Towards new therapeutic approaches for malignant melanoma

2011 ◽  
Vol 13 ◽  
Author(s):  
Ivan Pacheco ◽  
Cristina Buzea ◽  
Victor Tron
Keyword(s):  
Molecular Mechanisms ◽  
Acquired Resistance ◽  
Therapeutic Approaches ◽  
Term Survival ◽  
Therapeutic Modalities ◽  
New Therapeutic Approaches ◽  
Mirna Genes ◽  
Molecular Therapeutics ◽  
Multistep Process

Recent progress in understanding the molecular mechanisms of the initiation and progression of melanoma has created new opportunities for developing novel therapeutic modalities to manage this potentially lethal disease. Although at first glance, melanoma carcinogenesis appears to be a chaotic system, it is indeed, arguably, a deterministic multistep process involving sequential alterations of proto-oncogenes, tumour suppressors and miRNA genes. The scope of this article is to discuss the most recent and significant advances in melanoma molecular therapeutics. It is apparent that using single agents targeting solely individual melanoma pathways might be insufficient for long-term survival. However, the outstanding results on melanoma survival observed with novel selective inhibitors of B-RAF, such as PLX4032 give hope that melanoma can be cured. The fact that melanoma develops acquired resistance to PLX4032 emphasises the importance of simultaneously targeting several pathways. Because the most striking feature of melanoma is its unsurpassed ability to metastasise, it is important to implement newer systems for drug delivery adapted from research on stem cells and nanotechnology.

Memory Reconsolidation as a Common Change Process

2020 ◽  
pp. 328-360
Author(s):  
Rhonda Goldman ◽  
Alyssa Fredrick-Keniston
Keyword(s):  
Change Process ◽  
Memory Model ◽  
Memory Reconsolidation ◽  
Future Research ◽  
Therapeutic Approaches ◽  
Therapeutic Modalities ◽  
Change Mechanisms ◽  
Definition Of ◽  
Constituent Elements

Memory reconsolidation is considered as a common change process that exists across the major individual therapeutic modalities that are aimed at promoting and sustaining long- term, enduring change. The integrative memory model is reviewed in terms of how it may provide the field of psychotherapy integration with a description of a process that all individual therapies seek to achieve. First, the change mechanisms underlying each of the major therapeutic approaches including behavioral, cognitive-behavioral, psychodynamic and emotion-focused therapies are examined to determine the degree to which they describe a memory reconsolidation process. Next, some of the newer, modern integrative therapeutic approaches are reviewed to consider whether they too are promoting a memory reconsolidation process, although not necessarily naming it as such. The memory reconsolidation model and its constituent elements are then examined in depth to determine the degree to which the various therapy models promote and encourage relative aspects of the memory reconsolidation process. Finally, a potentially clarifying definition of terms is proposed and future research is suggested that would help the field determine the degree to which memory reconsolidation is a common change process and if so, how it can best be promoted.

scholarly journals Neuroinflammatory Nexus of Pediatric Epilepsy

2018 ◽  
Vol 07 (02) ◽  
pp. 032-039
Author(s):  
Shruti Bagla ◽  
Alan Dombkowski
Keyword(s):  
Inflammatory Mediators ◽  
Molecular Mechanisms ◽  
Potential Role ◽  
Recent Literature ◽  
Refractory Epilepsy ◽  
Genetic Mutation ◽  
Pediatric Epilepsy ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches

AbstractA rapidly growing body of evidence supports the premise that neuroinflammation plays an important role in initiating and sustaining seizures in a range of pediatric epilepsies. Clinical and experimental evidence indicates that neuroinflammation is both an outcome and a contributor to seizures. In this manner, seizures that arise from an initial insult (e.g., infection, trauma, and genetic mutation) contribute to an inflammatory response that subsequently promotes recurrent seizures. This cyclic relationship between seizures and neuroinflammation has been described as a “vicious cycle.” Studies of human tissue resected for surgical treatment of refractory epilepsy have reported activated inflammatory and immune signaling pathways, while animal models have been used to demonstrate that key inflammatory mediators lead to increased seizure susceptibility. Further characterization of the molecular mechanisms involved in this cycle may ultimately enable the development of new therapeutic approaches for the treatment of epilepsy. In this brief review, we focus on key inflammatory mediators that have become prominent in recent literature of epilepsy, including newly characterized microRNAs and their potential role in neuroinflammatory signaling.

scholarly journals MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Romina Aron Badin ◽  
Aurore Bugi ◽  
Susannah Williams ◽  
Marta Vadori ◽  
Marie Michael ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Neurodegenerative Disorders ◽  
Therapeutic Approaches ◽  
Primate Model ◽  
Term Survival ◽  
Neural Grafts ◽  
Neuro Inflammation ◽  
Hla Haplotypes

Abstract Cell therapy products (CTP) derived from pluripotent stem cells (iPSCs) may constitute a renewable, specifically differentiated source of cells to potentially cure patients with neurodegenerative disorders. However, the immunogenicity of CTP remains a major issue for therapeutic approaches based on transplantation of non-autologous stem cell-derived neural grafts. Despite its considerable side-effects, long-term immunosuppression, appears indispensable to mitigate neuro-inflammation and prevent rejection of allogeneic CTP. Matching iPSC donors’ and patients’ HLA haplotypes has been proposed as a way to access CTP with enhanced immunological compatibility, ultimately reducing the need for immunosuppression. In the present work, we challenge this paradigm by grafting autologous, MHC-matched and mis-matched neuronal grafts in a primate model of Huntington’s disease. Unlike previous reports in unlesioned hosts, we show that in the absence of immunosuppression MHC matching alone is insufficient to grant long-term survival of neuronal grafts in the lesioned brain.

scholarly journals Global View of Candidate Therapeutic Target Genes in Hormone-Responsive Breast Cancer

2020 ◽  
Vol 21 (11) ◽  
pp. 4068 ◽  
Author(s):  
Annamaria Salvati ◽  
Valerio Gigantino ◽  
Giovanni Nassa ◽  
Valeria Mirici Cappa ◽  
Giovanna Maria Ventola ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Target Genes ◽  
Acquired Resistance ◽  
Biological Significance ◽  
Response To Therapy ◽  
Term Survival ◽  
Tumor Spread ◽  
Long Term Survival

Breast cancer (BC) is a heterogeneous disease characterized by different biopathological features, differential response to therapy and substantial variability in long-term-survival. BC heterogeneity recapitulates genetic and epigenetic alterations affecting transformed cell behavior. The estrogen receptor alpha positive (ERα+) is the most common BC subtype, generally associated with a better prognosis and improved long-term survival, when compared to ERα-tumors. This is mainly due to the efficacy of endocrine therapy, that interfering with estrogen biosynthesis and actions blocks ER-mediated cell proliferation and tumor spread. Acquired resistance to endocrine therapy, however, represents a great challenge in the clinical management of ERα+ BC, causing tumor growth and recurrence irrespective of estrogen blockade. Improving overall survival in such cases requires new and effective anticancer drugs, allowing adjuvant treatments able to overcome resistance to first-line endocrine therapy. To date, several studies focus on the application of loss-of-function genome-wide screenings to identify key (hub) “fitness” genes essential for BC progression and representing candidate drug targets to overcome lack of response, or acquired resistance, to current therapies. Here, we review the biological significance of essential genes and relative functional pathways affected in ERα+ BC, most of which are strictly interconnected with each other and represent potential effective targets for novel molecular therapies.

Sex Therapy

1991 ◽  
Vol 19 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Keith Hawton
Keyword(s):  
Cognitive Processes ◽  
Sex Therapy ◽  
Therapeutic Interventions ◽  
Long Term Results ◽  
Weekly Schedule ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Low Sexual Desire ◽  
Methods Of Treatment

The introduction of sex therapy two decades ago was accompanied by largely uncritical enthusiasm, with the result that too few careful evaluative studies were conducted. Those that were indicated that a weekly or twice weekly schedule of treatment sessions was best and that treatment by individual therapists was as effective as co-therapy. Some of the major prognostic factors and the long-term results of sex therapy have now been elucidated. Low sexual desire has emerged as a problem for which our now traditional methods of treatment are often inadequate and new therapeutic approaches are required. Current efforts to explore the beliefs and cognitive processes associated with erectile dysfunction are proving rewarding and are likely to enrich therapeutic interventions in the future. Attention should now be paid to the beliefs and cognitions associated with other sexual dysfunctions, both male and female.

scholarly journals Non-Coding RNAs and Wnt/β-Catenin Signaling Pathway in Gastric Cancer: From EMT to Drug Resistance

Onco ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 140-157
Author(s):  
Bruno Takao Real Karia ◽  
Camila Albuquerque Pinto ◽  
Carolina Oliveira Gigek ◽  
Fernanda Wisnieski ◽  
Marilia Arruda Cardoso Smith
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Biological Processes ◽  
Therapeutic Approaches ◽  
Term Survival ◽  
The Third ◽  
The Past ◽  
Sequencing Technologies ◽  
Non Coding Rnas

Gastric cancer is one of the most common cancers and the third cause of cancer-related death worldwide. The treatment of GC patients improved due to advancements in surgery, radiotherapy and chemotherapy. However, the long-term survival rate of patients with gastric cancer remains around 20%. Thus, development of novel therapeutic approaches is of great interest, in order to reduce the need for mutilating surgeries and morbid adjuvant therapies. For many years, it was believed that the RNA was a mere intermediate molecule in the genetic information flow. However, during the past decades, with the advent of new sequencing technologies, it was revealed that non-coding RNAs play important roles in many different biological processes. The Wnt/β-catenin signaling pathway has been reported to regulate crucial events during neoplasic development, such as cell differentiation, proliferation, invasion, migration, apoptosis, and angiogenesis. In this review, we will focus on microRNAs and long non-coding RNAs that have been implicated in gastric cancer tumorigenesis via modulation of the Wnt/β-catenin signaling pathway, which provided some biomarkers to prognosis, diagnosis, and therapy.

scholarly journals New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2149
Author(s):  
Juan L. Paris ◽  
Paz de la Torre ◽  
Ana I. Flores
Keyword(s):  
Cell Therapy ◽  
Treatment Options ◽  
Allergic Diseases ◽  
Immunological Tolerance ◽  
Term Treatment ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Long Term Treatment ◽  
Nano Material

Allergy constitutes a major health issue due to its large prevalence. The established therapeutic approaches (allergen avoidance, antihistamines, and corticosteroids) do not address the underlying causes of the pathology, highlighting the need for other long-term treatment options. Antigen-specific immunotherapy enables the long-term control of allergic diseases by promoting immunological tolerance to the allergen. However, efficacious immunotherapies are not available for all possible allergens, and the risk of undesired reactions during therapy remains a concern, especially in patients with severe allergic reactions. In this context, two types of therapeutic strategies appear especially promising for the future in the context of allergy: cell therapy and bio- or nano-material-based therapy. In this review, the main strategies developed this far in these two types of strategies are discussed, with several examples illustrating the different approaches.

scholarly journals An Overview of Long Non-Coding (lnc)RNAs in Neuroblastoma

2021 ◽  
Vol 22 (8) ◽  
pp. 4234
Author(s):  
Francesca Baldini ◽  
Matilde Calderoni ◽  
Laura Vergani ◽  
Paola Modesto ◽  
Tullio Florio ◽  
...  
Keyword(s):  
Recent Progress ◽  
Molecular Mechanisms ◽  
Mechanisms Of Action ◽  
Biological Functions ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Definitive Therapy ◽  
Sporadic Cases ◽  
Non Coding Rnas

Neuroblastoma (NB) is a heterogeneous developmental tumor occurring in childhood, which arises from the embryonic sympathoadrenal cells of the neural crest. Although the recent progress that has been done on this tumor, the mechanisms involved in NB are still partially unknown. Despite some genetic aberrations having been identified, the sporadic cases represent the majority. Due to its wide heterogeneity in clinical behavior and etiology, NB represents a challenge in terms of prevention and treatment. Since a definitive therapy is lacking so far, there is an urgent necessity to unveil the molecular mechanisms behind NB onset and progression to develop new therapeutic approaches. Long non-coding RNAs (lncRNAs) are a group of RNAs longer than 200 nucleotides. Whether lncRNAs are destined to become a protein or not, they exert multiple biological functions such as regulating gene expression and functions. In recent decades, different research has highlighted the possible role of lncRNAs in the pathogenesis of many diseases, including cancer. Moreover, lncRNAs may represent potential markers or targets for diagnosis and treatment of diseases. This mini-review aimed to briefly summarize the most recent findings on the involvement of some lncRNAs in NB disease by focusing on their mechanisms of action and possible role in unveiling NB onset and progression.

scholarly journals Tackling Chronic Kidney Transplant Rejection: Challenges and Promises

2021 ◽  
Vol 12 ◽  
Author(s):  
Xingqiang Lai ◽  
Xin Zheng ◽  
James M. Mathew ◽  
Lorenzo Gallon ◽  
Joseph R. Leventhal ◽  
...  
Keyword(s):  
Early Detection ◽  
Kidney Transplant ◽  
Molecular Mechanisms ◽  
Rapid Development ◽  
Transplant Rejection ◽  
Great Promise ◽  
Term Survival ◽  
Antibody Mediated Rejection ◽  
Novel Therapeutic

Despite advances in post-transplant management, the long-term survival rate of kidney grafts and patients has not improved as approximately forty percent of transplants fails within ten years after transplantation. Both immunologic and non-immunologic factors contribute to late allograft loss. Chronic kidney transplant rejection (CKTR) is often clinically silent yet progressive allogeneic immune process that leads to cumulative graft injury, deterioration of graft function. Chronic active T cell mediated rejection (TCMR) and chronic active antibody-mediated rejection (ABMR) are classified as two principal subtypes of CKTR. While significant improvements have been made towards a better understanding of cellular and molecular mechanisms and diagnostic classifications of CKTR, lack of early detection, differential diagnosis and effective therapies continue to pose major challenges for long-term management. Recent development of high throughput cellular and molecular biotechnologies has allowed rapid development of new biomarkers associated with chronic renal injury, which not only provide insight into pathogenesis of chronic rejection but also allow for early detection. In parallel, several novel therapeutic strategies have emerged which may hold great promise for improvement of long-term graft and patient survival. With a brief overview of current understanding of pathogenesis, standard diagnosis and challenges in the context of CKTR, this mini-review aims to provide updates and insights into the latest development of promising novel biomarkers for diagnosis and novel therapeutic interventions to prevent and treat CKTR.

Sign in / Sign up

Export Citation Format

Share Document