scholarly journals Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity

2020 ◽  
Vol 11 (10) ◽  
pp. 2017-2023 ◽  
Author(s):  
Junichiro Uda ◽  
Seiichi Kobashi ◽  
Sachiho Miyata ◽  
Naoki Ashizawa ◽  
Koji Matsumoto ◽  
...  
Keyword(s):  
Uric Acid ◽  
Phenol Derivative ◽  
Lowering Activity

scholarly journals Effects of epigallocatechin-3-gallate combined with ascorbic acid and glycerol on the stability and uric acid-lowering activity of epigallocatechin-3-gallate

2021 ◽  
Vol 59 (1) ◽  
pp. 157-166
Author(s):  
Qianjin Xie ◽  
Xiaqiang Cai ◽  
Xu Dong ◽  
Ying Wang ◽  
Minghui Sun ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Uric Acid ◽  
The Stability ◽  
Lowering Activity

Novel monocyclic amide-linked phenol derivatives without mitochondrial toxicity have potent uric acid-lowering activity

2021 ◽  
Vol 40 ◽  
pp. 127900
Author(s):  
Junichiro Uda ◽  
Seiichi Kobashi ◽  
Naoki Ashizawa ◽  
Koji Matsumoto ◽  
Takashi Iwanaga
Keyword(s):  
Uric Acid ◽  
Mitochondrial Toxicity ◽  
Phenol Derivatives ◽  
Lowering Activity

391 Uric acid blood levels are associated with clinical and echocardiographic parameters of chronic heart failure

2003 ◽  
Vol 2 (1) ◽  
pp. 79
Author(s):  
P PAVLIDIS ◽  
J PARISSIS ◽  
S ANTONOPOULOS ◽  
D POLLATOS ◽  
P KIRIAZOPOULOS ◽  
...  
Keyword(s):  
Heart Failure ◽  
Uric Acid ◽  
Chronic Heart Failure ◽  
Blood Levels ◽  
Echocardiographic Parameters

Serum uric acid and obesity in Hawaiians

JAMA ◽  
1966 ◽  
Vol 196 (4) ◽  
pp. 364-365 ◽  
Author(s):  
L. A. Healey
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid

Increased monocyte to HDL cholesterol ratio in vitamin B12 deficiency: is it related to cardiometabolic risk?

2020 ◽  
pp. 1-8
Author(s):  
Sanem Kayhan ◽  
Nazli Gulsoy Kirnap ◽  
Mercan Tastemur
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Uric Acid ◽  
Vitamin B12 ◽  
Cardiometabolic Risk ◽  
Vitamin B12 Deficiency ◽  
Left Ventricular ◽  
Cardiometabolic Risk Factors ◽  
B12 Deficiency ◽  
Deficiency Group

Abstract. Vitamin B12 deficiency may have indirect cardiovascular effects in addition to hematological and neuropsychiatric symptoms. It was shown that the monocyte count-to-high density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel cardiovascular marker. In this study, the aim was to evaluate whether MHR was high in patients with vitamin B12 deficiency and its relationship with cardiometabolic risk factors. The study included 128 patients diagnosed with vitamin B12 deficiency and 93 healthy controls. Patients with vitamin B12 deficiency had significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), MHR, C-reactive protein (CRP) and uric acid levels compared with the controls (median 139 vs 115 mmHg, p < 0.001; 80 vs 70 mmHg, p < 0.001; 14.2 vs 9.5, p < 0.001; 10.2 vs 4 mg/dl p < 0.001; 6.68 vs 4.8 mg/dl, p < 0.001 respectively). The prevalence of left ventricular hypertrophy was higher in vitamin B12 deficiency group (43.8%) than the control group (8.6%) (p < 0.001). In vitamin B12 deficiency group, a positive correlation was detected between MHR and SBP, CRP and uric acid (p < 0.001 r:0.34, p < 0.001 r:0.30, p < 0.001 r:0.5, respectively) and a significant negative correlation was detected between MHR and T-CHOL, LDL, HDL and B12 (p < 0.001 r: −0.39, p < 0.001 r: −0.34, p < 0.001 r: −0.57, p < 0.04 r: −0.17, respectively). MHR was high in vitamin B12 deficiency group, and correlated with the cardiometabolic risk factors in this group, which were SBP, CRP, uric acid and HDL. In conclusion, MRH, which can be easily calculated in clinical practice, can be a useful marker to assess cardiovascular risk in patients with vitamin B12 deficiency.

Renal excretion of uric acid: Alterations during stressful underwater demolition team training.

1971 ◽  
Author(s):  
Leonard M. Zir ◽  
Robert T. Rubin ◽  
Richard H. Rahe ◽  
Ransom J. Arthur
Keyword(s):  
Uric Acid ◽  
Renal Excretion ◽  
Team Training
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