Moist-Retaining, Self-Recoverable, Bioadhesive, and Transparent in Situ Forming Hydrogels To Accelerate Wound Healing

2020 ◽  
Vol 12 (2) ◽  
pp. 2023-2038 ◽  
Author(s):  
Jun Li ◽  
Fan Yu ◽  
Gong Chen ◽  
Jia Liu ◽  
Xiao-Long Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Accelerate Wound Healing ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

scholarly journals In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

2019 ◽  
Vol 10 (4) ◽  
pp. 50 ◽  
Author(s):  
Federica Leone ◽  
Melike Firlak ◽  
Kirsty Challen ◽  
Wayne Bonnefin ◽  
Barbara Onida ◽  
...  
Keyword(s):  
Wound Healing ◽  
In Vitro Release ◽  
Patient Specific ◽  
Hacat Cells ◽  
In Situ Gel ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels ◽  
In Situ Crosslinking

In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing.

scholarly journals Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

2020 ◽  
Author(s):  
Isabel Pereira ◽  
José Eduardo Pereira ◽  
Luís Maltez ◽  
Alexandra Rodrigues ◽  
Catarina Rodrigues ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Substitute ◽  
Bone Substitutes ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Micro Computed Tomography ◽  
Synthetic Bone Substitute ◽  
In Situ Forming ◽  
Bioactive Agents ◽  
In Situ Forming Hydrogels

Abstract The development of injectable bone substitutes (IBS) have obtained great importance in the bone regeneration field, as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies. In this scenario, the association of injectable hydrogels and bone graft granules is emerging as a well-established trend. Particularly, in situ forming hydrogels have arisen as a new IBS generation. An in situ forming and injectable dextrin-based hydrogel (HG) was developed, aiming to act as a carrier of granular bone substitutes and bioactive agents. In this work, the HG was associated to a granular bone substitute (Bonelike®) and implanted in goat critical-sized calvarial defects (14 mm) for 3, 6 and 12 weeks. The results showed that HG improved the handling properties of the Bonelike® granules and did not affect its osteoconductive features, neither impairing the bone regeneration process. Human multipotent mesenchymal stromal cells from the umbilical cord, extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the IBS. These bioactive agents did not enhance the new bone formation significantly under the conditions tested, according to micro-computed tomography and histological analysis.

Catechol-modified hyaluronic acid: in situ-forming hydrogels by auto-oxidation of catechol or photo-oxidation using visible light

2017 ◽  
Vol 74 (10) ◽  
pp. 4069-4085 ◽  
Author(s):  
Takeshi Sato ◽  
Takao Aoyagi ◽  
Mitsuhiro Ebara ◽  
Rachel Auzély-Velty
Keyword(s):  
Hyaluronic Acid ◽  
Visible Light ◽  
Photo Oxidation ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

In situ forming hydrogels of hyaluronic acid and inulin derivatives for cartilage regeneration

2015 ◽  
Vol 122 ◽  
pp. 408-416 ◽  
Author(s):  
Fabio S. Palumbo ◽  
Calogero Fiorica ◽  
Mauro Di Stefano ◽  
Giovanna Pitarresi ◽  
Alessandro Gulino ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cartilage Regeneration ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

Simultaneous Orthogonal Dual-Click Approach to Tough, in-Situ-Forming Hydrogels for Cell Encapsulation

2015 ◽  
Vol 137 (4) ◽  
pp. 1618-1622 ◽  
Author(s):  
Vinh X. Truong ◽  
Matthew P. Ablett ◽  
Stephen M. Richardson ◽  
Judith A. Hoyland ◽  
Andrew P. Dove
Keyword(s):  
Cell Encapsulation ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

In situ forming hydrogels with long-lasting miR-21 enhances the therapeutic potential of MSC by sustaining stimulation of target gene

2017 ◽  
Vol 28 (15) ◽  
pp. 1639-1650 ◽  
Author(s):  
Xianwei Zhang ◽  
Yufa Sun ◽  
Jianfeng Liu ◽  
Zhiyong Yi ◽  
Feng Gao ◽  
...  
Keyword(s):  
Target Gene ◽  
Therapeutic Potential ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels ◽  
Stimulation Of

Introduction to In Situ Forming Hydrogels for Biomedical Applications

2014 ◽  
pp. 5-35 ◽  
Author(s):  
Bogyu Choi ◽  
Xian Jun Loh ◽  
Aloysius Tan ◽  
Chun Keat Loh ◽  
Enyi Ye ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels
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