scholarly journals Use of antiretroviral therapy in households and risk of HIV acquisition in rural KwaZulu-Natal, South Africa, 2004–12: a prospective cohort study

2014 ◽  
Vol 2 (4) ◽  
pp. e209-e215 ◽  
Author(s):  
Alain Vandormael ◽  
Marie-Louise Newell ◽  
Till Bärnighausen ◽  
Frank Tanser
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Antiretroviral Therapy ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Kwazulu Natal ◽  
Hiv Acquisition ◽  
Risk Of Hiv Acquisition

scholarly journals High Incidence of Unplanned Pregnancy after Antiretroviral Therapy Initiation: Findings from a Prospective Cohort Study in South Africa

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e36039 ◽  
Author(s):  
Sheree R. Schwartz ◽  
Helen Rees ◽  
Shruti Mehta ◽  
Willem Daniel Francois Venter ◽  
Taha E. Taha ◽  
...  
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Antiretroviral Therapy ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Unplanned Pregnancy ◽  
Therapy Initiation ◽  
High Incidence

scholarly journals Effect of the Number of Pregnancies on Mortality Risk in HIV-Infected Women: a Prospective Cohort Study in Rural KwaZulu-Natal, South Africa

2018 ◽  
Vol 22 (12) ◽  
pp. 3971-3980
Author(s):  
Hyunsuk Yoo ◽  
Juyeon Lee ◽  
Jae-Joon Yim ◽  
Till Bärnighausen ◽  
Frank Tanser ◽  
...  
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Mortality Risk ◽  
Prospective Cohort ◽  
Kwazulu Natal

scholarly journals Impact of the test and treat policy on delays in antiretroviral therapy initiation among adult HIV positive patients from six clinics in Johannesburg, South Africa: results from a prospective cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. e030228 ◽  
Author(s):  
Dorina Onoya ◽  
Tembeka Sineke ◽  
Cheryl Hendrickson ◽  
Idah Mokhele ◽  
Mhairi Maskew ◽  
...  
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Antiretroviral Therapy ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Hiv Positive ◽  
Adjusted Relative Risk ◽  
Hiv Diagnosis ◽  
Test And Treat ◽  
Art Initiation

ObjectivesTo assess delays to antiretroviral therapy (ART) initiation before and after the Universal Test and Treat (UTT) and the same-day initiation (SDI) of ART policy periods in Johannesburg, South Africa.DesignProspective cohort study.SettingPatients were recruited from six primary health clinics in Johannesburg.ParticipantsOverall, 1029 newly diagnosed HIV positive adults (≥18 years) were consecutively enrolled by referral from the testing counsellor between April and December 2015 (pre-UTT n=146), July and August 2017 (UTT, n=141) and October 2017 and August 2018 (SDI, n=742).Main outcome measuresCox proportional hazards regression was used to assess predictors of 30 days ART initiation. Additionally, predictors of immediate ART initiation were evaluated using Poisson regression.ResultsOverall, 30 days ART proportions were 71.9% overall, 36.9% pre-UTT (44.3% of those eligible), 65.9% under UTT and 79.9% under the SDI policy. The median days to ART initiation declined from 21 pre-UTT (IQR: 15–30) to 8 (IQR: 6–16) under UTT and 5 days (IQR: 0–8) under the SDI policy. However, only 150 (20.2%) of the SDI cohort-initiated ART immediately after HIV diagnosis. Living in a two-adult home (adjusted HR (aHR) 1.2 vs living alone, 95% CI 1.0 to 1.5) increased the likelihood of 30-day ART. Missing baseline cluster of differentiation four (CD4) data decreased the likelihood of 30 days ART by 40% (aHR 0.6 vs CD4 <350 cells/µL, 95% CI 0.5 to 0.7). More women took up immediate ART (adjusted relative risk (aRR) 1.3, 95% CI 1.0 to 1.9). Participants ≥40 years (aRR 0.6 vs 18–24 years, 95% CI 0.4 to 0.9) were less likely to start ART immediately after HIV diagnosis. However, immediate ART rates increased with longer policy implementation time (aRR 0.2 for <3 months vs >10 months, 95% CI 0.1 to 0.4).ConclusionsThe study results highlight a positive move towards earlier ART initiation during the UTT and SDI periods and emphasise a need to increase same-day ART implementation further.

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