Genetic factors in the sex ratio of major depression

1985 ◽  
Vol 15 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Kathleen R. Merikangas ◽  
Myrna M. Weissman ◽  
David L. Pauls
Keyword(s):  
Major Depression ◽  
Sex Ratio ◽  
Genetic Study ◽  
Genetic Factors ◽  
Twofold Increase ◽  
Prevalence Of Depression ◽  
Genetic Loading

SynopsisA twofold increase in the prevalence of depression among women has been consistently observed. Several possible explanations, including methodological, endocrine, psychosocial, and genetic factors, have been proposed for the increased rates of depression among women. This paper describes the analysis of data from a family-genetic study of depressed probands to examine whether genetic factors can explain the preponderance of depressed females. Our data indicate that the excess of females with major depression cannot be attributed to increased genetic loading for depression in women. Other factors which may explain increased rates of major depression in women are discussed.

Major Depression and Generalised Anxiety Disorder

1996 ◽  
Vol 168 (S30) ◽  
pp. 68-75 ◽  
Author(s):  
Kenneth S. Kendler
Keyword(s):  
Risk Factors ◽  
Anxiety Disorder ◽  
Major Depression ◽  
Environmental Risk ◽  
Genetic Factors ◽  
Environmental Risk Factors ◽  
Generalised Anxiety Disorder ◽  
Increase Risk ◽  
Twin Models ◽  
One Year

In both clinical and epidemiological samples, major depression (MD) and generalised anxiety disorder (GAD) display substantial comorbidity. In a prior analysis of lifetime MD and GAD in female twins, the same genetic factors were shown to influence the liability to MD and to GAD. A follow-up interview in the same twin cohort examined one-year prevalence for MD and GAD (diagnosed using a one-month minimum duration of illness). Bivariate twin models were fitted using the program Mx. High levels of comorbidity were observed between MD and GAD. The best-fitting twin models, when GAD was diagnosed with or without a diagnostic hierarchy, found a genetic correlation of unity between the two disorders. The correlation in environmental risk factors was +0.70 when GAD was diagnosed non-hierarchically, but zero when hierarchical diagnoses were used. Our findings provide further support for the hypothesis that in women, MD and GAD are the result of the same genetic factors. Environmental risk factors that predispose to ‘pure’ GAD episodes may be relatively distinct from those that increase risk for MD.

Affective Disorders Among Elderly General Practice Patients

1994 ◽  
Vol 165 (4) ◽  
pp. 533-537 ◽  
Author(s):  
C. Turrina ◽  
R. Caruso ◽  
R. Este ◽  
F. Lucchi ◽  
G. Fazzari ◽  
...  
Keyword(s):  
General Practice ◽  
Major Depression ◽  
Elderly Patients ◽  
General Practitioners ◽  
Affective Disorders ◽  
Dysthymic Disorder ◽  
Not Otherwise Specified ◽  
Prevalence Of Depression ◽  
General Practices

BackgroundWe investigated the prevalence of depression among 255 elderly general practice patients and the practitioners' performance in identifying depression.MethodElderly patients attending 14 general practices entered a screening phase with GHQ-12 and MMSE. Those positive were then interviewed with GMS and HAS.ResultsDSM-III-R major depression affected 22.4%, dysthymic disorder 6.3%, not otherwise specified (n.o.s.) depression 7.1 %. General practitioners performed fairly well: identification index 88.4%, accuracy 0.49, bias 1.85.ConclusionsDepression was markedly high. A selective progression of depressed elderly from the community to general practitioners is implied.

scholarly journals Sexually selected females in the monogamous Western Australian seahorse

2006 ◽  
Vol 274 (1609) ◽  
pp. 521-525 ◽  
Author(s):  
Charlotta Kvarnemo ◽  
Glenn I Moore ◽  
Adam G Jones
Keyword(s):  
Sexual Selection ◽  
Sex Ratio ◽  
Mating System ◽  
Genetic Study ◽  
Mating Success ◽  
Male Preference ◽  
Monogamous Species ◽  
Adult Sex Ratio ◽  
Western Australian ◽  
Selection Differentials

Studies of sexual selection in monogamous species have hitherto focused on sexual selection among males. Here, we provide empirical documentation that sexual selection can also act strongly on females in a natural population with a monogamous mating system. In our field-based genetic study of the monogamous Western Australian seahorse, Hippocampus subelongatus , sexual selection differentials and gradients show that females are under stronger sexual selection than males: mated females are larger than unmated ones, whereas mated and unmated males do not differ in size. In addition, the opportunity for sexual selection (variance in mating success divided by its mean squared) for females is almost three times that for males. These results, which seem to be generated by a combination of a male preference for larger females and a female-biased adult sex ratio, indicate that substantial sexual selection on females is a potentially important but under-appreciated evolutionary phenomenon in monogamous species.

Depression, Neuroticism, and Urinary Incontinence in Premenopausal Women: A Nationwide Twin Study

2013 ◽  
Vol 16 (5) ◽  
pp. 977-984 ◽  
Author(s):  
Giorgio Tettamanti ◽  
Daniel Altman ◽  
Anastasia N. Iliadou ◽  
Rino Bellocco ◽  
Nancy L. Pedersen
Keyword(s):  
Urinary Incontinence ◽  
Depressive Symptoms ◽  
Major Depression ◽  
Genetic Factors ◽  
Premenopausal Women ◽  
Phenotypic Correlation ◽  
Quantitative Genetic ◽  
Twin Registry ◽  
Comprehensive Survey ◽  
Swedish Twin Registry

Previous studies have found that major depression and neuroticism are positively associated with urinary incontinence (UI). However, the genetic contribution to these associations has never been investigated. In 2005, a total of 14,094 female twins born 1959–1985 in the Swedish Twin Registry participated in a comprehensive survey on common exposures and complex diseases. Structured questions provided information on UI, depressive symptoms, major depression, and neuroticism. A logistic regression model based on generalized estimating equations (GEE) was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Environmental and genetic influences were assessed in co-twin control analyses and quantitative genetic analyses, which were also used to determine the proportion of the phenotypic correlation explained by familial factors. Major depression, depressive symptoms, and neuroticism were positively associated with all UI subtypes (overall, stress, urge, and mixed UI). In a trivariate Cholesky model with neuroticism, depressive symptoms (or depression), and UI a modest genetic correlation was found between indicators of depression and overall, or stress, UI. The majority of this correlation was independent from neuroticism. In contrast, the genetic factors shared between indicators of depression and urge or mixed UI were entirely in common with neuroticism. In conclusion, depression and neuroticism are associated with UI among premenopausal women: the associations are in part determined by genetic factors in common to the disorders.

The prevalence of depression in patients with cushing’s syndrome

2011 ◽  
Vol 26 (S2) ◽  
pp. 620-620
Author(s):  
R. Danciulescu Miulescu ◽  
M.E. Calarasu ◽  
R.I. Rosca ◽  
S. Danoiu
Keyword(s):  
Major Depression ◽  
Cushing’S Syndrome ◽  
Depressive Symptomatology ◽  
Medical Condition ◽  
Depression Scale ◽  
Severe Depression ◽  
Cushing's Syndrome ◽  
Mild Depression ◽  
Prevalence Of Depression ◽  
Concomitant Medications

Background and aimsCushing's patients demonstrate major depression more than any other medical condition. Major depression is a common, complication of Cushing’s syndrome, with no significant differences between pituitary -dependent and -independent forms. The aims of the study is to estimate the prevalence of depression in patients with Cushing’s syndrome.Materials and methods23 patients with Cushing’s syndrome (14 with pituitary-dependent and 9 with pititary-independent forms) were recruited for this study. The subjects were between 52 and 67 years. Patients were screened initially with a questionnaire detailing their age, medical history, concomitant medications. The Zung self-rating depression scale was used to assess depressive symptomatology. It contains 20 items: index scores below 50 reflect no depression, 50–59 reflect mild depression, 60–69 reflect marked to moderate depression and scores of ≥ 70 reflect severe to extreme depression. Results were compared with measurements in 21 subjects without Cushing’s syndrome.ResultsThe prevalence of depression in patients with Cushing’s syndrome was 52.17% (12 patients). 2 patients (2 women) present mild depression and 10 patients (9 women and 1 men) present moderate or severe depression. Moderate or severe depression was significantly associated with older age, female sex, relatively more severe clinical condition. The prevalence of depression in 21 subjects without Cushing’s syndrome was 4.76% (1 women with mild depression).ConclusionThis study showed that patients with Cushing’s syndrome have a greater a risk of depression than people without Cushing’s syndrome. Patients with Cushing’s syndrome should be routinely screened and adequately treated for depression.

Studio Genetico sulla Ipertensione Essenziale e sui suoi Rapporti con la Cefalea Vascolare

1965 ◽  
Vol 14 (4) ◽  
pp. 376-391
Author(s):  
P. L. Malfanti ◽  
U. Bigozzi ◽  
A. Massi ◽  
C. Conti
Keyword(s):  
Essential Hypertension ◽  
Statistical Analysis ◽  
Young People ◽  
Old Age ◽  
Genetic Study ◽  
Genetic Factors ◽  
Young Female ◽  
Vascular Headache ◽  
Sex Preference ◽  
Female Subjects

SUMMARYA genetic study on a sample of patients suffering from essential hypertension has confirmed the inheritance of this disease. In single individuals and in families, especially in young female subjects, the same hereditary load often leads to the appearance of a vascular headache. In some family groups, the vascular headache seems to occur more frequently than in others. This fact suggests the hypothesis of a possible existence of factors able to favour the appearance of this trouble. After considering the data collected from the study of three generations of relatives of the hypertensive propositi, it seems possible to state that the hereditary load usually develops into vascular headache in young age, and hypertension in old age, while headache tends to disappear. This pattern, usually frequent, is not quite constant, and, in the same families, it is possible to find subjects affected with hypertension only, and others (also in old age) with headache only. Therefore, it is possible to think that the abovementioned diseases are pleiotropically determined by the same genetic factors, occurring in different ways, according to age, sex and other genotypic factors. The statistical analysis of the collected data suggests that such disease be inherited as a dominant monomeric autosomal trait, with a higher penetrance in old than in young people. Headache seems to prefer female subjects, while hypertension does not show any sex-preference.

The prevalence and factors associated with depression among preclinical and clinical medical students at King Saud bin Abdulaziz University for Health Sciences, Jeddah

2021 ◽  
Vol 2 (4) ◽  
pp. 1-12
Author(s):  
Sameer Yousof Rizg ◽  
◽  
Saleh Hani Alkhalid ◽  
Eiman Ramli Saleh ◽  
◽  
...  
Keyword(s):  
Medical Student ◽  
Medical Students ◽  
Major Depression ◽  
Rating Scale ◽  
Negative Impact ◽  
Health Sciences ◽  
Active Member ◽  
Depression Anxiety Stress Scale ◽  
Stress Scale ◽  
Prevalence Of Depression

Objectives - To assess the prevalence of major depression among medical students. - To assess the risk factors of major depression among medical students. Background: Depression, a common mental disorder which has been considered a serious problem worldwide. Depression has a great negative impact on different aspects of a person’s life such as school performance, work productivity, relationships with family and friends, and ability to participate and become an active member in the community Design: cross sectional study. Review Methods and Data Sources: A survey has been conduct seeking respondents’ level of agreement rating scale with a series of statements of two questionnaire sections: Depression Anxiety Stress Scale (DASS21), and Medical Student Stressor Questionnaire (MSSQ). Data gathered through an online questionnaire that designed through method mentioned above and distributed to preclinical and clinical medical students at King Saud bin Abdulaziz University for Health Sciences, Jeddah. The study will be conducted at King Saud Bin Abdulaziz University for Health Sciences- Jeddah, Saudi Arabia. Results: The prevalence of depression anxiety stress for study participants 11.6%. The prevalence of medical student stressor scale rich about 6.1%. There is significant different depression anxiety stress scale according to gender of participants. Top 10 Statements out of 21 of depression anxiety stress scale according to respondents’ opinions are: 1. I felt that I was using a lot of nervous energy. 2. I found it difficult to work up the initiative to do things. 3. I found it hard to wind down. 4. I found it difficult to relax. 5. I found myself getting agitated. 6. I was worried about situations in which I might panic and make a fool of myself. 7. I felt downhearted and blue. 8. I experienced trembling (eg, in the hands). 9. I was unable to become enthusiastic about anything. 10. I was aware of dryness of my mouth. Conclusion: This study was prompted by the rise in depression anxiety disorder is considered the leading cause of disability worldwide. The results and discussion sections presented high prevalence of depression anxiety stress rich 11.6% within the study sample of the preclinical and clinical medical students at King Saud bin Abdulaziz University for Health Sciences, Jeddah. Since the prevalence of medical student stressor rich 6.1% for same sample size.

Genetic factors in stress and major depression

2009 ◽  
pp. 55-66 ◽  
Author(s):  
Stephan Claes ◽  
Elisabeth B. Binder ◽  
Charles B. Nemeroff
Keyword(s):  
Major Depression ◽  
Genetic Factors
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