scholarly journals Mapping the adrenal lipid depletion gene of the AKR/J mouse strain

1975 ◽  
Vol 26 (3) ◽  
pp. 307-312 ◽  
Author(s):  
B. A. Taylor ◽  
H. Meier
Keyword(s):  
Gene Order ◽  
Mouse Strain ◽  
Recombinant Inbred ◽  
Autosomal Recessive ◽  
Inbred Mouse ◽  
Chromosome 1 ◽  
Backcross Generation ◽  
Recombinant Inbred Mouse ◽  
Mouse Lines

SUMMARYThe pattern of inheritance of the autosomal recessive adrenal lipid depletion (ald) allele among the AKXL recombinant inbred mouse lines, derived from a cross between AKR/J and C57L/J, revealed that the ald locus is located on chromosome 1 near the dipeptidase-1 (Dip-1) locus. The linkage was confirmed in a backcross generation and the gene order ln-Dip-1-ald was established.

Fibrogenic genotype-phenotype correlations in selected BXD recombinant inbred mouse lines: Closer to life?!

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
N Fund ◽  
R Hall ◽  
S Dooley ◽  
F Lammert ◽  
R Müllenbach
Keyword(s):  
Recombinant Inbred ◽  
Inbred Mouse ◽  
Recombinant Inbred Mouse ◽  
Mouse Lines

scholarly journals Working memory and pattern separation in founder strains of the BXD recombinant inbred mouse panel

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Price E. Dickson ◽  
Guy Mittleman
Keyword(s):  
Working Memory ◽  
Mouse Strain ◽  
Cognitive Abilities ◽  
Recombinant Inbred ◽  
Inbred Mouse ◽  
Strain Differences ◽  
Pattern Separation ◽  
Horizontal Distance ◽  
Recombinant Inbred Mouse ◽  
Genetic Mechanisms

AbstractWorking memory and pattern separation are fundamental cognitive abilities which, when impaired, significantly diminish quality of life. Discovering genetic mechanisms underlying innate and disease-induced variation in these cognitive abilities is a critical step towards treatments for common and devastating neurodegenerative conditions such as Alzheimer's disease. In this regard, the trial-unique nonmatching-to-location assay (TUNL) is a touchscreen operant conditioning procedure allowing simultaneous quantification of working memory and pattern separation in mice and rats. In the present study, we used the TUNL assay to quantify these cognitive abilities in C57BL/6J and DBA/2J mice. These strains are the founders of the BXD recombinant inbred mouse panel which enables discovery of genetic mechanisms underlying phenotypic variation. TUNL testing revealed that pattern separation was significantly influenced by mouse strain, whereas working memory was not. Moreover, horizontal distance and vertical distance between choice-phase stimuli had dissociable effects on TUNL performance. These findings provide novel data on mouse strain differences in pattern separation and support previous findings of equivalent working memory performance in C57BL/6J and DBA/2J mice. Although working memory of the BXD founder strains was equivalent in this study, working memory of BXD strains may be divergent because of transgressive segregation. Collectively, data presented here indicate that pattern separation is heritable in the mouse and that the BXD panel can be used to identify mechanisms underlying variation in pattern separation.

scholarly journals Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes

2009 ◽  
Vol 106 (6) ◽  
pp. 2047-2052 ◽  
Author(s):  
Ana M. D. Carneiro ◽  
David C. Airey ◽  
Brent Thompson ◽  
Chong-Bin Zhu ◽  
Lu Lu ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Recombinant Inbred ◽  
Inbred Mouse ◽  
Recombinant Inbred Mouse ◽  
Mouse Lines

Towards mouse models of perseveration: A heritable component in extinction of operant behavior in fourteen standard and recombinant inbred mouse lines

2011 ◽  
Vol 96 (2) ◽  
pp. 280-287 ◽  
Author(s):  
Hemi A.I. Malkki ◽  
Laura A.B. Donga ◽  
Sabine E. de Groot ◽  
Francesco P. Battaglia ◽  
Cyriel M.A. Pennartz
Keyword(s):  
Mouse Models ◽  
Recombinant Inbred ◽  
Operant Behavior ◽  
Inbred Mouse ◽  
Recombinant Inbred Mouse ◽  
Mouse Lines

Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain

2013 ◽  
Vol 236 ◽  
pp. 283-288 ◽  
Author(s):  
Caroline A. Browne ◽  
Gerard Clarke ◽  
Joachim Hanke ◽  
Timothy G. Dinan ◽  
Herbert Schwegler ◽  
...  
Keyword(s):  
Mouse Strain ◽  
Recombinant Inbred ◽  
Inbred Mouse ◽  
Inbred Mouse Strain ◽  
Recombinant Inbred Mouse ◽  
Prefrontal Cortical ◽  
Recombinant Inbred Mouse Strain
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