scholarly journals Salmon in pregnancy study (SIPS): the effects of increased oily fish intake during pregnancy on maternal peripheral blood mononuclear cell fatty acid composition and cytokine responses

2010 ◽  
Vol 69 (OCE3) ◽  
Author(s):  
L.-S. Kremmyda ◽  
M. Vlachava ◽  
P. S. Noakes ◽  
E. A. Miles ◽  
N. D. Diaper ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Peripheral Blood Mononuclear Cell ◽  
Peripheral Blood ◽  
Fish Intake ◽  
Peripheral Blood Mononuclear ◽  
Cytokine Responses ◽  
Maternal Peripheral Blood ◽  
Oily Fish ◽  
In Pregnancy

scholarly journals Association of oily fish intake, sex, age, BMI and APOE genotype with plasma long-chain n-3 fatty acid composition

2018 ◽  
Vol 120 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Helena L. Fisk ◽  
Michael Irvine ◽  
Elizabeth A. Miles ◽  
Georg Lietz ◽  
John C. Mathers ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Plasma Lipids ◽  
Apoe Genotype ◽  
Plasma Lipid ◽  
Dietary Exposure ◽  
Positive Association ◽  
Fish Intake ◽  
Oily Fish

Abstractn-3 Fatty acids are associated with better cardiovascular and cognitive health. However, the concentration of EPA, DPA and DHA in different plasma lipid pools differs and factors influencing this heterogeneity are poorly understood. Our aim was to evaluate the association of oily fish intake, sex, age, BMI and APOE genotype with concentrations of EPA, DPA and DHA in plasma phosphatidylcholine (PC), NEFA, cholesteryl esters (CE) and TAG. Healthy adults (148 male, 158 female, age 20–71 years) were recruited according to APOE genotype, sex and age. The fatty acid composition was determined by GC. Oily fish intake was positively associated with EPA in PC, CE and TAG, DPA in TAG, and DHA in all fractions (P≤0·008). There was a positive association between age and EPA in PC, CE and TAG, DPA in NEFA and CE, and DHA in PC and CE (P≤0·034). DPA was higher in TAG in males than females (P<0·001). There was a positive association between BMI and DPA and DHA in TAG (P<0·006 and 0·02, respectively). APOE genotype×sex interactions were observed: the APOE4 allele associated with higher EPA in males (P=0·002), and there was also evidence for higher DPA and DHA (P≤0·032). In conclusion, EPA, DPA and DHA in plasma lipids are associated with oily fish intake, sex, age, BMI and APOE genotype. Such insights may be used to better understand the link between plasma fatty acid profiles and dietary exposure and may influence intake recommendations across population subgroups.

scholarly journals The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells

2007 ◽  
Vol 99 (1) ◽  
pp. 147-154 ◽  
Author(s):  
Camilla T. Damsgaard ◽  
Hanne Frøkiær ◽  
Lotte Lauritzen
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Chain Pufa ◽  
Blood Mononuclear Cells

Dietary intake of 18: 2n-6 and 18: 3n-3 may affect endogenous production and incorporation of n-3 long-chain PUFA (LCPUFA) from fish oils (FO). This double-blinded controlled 2 × 2-factorial 8-week intervention investigates the effects of high and low 18: 2n-6 intake in combination with FO-supplementation on tissue fatty acid composition. Healthy young men (n 64) were randomized to capsules with FO or olive oil (control) (4·4 (2·0–5·6) ml/d) and to either sunflower oil and margarine (S/B) or rapeseed oil and a butter spread (R/K) to provide a high or a low 18: 2n-6 intake. Diet was measured by 4-d weighed dietary records at baseline, during and 8 weeks after the intervention and tissue incorporation as fatty acid composition of peripheral blood mononuclear cells (PBMC). The fat intervention gave a mean difference in the 18: 2n-6 intake of 7·3 g/d (95 % CI 4·6, 10·0) and a similar 18: 3n-3 intake in the groups. The R/K groups had a 0·2 % fatty acid (FA%) (95 % CI 0·0, 0·4, P = 0·02) higher content of 22: 5n-3 in the PBMC, a tendency of slightly higher 20: 5n-3 (P = 0·06), but no more 22: 6n-3 (P = 0·83) than the S/B groups. FO effectively raised the PBMC content of all n-3 LCPUFA (P < 0·001). The fat intervention did not markedly influence the effect of FO; the mean PBMC content of n-3 LCPUFA was 10·3 (sem 0·3) FA% in the FO+S/B group and 10·6 (sem 0·2) FA% in the FO+R/K group. In conclusion, increasing the 18: 2n-6 intake did not have any pronounced effect on incorporation of n-3 LCPUFA in PBMC, either alone or with simultaneous FO supplementation.

scholarly journals Immune cell membrane fatty acids and inflammatory marker, C-reactive protein, in patients with multiple sclerosis

2009 ◽  
Vol 102 (9) ◽  
pp. 1334-1340 ◽  
Author(s):  
Gloudina Hon ◽  
Mogamat Hassan ◽  
Susan Janse van Rensburg ◽  
Stefan Abel ◽  
De Wet Marais ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
C Reactive Protein ◽  
Peripheral Blood Mononuclear ◽  
Reactive Protein ◽  
Multiple Sclerosis Patients

Measurement of fatty acids in biological fluids and cell membranes including leucocytes from multiple sclerosis patients is inconsistent. The objective of the present study was to investigate the fatty acid composition within the different membrane phospholipid fractions in peripheral blood mononuclear cells in multiple sclerosis patients, and correlate with severity of neurological outcome as measured by the Kurtzke Expanded Disability Status Scale and Functional System Scores. The fatty acid composition of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin and phosphatidylinositol phospholipids in the peripheral blood mononuclear cells of twenty-six multiple sclerosis and twenty-five control subjects were measured by GC, and C-reactive protein was measured in all subjects. The elongation product of 20 : 4n-6, 22 : 4n-6, was significantly decreased in membrane phosphatidylethanolamine and phosphatidylserine in multiple sclerosis patients (P = 0·01 and P = 0·03 respectively), and correlated inversely with severity of disease and C-reactive protein. Also an inverse correlation was observed between the C-reactive protein and membrane phosphatidylcholine and phosphatidylserine 20 : 4n-6. Cultural and ethnic differences, as well as dietary variability, especially in a diseased state have been implicated in the differences observed in the fatty acid composition in peripheral blood mononuclear cell membranes of patients with multiple sclerosis. The present results suggest that the disease state may in part explain the reported inconsistencies in fatty acid levels in multiple sclerosis patients.

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