Decreased nasal nitric oxide levels: A potential marker of decreased olfactory discrimination in chronic rhinosinusitis

2021 ◽  
pp. 1-28
Author(s):  
Lichuan Zhang ◽  
Fang Fang ◽  
Linyin Yao ◽  
Haili Sun ◽  
Xiaojun Zhan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Olfactory Discrimination ◽  
Nasal Nitric Oxide ◽  
Potential Marker

scholarly journals Eosinophilic inflammation of the paranasal sinuses and reduced nasal nitric oxide levels in patients with chronic rhinosinusitis

2018 ◽  
Vol 141 (2) ◽  
pp. AB270
Author(s):  
Kanako Yoshida ◽  
Tetsuji Takabayashi ◽  
Masafumi Sakashita ◽  
Yoshimasa Imoto ◽  
Norihiko Narita ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Paranasal Sinuses ◽  
Eosinophilic Inflammation ◽  
Nasal Nitric Oxide

scholarly journals Perspective of the regulatory and functional roles of nasal nitric oxide in chronic rhinosinusitis

2019 ◽  
Vol 37 (4) ◽  
pp. 233-239
Author(s):  
Kota Takemoto ◽  
Sachio Takeno ◽  
Atsuko Ohtani ◽  
Daisuke Takahara ◽  
Manabu Nishida ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Functional Roles ◽  
Nasal Nitric Oxide

Predictive and Diagnostic Value of Nasal Nitric Oxide in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

2020 ◽  
Vol 181 (11) ◽  
pp. 853-861
Author(s):  
Hao Lv ◽  
Pei-Qiang Liu ◽  
Rong Xiang ◽  
Wei Zhang ◽  
Shi-Ming Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Upper Airway ◽  
Central China ◽  
Clinical Parameters ◽  
Total Ige ◽  
Nasal Nitric Oxide ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Plasma Cytokines

<b><i>Background:</i></b> A hallmark of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is mucosal eosinophil-predominant inflammation. Nasal nitric oxide (nNO) is a known biomarker of eosinophilic inflammation in the upper airway. However, the utility of nNO measurement in the upper airway remains controversial. The present study aimed to compare the use of other clinical parameters with nNO to prediagnose patients with eCRSwNP from Central China. <b><i>Methods:</i></b> From June 2019 to December 2019, 70 patients with CRSwNP undergoing endoscopic sinus surgery and 30 healthy subjects were enrolled. nNO measurements were performed in all of these subjects. Computed tomography scans, full blood count with differential analysis, and determination of total immunoglobulin E (total IgE) and plasma cytokines were performed before surgery. Receiver operating characteristic curves and logistic regression analysis were used to assess the predictive potential of the clinical parameters. <b><i>Results:</i></b> We recruited 24 patients with eCRSwNP and 46 with noneosinophilic CRSwNP (non-eCRSwNP). In patients with eCRSwNP, nNO levels were significantly higher than those in patients with non-eCRSwNP (<i>p</i> &#x3c; 0.0001). Blood eosinophil percentages and counts, total IgE, and CT-derived ethmoid sinus and maxillary sinus ratio (E/M ratio) were all significantly higher compared with those in patients with non-eCRSwNP (<i>p</i> &#x3c; 0.05). To diagnose eCRSwNP, the highest area under the curve (0.803) was determined for nNO. At a cutoff of &#x3e;329 parts per billion (ppb), the sensitivity was 83.30% and the specificity was 71.70%. However, the levels of plasma cytokines Th1/Th2 were not significantly different between the histological types of CRSwNP (<i>p</i> &#x3e; 0.05). <b><i>Conclusion:</i></b> Measurement of nNO is useful for the early diagnosis of eCRSwNP.

scholarly journals Correlation of Nasal Nitric Oxide Measurement with Computed Tomography Findings in Chronic Rhinosinusitis

2013 ◽  
Vol 66 (1) ◽  
pp. 92-96 ◽  
Author(s):  
Yogesh G. Dabholkar ◽  
Akanksha A. Saberwal ◽  
Haritosh K. Velankar ◽  
Adip K. Shetty ◽  
Nilesh P. Chordia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Computed Tomography ◽  
Chronic Rhinosinusitis ◽  
Nasal Nitric Oxide

scholarly journals Reduced nasal nitric oxide levels in patients with eosinophilic chronic rhinosinusitis

2019 ◽  
Vol 68 (2) ◽  
pp. 225-232 ◽  
Author(s):  
Kanako Yoshida ◽  
Tetsuji Takabayashi ◽  
Yoshimasa Imoto ◽  
Masafumi Sakashita ◽  
Norihiko Narita ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Nasal Nitric Oxide ◽  
Eosinophilic Chronic Rhinosinusitis

scholarly journals Measurement of Nasal Nitric Oxide in Chronic Rhinosinusitis and Its Relationship to Patient-Reported Outcome: A Longitudinal Pilot Study

2019 ◽  
pp. 014556131988062 ◽  
Author(s):  
Cecilia Alexandersson ◽  
Lisa Tuomi ◽  
Anna-Carin Olin
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Statistical Significance ◽  
Measurement Techniques ◽  
Control Group ◽  
Healthy Controls ◽  
Nasal Nitric Oxide ◽  
Patient Reported ◽  
Significant Change ◽  
Snot 22

Objective: To assess whether nasal nitric oxide (nNO) levels differ between healthy and sick sinuses in chronic rhinosinusitis (CRS). A secondary aim was to assess whether nNO levels change after treatment of CRS and whether there is an association with radiological findings or symptoms. Method: Three groups of 12 participants each were examined: patients with CRS without polyposis (CRS group), patients with symptoms of CRS but radiologically normal sinuses (symptoms-only), and healthy controls. Measurements of nNO were carried out using aspiration method and humming maneuver. All participants completed the Sino-Nasal Outcome Test (SNOT-22). A second nNO measurement was done after treatment in the CRS group (n = 9) and the healthy control group (n = 12). Results: Nasal NO did not differ between any of the groups with any of the measurement techniques. There was a trend toward lower nNO values in the CRS group compared with the symptoms-only group and healthy controls, but it did not reach statistical significance. The SNOT-22 demonstrated inferior values for the CRS and symptoms-only groups compared with the healthy controls. At follow-up, no statistically significant change was found for the nNO measurements in either group. Conclusion: Irrespective of occluded or open ostiomeatal complexes, no statistically significant differences in nNO were found in CRS compared with healthy controls using aspiration and humming methods. Treatment of CRS improved sinus patency without accompanying a significant change in nNO. This study can therefore not conclude that nNO can be used as a diagnostic tool for CRS without polyposis.

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