The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

scholarly journals Spermatogonial stem cell survival in ram lambs following busulfan treatment

2020 ◽  
Vol 17 (2) ◽  
Author(s):  
Mohammad Hadi Rasouli ◽  
Mohammad Zandi ◽  
Ali Asghar Sadeghi ◽  
Naser Emamjomeh-Kashan
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Survival ◽  
Ram Lambs

scholarly journals Human Testis Extracellular Matrix Enhances Human Spermatogonial Stem Cell Survival In Vitro

2019 ◽  
Vol 25 (7-8) ◽  
pp. 663-676 ◽  
Author(s):  
Mark H. Murdock ◽  
Sherin David ◽  
Ilea T. Swinehart ◽  
Janet E. Reing ◽  
Kien Tran ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Human Testis ◽  
Stem Cell Survival

The enhancement of neural stem cell survival and growth by coculturing with expanded sertoli cells in vitro

2011 ◽  
Vol 28 (1) ◽  
pp. 196-205 ◽  
Author(s):  
Bingyang Shi ◽  
Lei Deng ◽  
Xiaolin Shi ◽  
Sheng Dai ◽  
Hu Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Neural Stem Cell ◽  
Sertoli Cells ◽  
Stem Cell Survival ◽  
Survival And Growth

Adult Stem Cell Survival Strategies

2012 ◽  
pp. 383-404 ◽  
Author(s):  
Melanie Rodrigues ◽  
Linda Griffith ◽  
Alan Wells
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Adult Stem Cell ◽  
Survival Strategies ◽  
Stem Cell Survival

Prosurvival and antiapoptotic effects of PGE2in radiation injury are mediated by EP2 receptor in intestine

2003 ◽  
Vol 284 (3) ◽  
pp. G490-G498 ◽  
Author(s):  
Courtney W. Houchen ◽  
Mark A. Sturmoski ◽  
Shrikant Anant ◽  
Richard M. Breyer ◽  
William F. Stenson
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Cross Section ◽  
Radiation Injury ◽  
Biological Activities ◽  
Receptor Expression ◽  
Apoptotic Cells ◽  
Wild Type ◽  
Γ Irradiation ◽  
Stem Cell Survival

The biological activities of PGE2 are mediated through EP receptors (EP1–EP4), plasma membrane G protein-coupled receptors that differ in ligand binding and signal-transduction pathways. We investigated gastrointestinal EP2 receptor expression in adult mice before and after radiation injury and evaluated intestinal stem cell survival and crypt epithelial apoptosis after radiation injury in EP2 null mice. EP2 was expressed throughout the gut. Intestinal EP2 mRNA increased fivefold after γ-irradiation. Crypt survival was diminished in EP2 −/− mice (4.06 crypts/cross section) compared with wild-type littermates (8.15 crypts/cross section). Radiation-induced apoptosis was significantly increased in EP2 −/− mice compared with wild-type littermates. Apoptosis was 1.6-fold higher in EP2 −/− mice (5.9 apoptotic cells/crypt) than in wild-type mice (3.5 apoptotic cells/crypt). The EP2receptor is expressed in mouse gastrointestinal epithelial cells and is upregulated following radiation injury. The effects of PGE2on both crypt epithelial apoptosis and intestinal crypt stem cell survival are mediated through the EP2 receptor.

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