Transition-Metal-Free Three-Component Reaction: Additive Controlled Synthesis of Sulfonylated Imidazoles

A novel transition-metal-free cleavage of C–C double bonds has been developed from a three-component reaction involving aromatic alkenes, S8and amides, generating various aryl thioamides in up to 96% yields.

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Transition-metal-free three-component reaction of cyclopropenes, aldehydes and amines

Chemical Communications ◽

10.1039/c6cc06743c ◽

2016 ◽

Vol 52 (90) ◽

pp. 13285-13287 ◽

Cited By ~ 6

Author(s):

Hang Zhang ◽

Bo Wang ◽

Heng Yi ◽

Tong Sun ◽

Yan Zhang ◽

...

Keyword(s):

Transition Metal ◽

Ring Opening ◽

Metal Free ◽

Three Component Reaction ◽

Electron Withdrawing Substituents

A formal [3+2] cycloaddition triggered by enamine-mediated ring-opening of cyclopropenes bearing electron-withdrawing substituents is presented.

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Direct synthesis of ortho-methylthio allyl and vinyl ethers via three component reaction of aryne, activated alkene and DMSO

Organic & Biomolecular Chemistry ◽

10.1039/d0ob00275e ◽

2020 ◽

Vol 18 (14) ◽

pp. 2727-2738 ◽

Cited By ~ 3

Author(s):

Hemanta Hazarika ◽

Pranjal Gogoi

Keyword(s):

Transition Metal ◽

Direct Synthesis ◽

Vinyl Ethers ◽

Metal Free ◽

Synthetic Strategy ◽

Three Component Reaction ◽

Three Component Coupling

A transition-metal free synthetic strategy for the direct synthesis of ortho-methylthio allyl and vinyl ethers via cascade three-component coupling of aryne, activated alkene and DMSO.

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Transition‐Metal‐Free Synthesis of Unsymmetrical Disulfides via Three‐Component Reaction of Thiosulfonates, Thiourea and Alkyl halides

Advanced Synthesis & Catalysis ◽

10.1002/adsc.202100165 ◽

2021 ◽

Author(s):

Dungai Wang ◽

Quan He ◽

Keqiang Shi ◽

Mingteng Xiong ◽

Yi-Feng Zhou ◽

...

Keyword(s):

Transition Metal ◽

Alkyl Halides ◽

Metal Free ◽

Three Component Reaction

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Base-Catalyzed Tandem Cyclization: Diastereoselective Access to the 3,4-Dihydroisoquinolin-2(1H)-one Core

Synthesis ◽

10.1055/s-0037-1610999 ◽

2018 ◽

Vol 51 (06) ◽

pp. 1473-1481 ◽

Cited By ~ 4

Author(s):

Harshadas Meshram ◽

Ravindra Kumbhare ◽

Prashishkumar Shirsat ◽

Navnath Khomane ◽

Sneha Meshram ◽

...

Keyword(s):

Natural Products ◽

Transition Metal ◽

Acetylenic Esters ◽

One Pot ◽

Direct Construction ◽

Metal Free ◽

Diastereoselective Reaction ◽

Three Component Reaction ◽

Tandem Cyclization

A novel, one-pot reaction for the synthesis of 3,4-dihydroisoquinolin-2(1H)-one derivatives is developed via a base-mediated three-component reaction of ninhydrin, aniline and acetylenic esters. This diastereoselective reaction takes place in methanol at 70 °C under transition-metal-free conditions, and direct construction of the C–N and C–C bonds is readily achieved via tandem cyclization. These cyclic frameworks are resourceful small molecular keys to many natural products.

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