scholarly journals Survival time and its predictors in preterm infants in the post-discharge neonatal period: a prospective cohort study in Busoga Region, Uganda

2020 ◽  
Vol 8 ◽  
pp. S6
Author(s):  
Charles Opio ◽  
Richard Malumba ◽  
Joseph Kagaayi ◽  
Olufemi Ajumobi ◽  
Carol Kamya ◽  
...  
Keyword(s):  
Cohort Study ◽  
Survival Time ◽  
Preterm Infants ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Neonatal Period ◽  
Post Discharge

scholarly journals Exposure to any antenatal corticosteroids and outcomes in preterm infants by gestational age: prospective cohort study

BMJ ◽  
2017 ◽  
pp. j1039 ◽  
Author(s):  
Colm P Travers ◽  
Reese H Clark ◽  
Alan R Spitzer ◽  
Abhik Das ◽  
Thomas J Garite ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Prospective Cohort Study ◽  
Gestational Age ◽  
Prospective Cohort ◽  
Antenatal Corticosteroids

A Prospective Cohort Study of Fecal miR-223 and miR-451a as Noninvasive and Specific Biomarkers for Diagnosis of Necrotizing Enterocolitis in Preterm Infants

Neonatology ◽  
2020 ◽  
pp. 1-7
Author(s):  
Pak Cheung Ng ◽  
Kathy Yuen Yee Chan ◽  
Hugh Simon Lam ◽  
Raymond Pui On Wong ◽  
Terence Ping Yuen Ma ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Clinical Presentation ◽  
Fecal Calprotectin ◽  
Controlled Study ◽  
Clinical Value ◽  
Predictive Values

<b><i>Objective:</i></b> The objective of this study is to evaluate the usefulness of fecal microRNA (miR)-223 and miR-451a, as novel noninvasive biomarkers for early diagnosis of necrotizing enterocolitis (NEC) in preterm infants. <b><i>Methods:</i></b> Among the top-listed target miRNAs in our previous differential microarray analysis, miR-223 and miR-451a were quantified in a pilot validation case-controlled study (NEC vs. non-NEC/nonsepsis infants; <i>n</i> = 6 in each group). A definitive prospective cohort study (<i>n</i> = 218) further assessed their clinical usefulness as noninvasive and specific diagnostic biomarkers. Fecal calprotectin was quantified in parallel for comparison. <b><i>Results:</i></b> Of 43 proven NEC cases in the cohort study, 24 (55.8%) had fecal samples recovered within the first 3 days of clinical presentation. Fecal miRNA-223 (10.5 fold), miR-451a (4.5 fold), and calprotectin (2.1 fold) concentrations were significant higher in NEC compared with the non-NEC group (<i>p</i> &#x3c; 0.009). Accepting a minimum sensitivity of 0.75, the positive predictive values (PPVs) ranged between 0.19 and 0.20. Combining fecal biomarkers and CRP (Day 1) could marginally increase the PPVs (0.31–0.34) but adversely lowered the sensitivity (0.54–0.63). <b><i>Conclusions:</i></b> Although fecal miRNA biomarkers and calprotectin concentrations were significantly higher in the NEC group, the considerable overlapping of concentrations between groups and low recovery of stool specimens within 72 h of clinical presentation rendered fecal noninvasive tests of limited clinical value in guiding diagnosis of NEC during the acute phase. A further study is underway to evaluate their roles in surveillance for predicting high-risk premature infants developing NEC.

scholarly journals Clinical features and outcomes of discharged coronavirus disease 2019 patients: a prospective cohort study

QJM ◽  
2020 ◽  
Vol 113 (9) ◽  
pp. 657-665 ◽  
Author(s):  
X Wang ◽  
H Xu ◽  
H Jiang ◽  
L Wang ◽  
C Lu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Outcomes ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Close Contact ◽  
Post Discharge ◽  
Global Pandemic ◽  
Discharged Patients ◽  
Suspected Recurrence

Summary Background Coronavirus disease 2019 (COVID-19) is a global pandemic but the follow-up data of discharged patients was barely described. Aim To investigate clinical outcomes, distribution of quarantine locations and the infection status of the contacts of COVID-19 patients after discharge. Design A prospective cohort study. Methods Demographics, baseline characteristics of 131 COVID-19 patients discharged from 3 February 2020 to 21 February 2020 in Wuhan, China were collected and analyzed by reviewing the medical records retrospectively. Post-hospitalization data related to clinical outcomes, quarantine locations and close contact history were obtained by following up the patients every week up to 4 weeks. Results Fifty-three (40.05%) patients on discharge had cough (29.01%), fatigue (7.63%), expectoration (6.11%), chest tightness (6.11%), dyspnea (3.82%), chest pain (3.05%) and palpitation (1.53%). These symptoms constantly declined in 4 weeks post-discharge. Transient fever recurred in 11 (8.4%) patients. Among the discharged patients, 78 (59.5%) underwent chest CT and 2 (1.53%) showed deterioration. A total of 94 (71.8%) patients received SARS-CoV-2 retest and 8 (6.10%) reported positive. Seven (2.29%) patients were readmitted because of fever or positive SARS-CoV-2 retest. After discharge, 121 (92.37%) and 4 (3.05%) patients were self-quarantined at home or community spots, respectively, after a close contact with 167 persons in total who were free of COVID-19 at the endpoint of study. Conclusion The majority of COVID-19 patients after discharge were in the course of recovery. Readmission was required in rare cases due to suspected recurrence of COVID-19. Although no contacted infection observed, appropriate self-quarantine and regular re-examination are necessary, particularly for those who have recurred symptoms.

scholarly journals Homocysteine levels in preterm infants: is there an association with intraventricular hemorrhage? a prospective cohort study

2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Wendy J Sturtz ◽  
Kathleen H Leef ◽  
Amy B Mackley ◽  
Shailja Sharma ◽  
Teodoro Bottiglieri ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Infants ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Intraventricular Hemorrhage

scholarly journals Pre-diagnosis consumption of preserved vegetables and prognosis of invasive oesophageal squamous cell carcinoma: a prospective cohort study in one high-risk area in China

2018 ◽  
Vol 46 (10) ◽  
pp. 4306-4314 ◽  
Author(s):  
Feng Shi ◽  
Fengcai Yan ◽  
Mulan Jin ◽  
Hong Chang ◽  
Quan Zhou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cohort Study ◽  
Cell Carcinoma ◽  
Survival Time ◽  
Median Survival ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Median Survival Time ◽  
Vegetable Consumption ◽  
Oesophageal Squamous Cell Carcinoma

Objective To investigate the prognostic effect of pre-diagnosis preserved vegetable consumption on oesophageal squamous cell carcinoma (ESCC) in Yanting County, China. Methods This prospective cohort study enrolled consecutive patients with ESCC. The pre-diagnosis diet consumption data were collected using a food frequency questionnaire at baseline. Preserved vegetable consumption was categorized into two groups: < 1/week and ≥1/week. Kaplan–Meier survival curve analysis with a log-rank test and a Cox proportional hazard regression model analysis were undertaken to compare the two consumption groups. Results The study enrolled 185 patients (121 males and 64 females) with ESCC. Patients consuming preserved vegetables ≥1/week had a median survival time of 41 months, but patients consuming preserved vegetables <1/week did not achieve a median survival time. The adjusted hazard ratio (HR) for an intake of ≥1/week was 1.58 (95% confidence interval [CI] 1.01, 2.47). Among ‘ever smokers’, the HR increased to 2.04 (95% CI 1.10, 3.77) and among ‘ever alcohol drinkers’, the HR increased to 2.50 (95% CI 1.33, 4.73). Among ‘never smokers’ or ‘never alcohol drinkers’, no significant association was observed. Conclusion A high consumption of preserved vegetables was associated with a poorer prognosis among patients with ESCC.

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