Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors

Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00022-5 ◽

2000 ◽

Vol 8 (5) ◽

pp. 1117-1128 ◽

Cited By ~ 93

Author(s):

Giulio Rastelli ◽

Worachart Sirawaraporn ◽

Pornthep Sompornpisut ◽

Tirayut Vilaivan ◽

Sumalee Kamchonwongpaisan ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Dihydrofolate Reductase ◽

Structural Basis ◽

Acta Crystallographica Section F Structural Biology and Crystallization Communications ◽

Two crystal structures of dihydrofolate reductase-thymidylate synthase fromCryptosporidium hominisreveal protein–ligand interactions including a structural basis for observed antifolate resistance

10.1107/s1744309105002435 ◽

2005 ◽

Vol 61 (3) ◽

pp. 258-262 ◽

Cited By ~ 19

Author(s):

Amy C. Anderson

Keyword(s):

Crystal Structures ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Structural Basis ◽

Protein Ligand Interactions ◽

Ligand Interactions ◽

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.84.23.8360 ◽

1987 ◽

Vol 84 (23) ◽

pp. 8360-8364 ◽

Cited By ~ 142

Author(s):

D. J. Bzik ◽

W. B. Li ◽

T. Horii ◽

J. Inselburg

Keyword(s):

Plasmodium Falciparum ◽

Sequence Analysis ◽

Molecular Cloning ◽

Dihydrofolate Reductase ◽

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.87.8.3014 ◽

1990 ◽

Vol 87 (8) ◽

pp. 3014-3017 ◽

Cited By ~ 175

Author(s):

S. J. Foote ◽

D. Galatis ◽

A. F. Cowman

Keyword(s):

Amino Acids ◽

Plasmodium Falciparum ◽

Dihydrofolate Reductase ◽

POINT MUTATIONS IN THE DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE GENE AS THE MOLECULAR BASIS OF PYRIMETHAMINE RESISTANCE IN PLASMODIUM FALCIPARUM

Retrospect and Prospect of Protein Research ◽

10.1142/9789814360425_0029 ◽

1991 ◽

pp. 153-158

Author(s):

GUOXIAN CHEN

Keyword(s):

Plasmodium Falciparum ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Molecular Basis ◽

Point Mutations

A complete model of the Plasmodium falciparum bifunctional enzyme dihydrofolate reductase-thymidylate synthase: a model to design new antimalarials

Journal of the Brazilian Chemical Society ◽

10.1590/s0103-50532004000300019 ◽

2004 ◽

Vol 15 (3) ◽

pp. 450-454 ◽

Cited By ~ 11

Author(s):

Tanos C. C. França ◽

André L. R. de Medeiros ◽

Edison C. P. dos Santos ◽

Osvaldo A. Santos-Filho ◽

José D. Figueroa-Villar

Keyword(s):

Plasmodium Falciparum ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Bifunctional Enzyme ◽

Complete Model

Molecular epidemiology of malaria in Yaounde, Cameroon. VI. Sequence variations in the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene and in vitro resistance to pyrimethamine and cycloguanil.

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.2000.62.271 ◽

2000 ◽

Vol 62 (2) ◽

pp. 271-276 ◽

Cited By ~ 26

Author(s):

L K Basco ◽

P Ringwald

Keyword(s):

Plasmodium Falciparum ◽

Molecular Epidemiology ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Sequence Variations

Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum

Molecular and Biochemical Parasitology ◽

10.1016/0166-6851(96)02647-3 ◽

1996 ◽

Vol 79 (2) ◽

pp. 153-165 ◽

Cited By ~ 72

Author(s):

John R. Vásquez ◽

Lisa Goozé ◽

Kami Kim ◽

Jiří Gut ◽

Carolyn Petersen ◽

...

Keyword(s):

Cryptosporidium Parvum ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Genotypic Variation ◽

Resistance Determinants ◽

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.85.23.9109 ◽

1988 ◽

Vol 85 (23) ◽

pp. 9109-9113 ◽

Cited By ~ 290

Author(s):

A. F. Cowman ◽

M. J. Morry ◽

B. A. Biggs ◽

G. A. Cross ◽

S. J. Foote

Keyword(s):

Plasmodium Falciparum ◽

Amino Acid ◽

Dihydrofolate Reductase ◽

Chemical synthesis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

Molecular and Biochemical Parasitology ◽

10.1016/s0166-6851(96)02756-9 ◽

1996 ◽

Vol 83 (1) ◽

pp. 93-106 ◽

Cited By ~ 19

Author(s):

Phisit Prapunwattana ◽

Worachart Sirawaraporn ◽

Yongyuth Yuthavong ◽

Daniel V. Santi

Keyword(s):

Plasmodium Falciparum ◽

Chemical Synthesis ◽

Dihydrofolate Reductase ◽