Poly(l-histidine) Based Triblock Copolymers: pH Induced Reassembly of Copolymer Micelles and Mechanism Underlying Endolysosomal Escape for Intracellular Delivery

2014 ◽  
Vol 15 (11) ◽  
pp. 4032-4045 ◽  
Author(s):  
Xiaojun Zhang ◽  
Dawei Chen ◽  
Shuang Ba ◽  
Jia Zhu ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Triblock Copolymers ◽  
Intracellular Delivery ◽  
Copolymer Micelles

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20025-20034 ◽  
Author(s):  
Yuling Li ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Yuling Shen ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Lipoic Acid ◽  
Triblock Copolymer ◽  
Intracellular Delivery ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Copolymer Poly

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

Self-assembled pH-responsive hyaluronic acid–g-poly(l-histidine) copolymer micelles for targeted intracellular delivery of doxorubicin

2014 ◽  
Vol 10 (5) ◽  
pp. 2024-2035 ◽  
Author(s):  
Lipeng Qiu ◽  
Zhen Li ◽  
Mingxi Qiao ◽  
Miaomiao Long ◽  
Mingyue Wang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Intracellular Delivery ◽  
Ph Responsive ◽  
Copolymer Micelles ◽  
Self Assembled

PEG-b-PCL Copolymer Micelles with the Ability of pH-Controlled Negative-to-Positive Charge Reversal for Intracellular Delivery of Doxorubicin

2014 ◽  
Vol 15 (11) ◽  
pp. 4281-4292 ◽  
Author(s):  
Hongzhang Deng ◽  
Jinjian Liu ◽  
Xuefei Zhao ◽  
Yuming Zhang ◽  
Jianfeng Liu ◽  
...  
Keyword(s):  
Positive Charge ◽  
Intracellular Delivery ◽  
Charge Reversal ◽  
Copolymer Micelles ◽  
Ph Controlled

Self-assembly of pH-responsive dextran-g-poly(lactide-co-glycolide)-g-histidine copolymer micelles for intracellular delivery of paclitaxel and its antitumor activity

RSC Advances ◽  
2016 ◽  
Vol 6 (28) ◽  
pp. 23693-23701 ◽  
Author(s):  
Jiulong Zhang ◽  
Kang Chen ◽  
Ying Ding ◽  
Xiu Xin ◽  
Wenpan Li ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Self Assembly ◽  
Intracellular Delivery ◽  
Antitumor Drugs ◽  
Ph Responsive ◽  
Copolymer Micelles

Herein, dextran (DX) was conjugated with poly(lactide-co-glycolide) (PLGA) and histidine (His) to prepare a pH-responsive nanocarrier, dextran-g-poly(lactide-co-glycolide)-g-histidine (HDP) micelles, for the delivery of antitumor drugs.

Tunable thermo-responsive P(NIPAAm-co-DMAAm)-b-PLLA-b-P(NIPAAm-co-DMAAm) triblock copolymer micelles as drug carriers

2014 ◽  
Vol 2 (18) ◽  
pp. 2738-2748 ◽  
Author(s):  
Yanfei Hu ◽  
Vincent Darcos ◽  
Sophie Monge ◽  
Suming Li ◽  
Yang Zhou ◽  
...  
Keyword(s):  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Ring Opening ◽  
Triblock Copolymer ◽  
Triblock Copolymers ◽  
Drug Carriers ◽  
Ring Opening Polymerization ◽  
Atom Transfer ◽  
Copolymer Micelles

Thermo-responsive P(NIPAAm-co-DMAAm)-b-PLLA-b-P(NIPAAm-co-DMAAm) triblock copolymers are synthesized via combination of ring-opening polymerization and atom transfer radical polymerization.

Interaction between bile salt sodium glycodeoxycholate and PEO–PPO–PEO triblock copolymers in aqueous solution

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 69313-69325 ◽  
Author(s):  
S. Bayati ◽  
C. Anderberg Haglund ◽  
N. V. Pavel ◽  
L. Galantini ◽  
K. Schillén
Keyword(s):  
Aqueous Solution ◽  
Molecular Weight ◽  
Block Copolymer ◽  
Bile Salt ◽  
Bile Salts ◽  
Triblock Copolymers ◽  
Block Length ◽  
Molar Ratio ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Bile salts can associate to PEO–PPO–PEO block copolymer micelles and disintegrate them depending on the relative block length and molecular weight of the copolymers and bile salt/copolymer molar ratio.

pH-Triggered copolymer micelles as drug nanocarriers for intracellular delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (35) ◽  
pp. 29149-29158 ◽  
Author(s):  
Weiju Hao ◽  
Danyang Liu ◽  
Yazhuo Shang ◽  
Junqi Zhang ◽  
Shouhong Xu ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Intracellular Delivery ◽  
Ph Sensitive ◽  
High Loading ◽  
Loading Capacity ◽  
Triggered Release ◽  
Copolymer Micelles ◽  
Drug Nanocarriers

We prepared pH-sensitive polymeric micelles which were used as nano-carriers and exhibited a high loading capacity and pH-triggered release of DOX.

Ketal Cross-Linked Poly(ethylene glycol)-Poly(amino acid)s Copolymer Micelles for Efficient Intracellular Delivery of Doxorubicin

2011 ◽  
Vol 12 (4) ◽  
pp. 1224-1233 ◽  
Author(s):  
Sang Jin Lee ◽  
Kyung Hyun Min ◽  
Hong Jae Lee ◽  
Ahn Na Koo ◽  
Hwa Pyeong Rim ◽  
...  
Keyword(s):  
Amino Acid ◽  
Ethylene Glycol ◽  
Intracellular Delivery ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Poly Ethylene

Nano-porous structuresviaself-assembly of amphiphilic triblock copolymers: influence of solvent and molecular weight

2018 ◽  
Vol 9 (2) ◽  
pp. 193-202 ◽  
Author(s):  
S. Nehache ◽  
M. Semsarilar ◽  
A. Deratani ◽  
M. In ◽  
P. Dieudonné-George ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Porous Materials ◽  
Self Assembly ◽  
Triblock Copolymer ◽  
Triblock Copolymers ◽  
Filtration Membranes ◽  
Copolymer Micelles ◽  
Aba Triblock Copolymer ◽  
Influence Of Solvent

Self-assembly of ABA triblock copolymer micelles into porous materials which are subsequently used as filtration membranes.

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