Bone-Targeting Polymer Vesicles for Effective Therapy of Osteoporosis

Nano Letters ◽  
2021 ◽  
Vol 21 (19) ◽  
pp. 7998-8007
Author(s):  
Xue Zhou ◽  
Erik Jan Cornel ◽  
Zhen Fan ◽  
Shisheng He ◽  
Jianzhong Du
Keyword(s):  
Effective Therapy ◽  
Polymer Vesicles ◽  
Bone Targeting

Bone-targeting polymer vesicles for simultaneous imaging and effective malignant bone tumor treatment

Biomaterials ◽  
2020 ◽  
pp. 120345
Author(s):  
Xue Zhou ◽  
Ning Yan ◽  
Erik J. Cornel ◽  
Haidong Cai ◽  
Shaobo Xue ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Malignant Bone Tumor ◽  
Tumor Treatment ◽  
Simultaneous Imaging ◽  
Polymer Vesicles ◽  
Bone Targeting

Ultrastructural features of prognostic significance in human oral cancer

1992 ◽  
Vol 50 (1) ◽  
pp. 618-619
Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma
Keyword(s):  
Oral Cancer ◽  
Squamous Cell ◽  
Common Knowledge ◽  
Prognostic Significance ◽  
Growth Control ◽  
Terminal Differentiation ◽  
Squamous Cell Carcinomas ◽  
Effective Therapy ◽  
Invasive Potential ◽  
Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

Diagnostic confusion in paediatric respiratory pathology. Case report

ORL ro ◽  
2016 ◽  
Vol 1 (1) ◽  
pp. 48-50
Author(s):  
Adina A. Zamfir-Chiru-Anton ◽  
D.C. Gheorghe
Keyword(s):  
Case Report ◽  
Foreign Body ◽  
Clinical Picture ◽  
Foreign Body Aspiration ◽  
Effective Therapy ◽  
Partial Loss ◽  
Detailed History ◽  
Therapy Approach ◽  
Diagnostic Confusion ◽  
Respiratory Pathology

The authors present the case of a 4-year-old child admitted to the ENT Department with possible pulmonary foreign body aspiration. A detailed history revealed a clinical picture that seemed to depict an absence episode (with partial loss of conscience and cianosis) occured when eating, less the symptomes of a respiratory foreign body. Diagnosis needed full respiratory endoscopy and neurologic evaluation for correct assesment and effective therapy approach.

Flow Chemistry Controls Both Self-Assembly and the Entrapped Oscillatory Cargo in Belousov-Zhabotinsky Driven Polymerization-Induced Self-Assembly

2019 ◽  
Author(s):  
Liman Hou ◽  
Marta Dueñas-Diez ◽  
Rohit Srivastava ◽  
Juan Perez-Mercader
Keyword(s):  
Self Assembly ◽  
Flow Chemistry ◽  
Batch Reactors ◽  
Equilibrium Conditions ◽  
One Pot ◽  
Bz Reaction ◽  
Polymer Vesicles ◽  
Simultaneous Control ◽  
Novel Method ◽  
Continuously Stirred Tank Reactor

<p></p><p>Belousov-Zhabotinsky (B-Z) reaction driven polymerization-induced self-assembly (PISA), or B-Z PISA, is a novel method for the autonomous one-pot synthesis of polymer vesicles from a macroCTA (macro chain transfer agent) and monomer solution (“soup”) containing the above and the BZ reaction components. In it, the polymerization is driven (and controlled) by periodically generated radicals generated in the oscillations of the B-Z reaction. These are inhibitor/activator radicals for the polymerization. Until now B-Z PISA has only been carried out in batch reactors. In this manuscript we present the results of running the system using a continuously stirred tank reactor (CSTR) configuration which offers some interesting advantages.Indeed, by controlling the CSTR parameters we achieve reproducible and simultaneous control of the PISA process and of the properties of the oscillatory cargo encapsulated in the resulting vesicles. Furthermore, the use of flow chemistry enables a more precise morphology control and chemical cargo tuning. Finally, in the context of biomimetic applications a CSTR operation mimics more closely the open non-equilibrium conditions of living systems and their surrounding environments.</p><p></p>

EFFECTIVE THERAPY OF ENDOMETRITIS OF SWEETS

2018 ◽  
Vol 236 (4) ◽  
pp. 5-9
Author(s):  
Abramov S.V Abramov ◽  
◽  
Kashkovskaya L.M. Kashkovskaya ◽  
Safarova M.I. Safarova ◽  
◽  
...  
Keyword(s):  
Effective Therapy
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