Cell transplantation therapy for Parkinson's disease

Background: Dementia is a cognitive degenerative disease generally associated with Alzheimer disease, but victims with Parkinson’s disease also develops dementia at the latter stage. Dementia associates with irreversible loss of memory, and no medicinal cure is yet available. We here put some light on possible cell therapy for dementia. Aim: Neural stem cells are multipotent cells which are capable of self-replication and differentiation into neurons, astrocytes or oligodendrocytes in the central nervous system. They produce Dopamine, neural factors, and therefore, one can expect that NSC transplantation can ultimately provide a better therapeutic approach in the treatment of dementia as well as Parkinson’s disease (PD). Methods: We discussed the merits and demerits of using hNSCs cells over other possible candidate cells. Results: As we found that hNSCs can secrete Dopamine as well as some neurotropic factors, like Brain-Derived Neurotropic Factor (BDNF) and Glial cell-Derived Neurotropic Factors (GDNF) which can support the proliferation of hNSCS and its Dopamine production ability, hNSCs can supply dopamine and also can stop α-synuclein aggregation. Conclusion: hNSCs, therefore, could be a better cell regiment for cell transplantation therapy for dementia as well as PD.

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Knock-Out and Transgenic Strategies to Improve Neural Transplantation Therapy for Parkinson's Disease

10.21236/ada396461 ◽

2001 ◽

Author(s):

Ole Isacson

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Neural Transplantation ◽

Knock Out ◽

Transplantation Therapy

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Neural stem cells: involvement in adult neurogenesis and CNS repair

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.2008.2264 ◽

2008 ◽

Vol 363 (1500) ◽

pp. 2111-2122 ◽

Cited By ~ 71

Author(s):

Hideyuki Okano ◽

Kazunobu Sawamoto

Keyword(s):

Stem Cells ◽

Neural Stem Cells ◽

Cell Transplantation ◽

Adult Neurogenesis ◽

Embryonic Stem ◽

Adult Brain ◽

Therapeutic Interventions ◽

Cell Transplantation Therapy ◽

Transplantation Therapy

Recent advances in stem cell research, including the selective expansion of neural stem cells (NSCs) in vitro , the induction of particular neural cells from embryonic stem cells in vitro , the identification of NSCs or NSC-like cells in the adult brain and the detection of neurogenesis in the adult brain (adult neurogenesis), have laid the groundwork for the development of novel therapies aimed at inducing regeneration in the damaged central nervous system (CNS). There are two major strategies for inducing regeneration in the damaged CNS: (i) activation of the endogenous regenerative capacity and (ii) cell transplantation therapy. In this review, we summarize the recent findings from our group and others on NSCs, with respect to their role in insult-induced neurogenesis (activation of adult NSCs, proliferation of transit-amplifying cells, migration of neuroblasts and survival and maturation of the newborn neurons), and implications for therapeutic interventions, together with tactics for using cell transplantation therapy to treat the damaged CNS.

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