Imaging Mechanisms of Drug Resistance in Experimental Models of Epilepsy

2019 ◽  
pp. 148-156
Author(s):  
Jens P. Bankstahl ◽  
Marion Bankstahl
Keyword(s):  
Drug Resistance ◽  
Experimental Models ◽  
Imaging Mechanisms ◽  
Models Of Epilepsy

Intranasal pitavastatin attenuates seizures in different experimental models of epilepsy in mice

2017 ◽  
Vol 75 ◽  
pp. 56-59 ◽  
Author(s):  
Muhammad Usama Ashhar ◽  
Mohd. Zubair Ahmad ◽  
Vikas Jain ◽  
Nidhi B. Agarwal ◽  
Farhan J. Ahmad ◽  
...  
Keyword(s):  
Experimental Models ◽  
Models Of Epilepsy

scholarly journals Research and development of 2-ethyl-6-methyl-3-oxypyridine succinate nano-form for the treatment of epilepsy

2019 ◽  
Vol 10 (4) ◽  
pp. 26-38
Author(s):  
G. G. Avakyan ◽  
T. A. Voronina ◽  
L. N. Nerobkova ◽  
G. N. Avakyan
Keyword(s):  
Status Epilepticus ◽  
Research And Development ◽  
Active Ingredient ◽  
Active Substance ◽  
Drug Transport ◽  
Experimental Models ◽  
Polymer Nanoparticles ◽  
Biologically Active ◽  
Epileptic Focus ◽  
Models Of Epilepsy

The aimis to develop an antiepileptic drug based on polymer nanoparticles with 2-ethyl-6-methyl-3-oxypyridine succinate to facilitate the drug transport through the blood-brain barrier.Materials and methods.The nano-drug was created using the biologically active substance 2-ethyl-6-methyl-3-hydroxypyridine succinate and polybutyl cyanoacrylate (PBCA) nanoparticles. The advantages of this nano-form over the active ingredient of the same drug were studied using experimental models: the maximum electroshock test (MES), the antagonism test with corazol, models with a cobaltinduced epileptic focus and secondary generalized convulsions, and models of status epilepticus.Results.The antiseizure effects of the nanoform on the experimental models of epilepsy are identified.Conclusion.The nano-drug reduces the number of secondary generalized clonic-tonic seizures by 7.8 times; it also reduces 10-fold the animal mortality and diminishes the seizure manifestations that occur in the interictal period of the epileptic status.

scholarly journals Gaseous neurotransmitter nitric oxide: Its role in experimental models of epilepsy

2012 ◽  
Vol 64 (3) ◽  
pp. 1207-1216 ◽  
Author(s):  
D. Hrncic ◽  
Aleksandra Rasic-Markovic ◽  
Jelica Bjekic-Macut ◽  
Veselinka Susic ◽  
D. Mladenovic ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Experimental Studies ◽  
Experimental Models ◽  
Initiation And Propagation ◽  
Organ Systems ◽  
The Central Nervous System ◽  
Animal Models Of Epilepsy ◽  
Almost All ◽  
Gaseous Neurotransmitter ◽  
Models Of Epilepsy

Epilepsy is one of the leading neurological disorders and affects 1-2% of the world?s population. Generally, it is a result of an imbalance between excitatory and inhibitory phenomena in the central nervous system (CNS), but the mechanisms of its initiation and propagation still require further investigations. Experimental models represent one of the most powerful tools to better understand the mechanisms of epileptogenesis. Nitric oxide (NO) is gaseous molecule with pleiotropic physiological and pathological effects in almost all organ systems and intriguing biological relevance, especially in the CNS where it acts as a gaseous neurotransmitter. The role of NO in the generation of epilepsy is highly contradictory, since there is evidence of its anticonvulsive, as well as proconvulsive properties. Therefore, we will discuss in this review the involvement of NO-mediated signaling pathways in the mechanisms of epileptogenesis, taking into account the findings revealed in experimental studies on animal models of epilepsy.

scholarly journals Editorial: Experimental Models of Epilepsy and Related Comorbidities

2019 ◽  
Vol 10 ◽  
Author(s):  
Ayanabha Chakraborti ◽  
Mohd. Farooq Shaikh ◽  
Annamaria Vezzani ◽  
Jafri Malin Abdullah
Keyword(s):  
Experimental Models ◽  
Models Of Epilepsy

Zinc, magnesium and copper profiles in three experimental models of epilepsy

2002 ◽  
Vol 956 (1) ◽  
pp. 166-172 ◽  
Author(s):  
M.C Doretto ◽  
S Simões ◽  
A.M.R Paiva ◽  
E Osório-Neto
Keyword(s):  
Experimental Models ◽  
Models Of Epilepsy

Central actions of valproic acid in man and in experimental models of epilepsy

Life Sciences ◽  
1981 ◽  
Vol 29 (25) ◽  
pp. 2561-2574 ◽  
Author(s):  
E.J. Hammond ◽  
B.J. Wilder ◽  
J. Bruni
Keyword(s):  
Valproic Acid ◽  
Experimental Models ◽  
Central Actions ◽  
Models Of Epilepsy

Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice

2011 ◽  
Vol 27 (2) ◽  
pp. 169-172 ◽  
Author(s):  
Nidhi Bharal Agarwal ◽  
Seema Jain ◽  
Dheeraj Nagpal ◽  
Nitin Kumar Agarwal ◽  
Pramod K. Mediratta ◽  
...  
Keyword(s):  
Experimental Models ◽  
Liposomal Formulation ◽  
Models Of Epilepsy
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