scholarly journals Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron

2022 ◽  
Author(s):  
Gosia M. Murawska ◽  
Caspar Vogel ◽  
Max Jan ◽  
Xinyan Lu ◽  
Matthias Schild ◽  
...  
Keyword(s):  
Methyl Transferase ◽  
Damage Repair ◽  
Repair Protein

scholarly journals Antiparallel Coiled-Coil Interactions Mediate the Homodimerization of the DNA Damage-Repair Protein PALB2

Biochemistry ◽  
2018 ◽  
Vol 57 (47) ◽  
pp. 6581-6591 ◽  
Author(s):  
Fei Song ◽  
Minxing Li ◽  
Gaohua Liu ◽  
G.V.T. Swapna ◽  
Nourhan S. Daigham ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Repair ◽  
Coiled Coil ◽  
Damage Repair ◽  
Repair Protein ◽  
Antiparallel Coiled Coil

The DNA damage repair protein Ku70 regulates tumor cell and hepatic carcinogenesis by interacting with FOXO4

2016 ◽  
Vol 212 (3) ◽  
pp. 153-161 ◽  
Author(s):  
Tingting Zhang ◽  
Xiubing Zhang ◽  
Weidong Shi ◽  
Jian Xu ◽  
Hui Fan ◽  
...  
Keyword(s):  
Dna Damage ◽  
Tumor Cell ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Repair Protein ◽  
Hepatic Carcinogenesis

scholarly journals The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression

2017 ◽  
Vol 39 ◽  
pp. 18-31 ◽  
Author(s):  
Somsubhra Nath ◽  
Shrabasti Roychoudhury ◽  
Matthew J. Kling ◽  
Heyu Song ◽  
Pranjal Biswas ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Repair Protein

scholarly journals ATM controls DNA repair and mitochondria transfer between neighboring cells

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Sha Jin ◽  
Nils Cordes
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Dependent Manner ◽  
Intercellular Signaling ◽  
Tissue Integrity ◽  
Damage Repair ◽  
Repair Protein ◽  
Mitochondria Transfer ◽  
Dna Repair Protein ◽  
Direct Cell

Abstract Intercellular communication is essential for multicellular tissue vitality and homeostasis. We show that healthy cells message protective signals through direct cell–cell connections to adjacent DNA–damaged cells in a microtubule–dependent manner. In DNA–damaged cells, mitochondria restoration is facilitated by fusion with undamaged mitochondria from healthy cells and their DNA damage repair is optimized in presence of healthy cells. Both, mitochondria transfer and intercellular signaling for an enhanced DNA damage response are critically regulated by the activity of the DNA repair protein ataxia telangiectasia mutated (ATM). These healthy–to–damaged prosurvival processes sustain normal tissue integrity and may be exploitable for overcoming resistance to therapy in diseases such as cancer.

scholarly journals SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18

2019 ◽  
Vol 18 (7) ◽  
pp. 1428-1436 ◽  
Author(s):  
Manal Alsulami ◽  
Nayla Munawar ◽  
Eugene Dillon ◽  
Giorgio Oliviero ◽  
Kieran Wynne ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Repair Protein

scholarly journals Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology

2017 ◽  
Vol 114 (35) ◽  
pp. E7245-E7254 ◽  
Author(s):  
Shuai Zhao ◽  
Mo Yang ◽  
Wenfei Zhou ◽  
Baichao Zhang ◽  
Zhiqiang Cheng ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
High Throughput ◽  
Plasmon Resonance ◽  
Surface Plasmon Resonance Imaging ◽  
Resonance Imaging ◽  
Dna Mismatch ◽  
Damage Repair ◽  
Capsella Rubella ◽  
Repair Protein

Chemical modifications on histones and DNA/RNA constitute a fundamental mechanism for epigenetic regulation. These modifications often function as docking marks to recruit or stabilize cognate “reader” proteins. So far, a platform for quantitative and high-throughput profiling of the epigenetic interactome is urgently needed but still lacking. Here, we report a 3D-carbene chip-based surface plasmon resonance imaging (SPRi) technology for this purpose. The 3D-carbene chip is suitable for immobilizing versatile biomolecules (e.g., peptides, antibody, DNA/RNA) and features low nonspecific binding, random yet function-retaining immobilization, and robustness for reuses. We systematically profiled binding kinetics of 1,000 histone “reader–mark” pairs on a single 3D-carbene chip and validated two recognition events by calorimetric and structural studies. Notably, a discovery on H3K4me3 recognition by the DNA mismatch repair protein MSH6 in Capsella rubella suggests a mechanism of H3K4me3-mediated DNA damage repair in plant.

Clinicopathological significance of KU70/KU80, a key DNA damage repair protein in breast cancer

2013 ◽  
Vol 139 (2) ◽  
pp. 301-310 ◽  
Author(s):  
Alaa T. Alshareeda ◽  
Ola H. Negm ◽  
Nada Albarakati ◽  
Andrew R. Green ◽  
Christopher Nolan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Repair Protein ◽  
Clinicopathological Significance

Isolation and functional characterization of DNA damage repair protein (DRT) from Lepidium latifolium L.

2014 ◽  
Vol 337 (5) ◽  
pp. 302-310 ◽  
Author(s):  
Vimlendu Bhushan Sinha ◽  
Atul Grover ◽  
Zakwan Ahmed ◽  
Veena Pande
Keyword(s):  
Dna Damage ◽  
Functional Characterization ◽  
Dna Damage Repair ◽  
Lepidium Latifolium ◽  
Damage Repair ◽  
Repair Protein

scholarly journals DNA Repair in Huntington’s Disease and Spinocerebellar Ataxias: Somatic Instability and Alternative Hypotheses

2021 ◽  
Vol 10 (1) ◽  
pp. 165-173 ◽  
Author(s):  
Tamara Maiuri ◽  
Claudia L.K. Hung ◽  
Celeste Suart ◽  
Nola Begeja ◽  
Carlos Barba-Bazan ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Mismatch Repair ◽  
Dna Damage Repair ◽  
Cross Link ◽  
Somatic Instability ◽  
Damage Repair ◽  
Repair Protein

The use of genome wide association studies (GWAS) in Huntington’s disease (HD) research, driven by unbiased human data analysis, has transformed the focus of new targets that could affect age at onset. While there is a significant depth of information on DNA damage repair, with many drugs and drug targets, most of this development has taken place in the context of cancer therapy. DNA damage repair in neurons does not rely on DNA replication correction mechanisms. However, there is a strong connection between DNA repair and neuronal metabolism, mediated by nucleotide salvaging and the poly ADP-ribose (PAR) response, and this connection has been implicated in other age-onset neurodegenerative diseases. Validation of leads including the mismatch repair protein MSH3, and interstrand cross-link repair protein FAN1, suggest the mechanism is driven by somatic CAG instability, which is supported by the protective effect of CAA substitutions in the CAG tract. We currently do not understand: how somatic instability is triggered; the state of DNA damage within expanding alleles in the brain; whether this damage induces mismatch repair and interstrand cross-link pathways; whether instability mediates toxicity, and how this relates to human ageing. We discuss DNA damage pathways uncovered by HD GWAS, known roles of other polyglutamine disease proteins in DNA damage repair, and a panel of hypotheses for pathogenic mechanisms.

scholarly journals Structure of a DNA-damage repair protein

2001 ◽  
Vol 2 ◽  
pp. spotlight-20010810-01
Author(s):  
David Bruce
Keyword(s):  
Dna Damage ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Repair Protein
Sign in / Sign up

Export Citation Format

Share Document