
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