Self-Assembly, Drug Encapsulation, and Cellular Uptake of Block and Gradient Copolymers of 2-Methyl-2-oxazine and 2-n-Propyl/butyl-2-oxazoline

2021 ◽  
Author(s):  
David Babuka ◽  
Kristyna Kolouchova ◽  
Lenka Loukotova ◽  
Ondrej Sedlacek ◽  
Ondrej Groborz ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Self Assembly ◽  
Drug Encapsulation ◽  
Gradient Copolymers

scholarly journals Self-Assembly of Hydrogen-Bonding Gradient Copolymers: Sequence Control via Tandem Living Radical Polymerization with Transesterification

2017 ◽  
Vol 50 (8) ◽  
pp. 3215-3223 ◽  
Author(s):  
Yusuke Ogura ◽  
Müge Artar ◽  
Anja R. A. Palmans ◽  
Mitsuo Sawamoto ◽  
E. W. Meijer ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Radical Polymerization ◽  
Self Assembly ◽  
Living Radical Polymerization ◽  
Gradient Copolymers

scholarly journals Effect of the Hydrophilic-Hydrophobic Balance of Antigen-Loaded Peptide Nanofibers on Their Cellular Uptake, Cellular Toxicity, and Immune Stimulatory Properties

2019 ◽  
Vol 20 (15) ◽  
pp. 3781 ◽  
Author(s):  
Tomonori Waku ◽  
Saki Nishigaki ◽  
Yuichi Kitagawa ◽  
Sayaka Koeda ◽  
Kazufumi Kawabata ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Self Assembly ◽  
Sheet Forming ◽  
Design Guidelines ◽  
Cellular Interactions ◽  
Antigenic Peptides ◽  
Peptide Nanofibers ◽  
Dc Line ◽  
Chain Lengths ◽  
Β Sheet

Recently, nanofibers (NFs) formed from antigenic peptides conjugated to β-sheet-forming peptides have attracted much attention as a new generation of vaccines. However, studies describing how the hydrophilic-hydrophobic balance of NF components affects cellular interactions of NFs are limited. In this report, three different NFs were prepared by self-assembly of β-sheet-forming peptides conjugated with model antigenic peptides (SIINFEKL) from ovalbumin and hydrophilic oligo-ethylene glycol (EG) of differing chain lengths (6-, 12- and 24-mer) to investigate the effect of EG length of antigen-loaded NFs on their cellular uptake, cytotoxicity, and dendritic cell (DC)-stimulation ability. We used an immortal DC line, termed JAWS II, derived from bone marrow-derived DCs of a C57BL/6 p53-knockout mouse. The uptake of NFs, consisting of the EG 12-mer by DCs, was the most effective and activated DC without exhibiting significant cytotoxicity. Increasing the EG chain length significantly reduced cellular entry and DC activation by NFs. Conversely, shortening the EG chain enhanced DC activation but increased toxicity and impaired water-dispersibility, resulting in low cellular uptake. These results show that the interaction of antigen-loaded NFs with cells can be tuned by the EG length, which provides useful design guidelines for the development of effective NF-based vaccines.

Synthesis of CO2-responsive gradient copolymers by switchable RAFT polymerization and their controlled self-assembly

2020 ◽  
Vol 11 (42) ◽  
pp. 6794-6802
Author(s):  
Xiaofeng Guo ◽  
Tianren Zhang ◽  
Yuetong Wu ◽  
Wencheng Shi ◽  
Bonnie Choi ◽  
...  
Keyword(s):  
Self Assembly ◽  
Raft Polymerization ◽  
Good Control ◽  
Acid Base ◽  
Gradient Copolymers

Switchable RAFT agents, so-called because they can be reversibly switched by an acid/base stimulus to offer very good control over polymerization of both MAMs and LAMs, provide a route to prepare well-defined polyMAM-block-polyLAM copolymers.

Monocomponent hexa- and dodecaethylene glycol succinyl-tocopherol esters: Self-assembly structures, cellular uptake and sensitivity to enzyme hydrolysis

2009 ◽  
Vol 78 (12) ◽  
pp. 1464-1474 ◽  
Author(s):  
Britta M. Folmer ◽  
Denis Barron ◽  
Eric Hughes ◽  
Laurence Miguet ◽  
Belén Sanchez ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Self Assembly ◽  
Enzyme Hydrolysis ◽  
Dodecaethylene Glycol

scholarly journals Taurine Boosts Cellular Uptake of Smalld-Peptides for Enzyme-Instructed Intracellular Molecular Self-Assembly

2015 ◽  
Vol 137 (32) ◽  
pp. 10040-10043 ◽  
Author(s):  
Jie Zhou ◽  
Xuewen Du ◽  
Jie Li ◽  
Natsuko Yamagata ◽  
Bing Xu
Keyword(s):  
Cellular Uptake ◽  
Self Assembly

Design and Biocatalytic Synthesis of Pluronics-based Nanomicellar Self-assembly Systems for Drug Encapsulation Applications

2010 ◽  
Vol 47 (8) ◽  
pp. 788-793 ◽  
Author(s):  
Mukesh K. Pandey ◽  
Ke Yang ◽  
Cao Pei ◽  
Pramod K. Sharma ◽  
Joana Viola ◽  
...  
Keyword(s):  
Self Assembly ◽  
Assembly Systems ◽  
Drug Encapsulation

Gradient helical copolymers: synthesis, chiroptical properties, thermotropic liquid crystallinity, and self-assembly in selective organic solvents

2018 ◽  
Vol 9 (15) ◽  
pp. 2002-2010 ◽  
Author(s):  
Junxian Chen ◽  
Bowen Li ◽  
Xiaofu Li ◽  
Jie Zhang ◽  
Xinhua Wan
Keyword(s):  
Organic Solvents ◽  
Self Assembly ◽  
Radical Copolymerization ◽  
Atom Transfer ◽  
Liquid Crystallinity ◽  
Gradient Copolymers ◽  
Chiroptical Properties

A series of novel gradient copolymers R-(−)-poly(StN-grad-C8) were synthesized through atom transfer radical copolymerization of an achiral styrenic monomer, N,N-dimethyl-4-ethenylbenzamide (M-StN), and a chiral bulky vinylterphenyl monomer, (−)-2,5-bis{4′-[(R)-sec-octyloxycarbonyl]phenyl}styrene (R-(−)-M-C8).

Unusual self-assembly of a hydrophilic β-cyclodextrin inclusion complex into vesicles capable of drug encapsulation and release

2015 ◽  
Vol 3 (17) ◽  
pp. 3425-3428 ◽  
Author(s):  
Nagaraj Nayak ◽  
Karical R. Gopidas
Keyword(s):  
Inclusion Complex ◽  
Self Assembly ◽  
Cancer Drug ◽  
Drug Encapsulation ◽  
Cyclodextrin Inclusion ◽  
Anti Cancer ◽  
Cyclodextrin Inclusion Complex ◽  
Complex Forms

A hydrophilic β-cyclodextrin bis-inclusion complex forms supramolecular vesicles which can be loaded with the anti-cancer drug doxorubicin. The loaded drug can be released upon addition of a competitive inclusion binder such as adamantane carboxylate.

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