Coffee and Tea Consumption and the Risk of Glioma: A Systematic Review and Dose-Response Meta-Analysis

2021 ◽  
pp. 1-31
Author(s):  
Raymond Pranata ◽  
Andrea Feraldho ◽  
Michael Anthonius Lim ◽  
Joshua Henrina ◽  
Rachel Vania ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dose Response ◽  
Lower Risk ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Case Control ◽  
Tea Consumption ◽  
Case Control Studies ◽  
Relative Risks ◽  
Apparent Association

Abstract In this systematic review and dose-response meta-analysis, we aim to assess whether coffee and tea consumption is related to the risk of glioma. We performed a systematic literature search using PubMed, Embase, Scopus, and the EuropePMC up until 1st October 2020. Exposures in this study were coffee and tea consumption. The main outcome of this study was the incidence of glioma. This study compares the association between the exposure of coffee and tea with the incidence of glioma, the results are reported in Relative Risks (RRs). There are 12 unique studies comprising of 1,960,731 participants with 2,987 glioma cases. Higher coffee consumption was associated with a statistically non-significant trend towards lower risk of glioma (RR 0.77 [0.55, 1.03], p=0.11; I2: 75.27%). Meta-regression showed that the association between coffee and glioma was reduced by smoking (p=0.029). Higher tea consumption was associated with the lower risk of glioma (RR 0.84 [0.71, 0.98], p=0.030; I2: 16.42%). Sensitivity analysis by removal of case-control studies showed that higher coffee consumption (RR 0.85 [0.72, 1.00], p=0.046; I2: 0%) and higher tea consumption (RR 0.81 [0.70, 0.93], p=0.004; I2: 0%, Pnon-linearity=0.140) were associated with lower risk of glioma. Dose-response meta-analysis showed that every 1 cup of coffee per day decreases the risk of glioma by 3% (RR 0.97 [0.94, 0.99], p=0.016, Pnon-linearity=0.054) and every 1 cup of tea per day decreases the risk of glioma by 3% (RR 0.97 [0.94, 1.00], p=0.048). This meta-analysis showed apparent association between coffee and tea intake and risk of glioma.

scholarly journals Mushroom Consumption Is Associated with Low Risk of Cancer: A Systematic Review and Meta-Analysis of Observation Studies

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 307-307 ◽  
Author(s):  
Djibril Ba ◽  
Paddy Ssentongo ◽  
Robert Beelman ◽  
Xiang Gao ◽  
John Richie
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Confidence Intervals ◽  
Dose Response ◽  
Lower Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Low Risk ◽  
Case Control Studies ◽  
Risk Of Cancer

Abstract Objectives The potential health benefits associated with mushroom consumption, including reductions in risk of cancer have gained recent research attention. We thus conducted a systematic review and meta-analysis to assess the association between mushrooms intake and risk of cancer at any site. Methods We searched MEDLINE, Web of Science, and Cochrane Library to identify relevant studies on mushrooms intake and cancer published from January 1, 1966 to October 1, 2019.  Observational studies with relative risks (RRs) or hazard ratios (HRs) or odds ratios (ORs) and 95% confidence intervals (CIs) of cancer risk for two or more categories of mushroom intake were eligible for the present studies.  Random-effects models were used to pool study results and to assess dose-response relationships between mushroom consumption and the risk of cancer. Results There were 17 studies (6 cohort and 11 case-control studies) for a total of 20,797 cancer cases. Mushroom consumption was associated with lower risk of cancer – the pooled RR was 0.66 (95% Confidence Intervals (CI): 0.55–0.78) for the highest vs lowest mushroom intakes groups. There was substantial heterogeneity between studies (I2 = 77%; p for heterogeneity < 0.01). Mushroom consumption was associated with lower risk of cancer in cohort studies (RR = 0.90, 95% CI: 0.82–0.99; n = 6)  and case-control studies (RR = 0.52, 95% CI: 0.41–0.66; n = 11). Subgroup analysis showed that the significant mushroom cancer association was only observed in studies from non-western regions (RR = 0.58, 95% CI: 0.47–0.71, p = 0.02; n = 14). Mushroom  consumption was associated with low risk of  breast cancer (RR = 0.65, 95% CI: 0.52–0.81) compared to non-breast cancer. Dose-response analysis suggested that 10 g/day increase in mushroom intakes was associated with a 17% lower risk of cancer (RR = 0.83, 95% CI: 0.73–0.96, P-trend = 0.01). Conclusions The current meta-analysis showed a significant inverse association between greater mushroom consumption and low risk of cancer. In particular, breast cancer appeared to be the most affected site as significant association with mushroom intake were only observed for cancers at this site. Large prospective studies, ideally randomized  controlled trials, are needed to investigate the association between mushrooms intake and risk of cancer. Funding Sources There was no external or internal funding to support this study.

scholarly journals Hypertension and the risk of endometrial cancer: a systematic review and meta-analysis of case-control and cohort studies

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Dagfinn Aune ◽  
Abhijit Sen ◽  
Lars J. Vatten
Keyword(s):  
Systematic Review ◽  
Endometrial Cancer ◽  
Cohort Studies ◽  
Contraceptive Use ◽  
Meta Analysis ◽  
Case Control ◽  
Adjusted Relative Risk ◽  
Case Control Studies ◽  
Relative Risks ◽  
Increased Risk

Abstract A history of hypertension has been associated with increased risk of endometrial cancer in several studies, but the results have not been consistent. We conducted a systematic review and meta-analysis of case-control and cohort studies to clarify the association between hypertension and endometrial cancer risk. PubMed and Embase databases were searched up to 27th of February 2016. Prospective and case-control studies which reported adjusted relative risk estimates and 95% confidence intervals of endometrial cancer associated with a hypertension diagnosis were included. Summary relative risks were estimated using a random effects model. Nineteen case-control studies and 6 cohort studies were included. The summary RR was 1.61 (95% CI: 1.41–1.85, I2 = 86%) for all studies, 1.73 (95% CI: 1.45–2.06, I2 = 89%) for case-control studies and 1.32 (95% CI: 1.12–1.56, I2 = 47%) for cohort studies. The association between hypertension and endometrial cancer was weaker, but still significant, among studies with adjustment for smoking, BMI, oral contraceptive use, and parity, compared to studies without such adjustment. This meta-analysis suggest an increased risk of endometrial cancer among patients with hypertension, however, further studies with more comprehensive adjustments for confounders are warranted to clarify the association.

scholarly journals Association between green tea intake and risk of gastric cancer: a systematic review and dose–response meta-analysis of observational studies

2017 ◽  
Vol 20 (17) ◽  
pp. 3183-3192 ◽  
Author(s):  
Yanhong Huang ◽  
Hongru Chen ◽  
Liang Zhou ◽  
Gaoming Li ◽  
Dali Yi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
High Temperature ◽  
Relative Risk ◽  
Green Tea ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

AbstractObjectiveTo examine and quantify the potential dose–response relationship between green tea intake and the risk of gastric cancer.DesignWe searched PubMed, EMBASE, Web of Science, CBM, CNKI and VIP up to December 2015 without language restrictions.SettingA systematic review and dose–response meta-analysis of observational studies.SubjectsFive cohort studies and eight case–control studies.ResultsCompared with the lowest level of green tea intake, the pooled relative risk (95 % CI) of gastric cancer was 1·05 (0·90, 1·21, I2=20·3 %) for the cohort studies and the pooled OR (95 % CI) was 0·84 (0·74, 0·95, I2=48·3 %) for the case–control studies. The pooled relative risk of gastric cancer was 0·79 (0·63, 0·97, I2=63·8 %) for intake of 6 cups green tea/d, 0·59 (0·42, 0·82, I2=1·0 %) for 25 years of green tea intake and 7·60 (1·67, 34·60, I2=86·5 %) for drinking very hot green tea.ConclusionsDrinking green tea has a certain preventive effect on reducing the risk of gastric cancer, particularly for long-term and high-dose consumption. Drinking too high-temperature green tea may increase the risk of gastric cancer, but it is still unclear whether high-temperature green tea is a risk factor for gastric cancer. Further studies should be performed to obtain more detailed results, including other gastric cancer risk factors such as smoking and alcohol consumption and the dose of the effective components in green tea, to provide more reliable evidence-based medical references for the relationship between green tea and gastric cancer.

scholarly journals Association of Dietary Cholesterol Intake With Risk of Gastric Cancer: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
Vol 8 ◽  
Author(s):  
Peng Miao ◽  
Lin Guan
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Dietary Cholesterol ◽  
Case Control ◽  
The Body ◽  
Case Control Studies ◽  
Cholesterol Intake

Background: Many case–control studies have investigated the association between dietary cholesterol and gastric cancer, yielding inconsistent findings. We carried out a systematic review and meta-analysis of observational studies to assess the relationship between dietary cholesterol intake and gastric cancer among adults.Methods: PubMed, Scopus, and Google Scholar were systematically searched to identify articles that evaluated the association of dietary cholesterol with gastric cancer up to May 2021. Pooled odds ratio (ORs) and 95% confidence intervals (CIs) were computed using random-effects models. Dose–response analysis was used to explore the shape and strength of the association.Results: Fourteen case–control studies with 6,490 gastric cancer patients and 17,793 controls met our inclusion criteria. In the meta-analysis of the highest vs. the lowest dietary cholesterol categories, a significantly higher (~35%) risk of gastric cancer was observed in association with high cholesterol consumption (pooled OR: 1.35, 95% CI: 1.29–1.62, I2 = 68%; 95%CI: 45–81%). Subgroup analysis also showed this positive relationship in population-based case–control studies, those conducted on non-US countries, those with a higher number of cases and high-quality studies, those that collected dietary data via interviews, studies not adjusted for Helicobacter pylori infection, and studies where the body mass index was controlled. Besides, a non-linear dose–response association was also identified (P = 0.03).Conclusion: This study demonstrated that dietary cholesterol intake could significantly augment the risk of gastric cancer in case–control studies. Prospective cohort studies with large sample sizes and long durations of follow-up are required to verify our results.

Abstract MP003: Alpha-linolenic Acid Intake and Biomarker in Relation to Risk of Cardiovascular Disease: A Meta-analysis and Systematic Review

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
An Pan ◽  
Mu Chen ◽  
Rajiv Chowdhury ◽  
Jason Wu ◽  
Qi Sun ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Adipose Tissue ◽  
Cohort Studies ◽  
Dose Response ◽  
Prospective Cohort ◽  
Lower Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Alpha Linolenic Acid

Introduction: Several studies have investigated the association between the plant-based omega-3 alpha-linolenic acid (ALA) and risk of cardiovascular disease (CVD); however, results remain largely inconsistent. We have conducted a meta-analysis of all available epidemiological studies reporting on association between ALA consumption or its biomarker composition and risk of CVD. Methods: A search of MEDLINE, EMBASE, Web of Science, Cochrane Library and clinical trial registry databases (to February 2011) was supplemented by manual searches of bibliographies of retrieved articles and relevant reviews. Prospective cohort or case-control studies were included if they reported the association between ALA (assessed in dietary intake, and as circulating blood or adipose tissue biomarker) and CVD (including myocardial infarction [MI], sudden cardiac arrest, acute coronary syndrome, and stroke). Multivariate-adjusted risk estimate in each study was converted to relative risk (RR) comparing the top vs. bottom thirds of ALA, and were combined using fixed-effect models given that heterogeneity was not detected in most situations. A fixed-effect dose-response meta-analysis was conducted if data were available. Results: Fifteen prospective cohort and 12 case-control studies were identified with aggregate data on 188,896 individuals and 12,233 total CVD events. Comparing the top to bottom thirds, a higher ALA intake was associated with a lower risk of CVD death (RR=0.80; 95% CI 0.67–0.96; 6 cohort studies), but not non-fatal MI (RR=0.95; 95% CI 0.85–1.06; 1 cohort and 2 case-control studies), or total CVD (RR=0.93; 95% CI 0.85–1.02; 1 case-control and 6 cohort studies). Higher ALA biomarker levels in adipose tissues, plasma or serum (top vs. bottom thirds) were inversely associated with non-fatal MI (RR=0.75; 95% CI 0.62–0.92; 7 case-control studies), but not CVD death (RR=1.20; 95% CI 0.98–1.46; 1 case-control and 2 cohort studies) or total CVD (RR=0.89; 95% CI 0.75–1.04; 4 cohort and 3 case-control studies). In the dose-response meta-analyses, each 1 g/d increment of ALA intake was associated with a 10% lower risk of CVD death (RR=0.90; 95% CI 0.83–0.99; 5 cohort studies), and each 0.5% increment of adipose tissue ALA concentration was associated with a 21% (RR=0.79; 95% CI 0.70–0.89; 5 case-control studies) lower risk of non-fatal MI. Conclusion: Higher dietary ALA intakes are associated with a lower risk of CVD death, while higher ALA biomarker levels are associated with a lower risk of non-fatal MI. These findings highlight the need for additional well-designed observational studies as well as large randomized clinical trials to evaluate effects of ALA on CVD.

Dietary Inflammatory Index and Pancreatic Cancer Risk—A Systematic Review and Dose-response Meta-analysis

2021 ◽  
pp. 1-24
Author(s):  
Zhangyou Guo ◽  
Yuan Hong ◽  
Yao Cheng
Keyword(s):  
Systematic Review ◽  
Pancreatic Cancer ◽  
Dose Response ◽  
Meta Analysis ◽  
Case Control ◽  
Cochrane Library ◽  
Dietary Inflammatory Index ◽  
Case Control Studies ◽  
Inflammatory Index ◽  
Incident Cases

Abstract Objective: The meta-analysis was conducted to test the link between pancreatic cancer (PC) risk and dietary inflammatory index (DII®) score. Design: Systematic review and meta-analysis. Setting: We searched PubMed, Embase, Web of Science, and the Cochrane Library up to November 22, 2020, to identify the relevant studies. Studies that reported the risk estimates and the corresponding 95% confidence intervals (CIs) for the DII category and PC risk were included. The effect sizes were pooled using the random-effects model. Dose–response analysis was conducted where possible. Participants: Two prospective cohort studies of 634 705 participants (3 152 incident cases), and four case-control studies of 2 737 cases and 4 861 controls. Results: Overall, the pooled risk ratio (RR) indicated that individuals in the highest category compared with the lowest category had an increased PC risk (RR=1.45; 95% CI 1.11, 1.90; P=0.006). Meanwhile, significant heterogeneity was also revealed. The dose-response meta-analysis indicated that a 1-unit increase in the DII score was associated with the PC risk (RR=1.08; 95% CI 1.002, 1.166; P=0.045; I 2 =94.1%, P<0.001). Nonlinear result showed an increased risk of moving from fewer to more inflammatory borders with increasing DII score (Pnonlinearity = 0.003; I 2 =76.5%, P<0.001). Subgroup analyses found that significant positive association between PC risk and DII score appeared to be in case-control studies (RR=1.70; 95% CI 1.16, 2.50; P=0.007) and studies with ≤31 DII components (RR=1.76; 95% CI 1.14, 2.72; P=0.011). Conclusion: These findings suggested dietary habits with high inflammatory features (high DII score) might increase PC risk.

scholarly journals Light at night and risk of breast cancer: a systematic review and dose–response meta-analysis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Teresa Urbano ◽  
Marco Vinceti ◽  
Lauren A. Wise ◽  
Tommaso Filippini
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Breast Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Premenopausal Women ◽  
Positive Association ◽  
Case Control ◽  
Case Control Studies ◽  
Light At Night

AbstractBreast cancer is the most common malignancy in women and the second leading cause of cancer death overall. Besides genetic, reproductive, and hormonal factors involved in disease onset and progression, greater attention has focused recently on the etiologic role of environmental factors, including exposure to artificial lighting such as light-at-night (LAN). We investigated the extent to which LAN, including outdoor and indoor exposure, affects breast cancer risk. We performed a systematic review of epidemiological evidence on the association between LAN exposure and breast cancer risk, using a dose–response meta-analysis to examine the shape of the relation. We retrieved 17 eligible studies through September 13, 2021, including ten cohort and seven case–control studies. In the analysis comparing highest versus lowest LAN exposure, we found a positive association between exposure and disease risk (risk ratio [RR] 1.11, 95% confidence interval-CI 1.07–1.15), with comparable associations in case–control studies (RR 1.14, 95% CI 0.98–1.34) and cohort studies (RR 1.10, 95% CI 1.06–1.15). In stratified analyses, risk was similar for outdoor and indoor LAN exposure, while slightly stronger risks were observed for premenopausal women (premenopausal: RR 1.16, 95% CI 1.04–1.28; postmenopausal: 1.07, 95% CI 1.02–1.13) and for women with estrogen receptor (ER) positive breast cancer (ER + : RR 1.09, 95% CI 1.02–1.17; ER–: RR 1.07, 95% CI 0.92–1.23). The dose–response meta-analysis, performed only in studies investigating outdoor LAN using comparable exposure assessment, showed a linear relation up to 40 nW/cm2/sr after which the curve flattened, especially among premenopausal women. This first assessment of the dose–response relation between LAN and breast cancer supports a positive association in selected subgroups, particularly in premenopausal women.

Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis

2021 ◽  
pp. 1-13
Author(s):  
Shu Wang ◽  
Xiang Li ◽  
Yue Yang ◽  
Jingping Xie ◽  
Mingyue Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Postmenopausal Women ◽  
Meta Analysis ◽  
High Dose ◽  
Dependent Manner ◽  
Tea Consumption ◽  
Case Control Studies ◽  
High Concentration ◽  
Coffee Intake

Abstract Objective: We aimed to evaluate the association between coffee and/or tea consumption and breast cancer (BC) risk among premenopausal and postmenopausal women and to conduct a network meta-analysis. Design: Systematic review and network meta-analysis. Setting: We conducted a systematic review of electronic publications in the last 30 years to identify case–control studies or prospective cohort studies that evaluated the effects of coffee and tea intake. Results: Forty-five studies that included more than 3 323 288 participants were eligible for analysis. Network meta-analysis was performed to determine the effects of coffee and/or tea consumption on reducing BC risk in a dose-dependent manner and differences in coffee/tea type, menopause status, hormone receptor and the BMI in subgroup and meta-regression analyses. According to the first pairwise meta-analysis, low-dose coffee intake and high-dose tea intake may exhibit efficacy in preventing ER(estrogen receptor)− BC, particularly in postmenopausal women. Then, we performed another pairwise and network meta-analysis and determined that the recommended daily doses were 2–3 cups/d of coffee or ≥5 cups/d of tea, which contained a high concentration of caffeine, particularly in postmenopausal women. Conclusions: Coffee and tea consumption is not associated with a reduction in the overall BC risk in postmenopausal women and is associated with a potentially lower risk of ER− BC. And the highest recommended dose is 2–3 cups of coffee/d or ≥5 cups of tea/d. They are potentially useful dietary protectants for preventing BC.

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