scholarly journals P.017 Nutritional deficiency: A mysterious case of psychosis and seizures

2021 ◽  
Vol 48 (s3) ◽  
pp. S24-S24
Author(s):  
L Bashardost ◽  
M Arevalo-Astrada ◽  
ME Jenkins
Keyword(s):  
Vitamin D ◽  
Clinical Symptoms ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
High Dose ◽  
Membrane Excitability ◽  
Neuroprotective Effects ◽  
Serum Vitamin D ◽  
History Of ◽  
The Central Nervous System

Background: As a neuroactive steroid, vitamin D is essential for optimal neuronal functioning1. Its immunomodulatory and neuroprotective effects aid in reduction of proconvulsant cytokines, membrane excitability and seizure prevention2-3. Deficiency plays an important role in neurological and psychiatric illnesses, though clinical manifestation with seizures and psychosis have not been described. Methods: A 61-year-old female presented with 3-day history of confusion, insomnia and new onset seizure. She was noted to have poor dentition, deformed nail bed and multiple ecchymosis. Neurologically, there were brisk reflexes with some spread. She worsened with frequent seizures and psychosis. Results: Laboratory investigation showed serum Vitamin D level of 19nmol/L, hemoglobin of 70g/L. MRI head revealed T2 hyperintensities in bilateral anterolateral temporal lobes and EEG consistent with bitemporal lobe epilepsy. Autoimmune and infectious work up were negative. Treatment with antipsychotics, several antiepileptics, high dose Vitamin-D and iron supplements were initiated. Initially, she remained unresponsive to neuro/psych medications. Improvement in clinical symptoms was noticed in 4th week of admission, with complete resolution of MRI, EEG findings. Conclusions: Evidence surrounding hypovitaminosis D and risk on the central nervous system continues to grow. This case highlights the significance of vitamin-D on brain processes and its neurological manifestations in state of deficiency. 1. Kalueff.A.,2006. 2. Garcion. E, 2003. 3. Eyles, D., 2013.

Association between vitamin D status and metabolic syndrome in a longitudinal study of Iranian adults

2019 ◽  
Author(s):  
Hossein Khosravi-Boroujeni ◽  
Nizal Sarrafzadegan ◽  
Masoumeh Sadeghi ◽  
Hamidreza Roohafza ◽  
Shu-Kay Ng ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Activity Levels ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Potential Association ◽  
Longitudinal Association ◽  
History Of

Abstract Background In recent years, hypovitaminosis D has been linked to many chronic diseases, including metabolic syndrome (MetS). However, there are considerable discrepancies in the study findings. Therefore, the present study investigated the association between vitamin D status and MetS in a cohort of Iranian adults followed from 2001 to 2013. Method This study was designed using the data from Isfahan cohort study which is an ongoing cohort of Iranian adults. For this study, 170 cases with MetS were selected from those who were free of MetS in 2001 but developed the condition in 2013. Controls (n=200) were selected from those who were free of MetS throughout the study period. Various biochemical parameters, including serum vitamin D concentrations, and socio-demographic information were assessed in 2001, 2007 and 2013. Generalized Estimating Equations was used to analyse the longitudinal association between vitamin D status and MetS. Results The subjects with MetS had higher levels of serum vitamin D [25(OH)D], total cholesterol, triglyceride, body mass index, waist circumference, systolic and diastolic blood pressure than that in the control subjects in 2001, while they had lower physical activity levels. A family history of hyperlipidemia was also more prevalent in the subjects with MetS. This study did not find any association between MetS and serum vitamin D status after controlling for potential confounders. Conclusion In spite of the high prevalence of vitamin D deficiency and MetS among studied population, this study failed to show any association between vitamin D status and MetS and/or its components. Randomized controlled trials are warranted to investigate the potential association more meticulously.

Association of Vitamin D Deficiency in Newly Diagnosed Pulmonary Tuberculosis

2021 ◽  
Vol 15 (10) ◽  
pp. 2572-2573
Author(s):  
Khalil Ullah ◽  
Sajid Ur Rehman ◽  
Ramsha Nadeem ◽  
Muhammad Abubakar ◽  
Qasim Raza
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Sampling Technique ◽  
Hypovitaminosis D ◽  
Control Group ◽  
Sputum Smear ◽  
Study Group ◽  
Serum Vitamin D

Aim: Relationship between Vitamin D deficiency and pulmonary tuberculosis. Methodology: Study duration: November 2020 to April 2021 Sampling technique: A case-control study Setting: Hayatabad Medical Complex, Peshawar It included 30 adult newly identified sputum-quality pulmonary tuberculosis patients and 30 age and sex matched healthy cases as controls. All cases had undergone a thorough medical examination and repeated laboratory tests, including vitamin D, calcium, and sputum for AFB and X-ray chest. Results: Majority were males (88%). In the Study group, BMI decreased significantly i.e. 19.0 vs 23.5. Serum vitamin D concentrations were significantly lower in the tuberculosis group i.e. 17.9ng/dl than in the control group 24.8ng/dl. Mean of serum albumin in the control group was 3.9 ng/dl whereas 2.9 ng/dl in the study group. Conclusion: Hypovitaminosis D was associated with more severe medical symptoms, increased sputum smear positivity and large lesions on chest radiographs in patients with pulmonary tuberculosis. Keywords: Vitamin D, Pulmonary Tuberculosis, Sputum

Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome

2018 ◽  
Vol 38 (4) ◽  
pp. 327-333 ◽  
Author(s):  
Amir Abbasnezhad ◽  
Reza Amani ◽  
Amin Hasanvand ◽  
Esmaeil Yousefi Rad ◽  
Meysam Alipour ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vitamin D ◽  
Irritable Bowel Syndrome ◽  
Clinical Symptoms ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Irritable Bowel

scholarly journals Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3176
Author(s):  
Sharon M. Anderson ◽  
Andrea R. Thurman ◽  
Neelima Chandra ◽  
Suzanne S. Jackson ◽  
Susana Asin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Reproductive Tract ◽  
Serum Vitamin ◽  
Female Reproductive Tract ◽  
High Dose ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Hiv 1

While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels <62.5 nmol/L. Participants were randomized into either weekly or daily high-dose oral vitamin D supplementation groups. In addition to serum vitamin D levels, genital mucosal endpoints, including soluble mediators, immune cell populations, gene expression, and ex vivo HIV-1 infection, were assessed. While systemic vitamin D levels showed a significant increase following supplementation, these changes translated into modest effects on the cervicovaginal factors studied. Paradoxically, post-supplementation vitamin D levels were decreased in cervicovaginal fluids. Given the strong correlation between vitamin D status and HIV-1 infection and the widespread nature of vitamin D deficiency, further understanding of the role of vitamin D immunoregulation in the female reproductive tract is important.

scholarly journals Serum vitamin D status and biochemical parameters of asthmatic children in Sokoto Metropolis, North-western Nigeria

2019 ◽  
Vol 11 (2) ◽  
pp. 64-70
Author(s):  
Mohammed Haruna Yeldu ◽  
Mohammed Danjuma ◽  
Mainasara Abdullahi Sulaiman ◽  
Jiya Nma Muhammad ◽  
Garba Balkisu Illah ◽  
...  
Keyword(s):  
Vitamin D ◽  
Biochemical Parameters ◽  
Immunoglobulin E ◽  
Airflow Obstruction ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Asthma Severity ◽  
Vitamin D Status ◽  
Asthmatic Children ◽  
Serum Vitamin D

Background: Asthma is a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms. It is characterized by the occurrence of bronchial hyper responsiveness, airflow obstruction and an underlying inflammation. Several studies have proposed the association of vitamin D with increased incidence of asthma symptoms. Aims and Objectives: This study aimed at determining the serum vitamin D status and biochemical parameters among asthmatic children in Sokoto-Nigeria. Materials and Methods: The study population consisted of 120 subjects including 80 asthmatic children and 40 age-and sex-matched apparently healthy controls from two tertiary Hospitals in Sokoto Metropolis. Serum vitamin D, calcium, parathyroid hormone (PTH), immunoglobulin E (IgE) and magnesium were measured using standard techniques. Results: Mean serum vitamin D and magnesium were significantly (p ˂ 0.05) lower, while serum PTH and IgE were significantly higher (p˂0.001) in asthmatic children than in controls. Vitamin D insufficiency was found to be prevalent among the asthmatic children. There was no significant relationship between the low level of vitamin D and asthma severity. Conclusion: This study observed that, hypovitaminosis D and hypomagnesaemia occurred among asthmatic children, and asthma was more prone in the younger children than in their older counterpart. It is recommended that in order to avoid or limit the rate of children having asthmatic episodes, vitamin D and magnesium supplements should be used in the management of asthmatic children.

scholarly journals Association between vitamin D concentrations and knee pain in patients with osteoarthritis

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4670 ◽  
Author(s):  
Murat Cakar ◽  
Semih Ayanoglu ◽  
Haluk Cabuk ◽  
Metin Seyran ◽  
Suleyman Semih Dedeoglu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Knee Pain ◽  
Clinical Symptoms ◽  
Serum Vitamin ◽  
Womac Score ◽  
Mean Values ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Knee Oa ◽  
Grade 3

Objectives Osteoarthritis (OA) and vitamin D deficiency are common health conditions in older people. Whether vitamin D concentration is associated with knee OA is controversial. In this study, we aimed to determine the association between serum concentrations of vitamin D and osteoarthritic knee pain. Subjects and Methods Vitamin D concentrations were measured with the 25 hydroxyvitamin D test in patients presenting with clinical symptoms of primary knee osteoarthritis. Osteoarthritis was graded on the Kellgren-Lawrence grading scale from anteroposterior and lateral radiographs. Height, weight, and body mass index (BMI) were recorded. Patients completed a 10-cm visual analogue scale (VAS) for indicating pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Vitamin D concentration was defined as severely deficient (<10 ng/mL), insufficient (10 to 19 ng/mL), or normal (20 to 50 ng/mL). Results Of 149 patients (133 women), the mean age was 63.6 years. Mean vitamin D concentration was 11.53 ng/mL, and 90% patients were vitamin D deficient. Mean WOMAC score was 57.2, and VAS pain score was 7.5. Kellgren-Lawrence grade was 2 for 10 patients, grade 3 for 61, and grade 4 for 88. Mean BMI was 33.4. Mean values of VAS, WOMAC, and BMI did not differ by vitamin D status. Conclusion Serum vitamin D concentration is not associated with knee pain in patients with osteoarthritis.

scholarly journals Association between Vitamin D Concentrations and Knee Pain in Patients with Osteoarthritis

2017 ◽  
Vol 5 (2_suppl2) ◽  
pp. 2325967117S0008
Author(s):  
Murat Çakar ◽  
Semih Ayanoğlu ◽  
Haluk Çabuk ◽  
Metin Seyran ◽  
Süleyman Semih Dedeoğlu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Knee Pain ◽  
Clinical Symptoms ◽  
Serum Vitamin ◽  
Womac Score ◽  
Mean Values ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Knee Oa ◽  
Grade 3

Objectives: Osteoarthritis (OA) and vitamin D deficiency are common health conditions in older people. Whether vitamin D concentration is associated with knee OA is controversial. In this study, we aimed to determine the association between serum concentrations of vitamin D and osteoarthritic knee pain. Subjects and Methods: Vitamin D concentrations were measured with the 25 hydroxyvitamin D test in patients presenting with clinical symptoms of primary knee osteoarthritis. Osteoarthritis was graded on the Kellgren-Lawrence grading scale from anteroposterior and lateral radiographs. Height, weight, and body mass index (BMI) were recorded. Patients completed a 10-cm visual analogue scale (VAS) for indicating pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Vitamin D concentration was defined as severely deficient (<10 ng/mL), insufficient (10 to 19 ng/mL), or normal (20 to 50ng/mL). Results: Of 149 patients (133 women) the mean age was 63.6 years. Mean vitamin D concentration was 11.53 ng/mL, and 90% patients were Vitamin D deficient. Mean WOMAC score was 57.2, and VAS pain score was 7.5. Kellgren-Lawrence grade was 2 for 10 patients grade 3 for 61, and grade 4 for 88. Mean BMI was 33.4. Mean values of VAS, WOMAC, and BMI did not differ by vitamin D status. Conclusion: Serum vitamin D concentration is not associated with knee pain in patients with osteoarthritis.

scholarly journals Serum vitamin D content in children with SARS-CoV-2 infection

2021 ◽  
Vol 6 ◽  
pp. 79-82
Author(s):  
V.N. Peregoedova ◽  
◽  
I.K. Bogomolova ◽  
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Clinical Symptoms ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Control Group ◽  
Immunochemical Method ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

Aim of study. To study the total level of 25-hydroxyvitamin D in children with SARS-CoV-2 infection (COVID-19). Material and мethods. A total of 82 children aged 0-17 diagnosed with SARS-CoV-2 infection were enrolled. Depending on the severity of clinical symptoms, all children were divided into three groups according to the COVID-19 severity: asymptomatic, mild and moderate. The serum level of vitamin D in all patients was tested via the immunochemical method. Results. It was found that children with SARS-CoV-2 infection had lower serum level of vitamin D (29.92 [22.22; 28.07] ng/ml) as compared with the control group (36.43 [32.05; 44.08] ng/ml; p<0.001). A total of 90% of the children with SARS-CoV-2 infection were diagnosed with insufficiency or deficiency of vitamin D (<30 ng/ml). Only 10 % of the patients had normal levels of vitamin D. The insufficiency of vitamin D was found more often amongst children aged 0-11 and deficiency of total 25-hydroxyvitamin D was more common for children aged 12-17. The difference in serum levels of vitamin D depending on the severity of SARS-CoV-2 infection was not found. Male children with SARS-CoV-2 infection showed lower levels of vitamin D (p=0.013). Conclusion. A total of 90 % of the children with SARS-CoV-2 infection had insufficiency or deficiency of vitamin D regardless of the severity of clinical symptoms.

scholarly journals Vitamin D Intoxication in An Elderly: A Case Report

2019 ◽  
Vol 3 (4) ◽  
pp. 147-149
Author(s):  
Sahil Singh ◽  
Prernika Mittal ◽  
Ajay Sharma
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
High Serum ◽  
Intravenous Fluids ◽  
Serum Vitamin D ◽  
Replacement Surgery ◽  
Vitamin D Intoxication ◽  
History Of ◽  
Very High

Vitamin D is a very common prescribed drug for numerous indications. Due to scarce knowledge and poor awareness of the various formulations, preparations and dosages of Vitamin D, there are many chances of prescription errors, medication errors, product use issue and undesirable adverse drug reactions. We hereby detail case of 70-year-old ex-army gentleman reported to us with a history of lethargy, confusion, reduced appetite and gait imbalance since few days with a history of knee replacement surgery 2 years back. Medical history was not of much relevance before it was revealed that he was getting cholecalciferol injection with a strength of 600000 IU once a week for few months. He was detected to have very high serum vitamin D level and hypercalcemia. He was started on intravenous fluids, diuretics and glucocorticoids. In a few days, after effective treatment, the patient was discharged in a recovering stage and advised to stop intake calcium and vitamin D in any form. At his last follow up, after a few months of discharge, he had totally recovered.

scholarly journals Status of Vitamin D among Patients Visiting a Tertiary Care Centre in Rupandehi, Nepal

2021 ◽  
Vol 9 (4) ◽  
pp. 256-260
Author(s):  
Tirtha Narayan Shah ◽  
Amar Kumar Sinha ◽  
Krishna Kumar Jha ◽  
Ram Jiban Prasad
Keyword(s):  
Vitamin D ◽  
Tertiary Care ◽  
Age Groups ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Target Population ◽  
Tertiary Care Centre ◽  
Medical College ◽  
Serum Vitamin D ◽  
High Level

Serum vitamin D is one of the fat-soluble vitamin which has the role in maintenance of calcium and phosphorus levels  and ultimately proper bone health and various physiological processes.  Although many studies prevail hypovitaminosis D, we focused to find out the pattern of  elevated or decreased  serum vitamin D level as its deficiency and surplus have adverse effects to our health.. For this, a retrospective study was done from the records present in a hospital laboratory of Devdaha Medical College and Research Institute (DMCRI), Rupandehi, Nepal from January 2018 to December 2020 where 201 participants with 70.1% male and 29.9% female with different age groups were present. From total participants, 14.9% had deficient, 42.8% had insufficient, 35.3% had sufficient and 7%  had high level of serum vitamin D. Male had 2.9% deficient and 14,9% insufficient vitamin D whereas female had 11.9% deficient, 27.8% insufficient and 7.0% surplus vitamin D. The greater prevalence of hypovitaminosis D in the females than the males could be overcome by the necessary strategies in the form of further studies and judicious supplementation vitamin D in the target population by monitoring the level of serum vitamin D. Int. J. Appl. Sci. Biotechnol. Vol 9(4): 256-260.

Sign in / Sign up

Export Citation Format

Share Document