Strategies to Control or Mimic Growth Factor Activity for Bone, Cartilage, and Osteochondral Tissue Engineering

Author(s):  
Kelly B. Seims ◽  
Natasha K. Hunt ◽  
Lesley W. Chow
2009 ◽  
Vol 134 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Xiaoqin Wang ◽  
Esther Wenk ◽  
Xiaohui Zhang ◽  
Lorenz Meinel ◽  
Gordana Vunjak-Novakovic ◽  
...  

2013 ◽  
Vol 587 ◽  
pp. 245-248 ◽  
Author(s):  
Le Ping Yan ◽  
Joaquim Miguel Oliveira ◽  
Ana L. Oliveira ◽  
Rui L. Reis

In this study, bilayered silk and silk/nanoCaP scaffolds were developed for osteochondral tissue engineering. Aqueous silk solution (16 wt.%) was used for preparation of the cartilage-like layer and, for generation of the silk/nanoCaP suspension and the bottom layer (CaP/Silk: 16 wt.%). The scaffolds were formed by using salt-leaching/lyophilization approach. The scanning electron microscopy revealed that the both layers presented porous structure and integrated well. Micro-computed tomography images confirmed that the CaP phase was only retained in the silk/nanoCaP layer. The hydration degree and mechanical properties of the bilayered scaffold were comparable to the ones of each single layer. The apatite crystal formation was limited to the silk/nanoCaP layer, when soaking the scaffold in a simulated body fluid solution, which is a must for the application of the developed scaffolds in OC tissue engineering.


Author(s):  
Trachtenberg Jordan ◽  
Placone Jesse ◽  
Smith Brandon ◽  
Piard Charlotte ◽  
Fisher John ◽  
...  

Author(s):  
Eleonora Pintus ◽  
Matteo Baldassarri ◽  
Luca Perazzo ◽  
Simone Natali ◽  
Diego Ghinelli ◽  
...  

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