Cancer risk assessment guidelines delayed

1995 ◽  
Vol 29 (12) ◽  
pp. 537A-537A
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Cancer Risk Assessment ◽  
Assessment Guidelines

scholarly journals Cancer Risk Assessment and the Biostatistical Revolution of the 1970s—A Reflection

Dose-Response ◽  
2018 ◽  
Vol 16 (4) ◽  
pp. 155932581880640 ◽  
Author(s):  
Kenny Crump
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Environmental Protection Agency ◽  
Cancer Risk Assessment ◽  
Toxic Substances ◽  
Multistage Model ◽  
The Public ◽  
Cancer Data ◽  
Assessment Guidelines ◽  
Risk Of Cancer

Before around 1960, assessment of risk from exposure to toxic substances, including risk of cancer, was generally implemented using the NOAEL-safety factor approach that essentially assumed that an exposure threshold existed and exposures below the threshold carried no risk. In the 1970s there came a realization that cancer could develop from a mutation in a single cell and consequently it was unlikely that a threshold existed for substances that could cause such mutations, and that risk could increase linearly with exposure. During this time the Environmental Protection Agency (EPA) was formed and charged with protecting the public from a perceived high risk of environmental cancer. Faced with this difficult task, EPA decided to assess cancer risk by fitting a statistical model to dose-response cancer data and extrapolating to low dose using the fitted model. After some early experimentation EPA selected the Linearized Multistage Model for this fitting, which predicted risk increased linearly with exposure at low exposures. This approach led to an increased emphasis on statistical issues in risk assessment. Today, cancer risk assessment guidelines allow for different approaches depending upon the understanding of a substance's mode of action. However, a review of EPA's experience with current guidelines indicates that most cancer risk assessments still follow procedures similar to those initiated more than 40 years ago.

A Cancer Risk Assessment of Di(2-ethylhexyl)phthalate: Application of the New U.S. EPA Risk Assessment Guidelines

1999 ◽  
Vol 29 (3) ◽  
pp. 327-357 ◽  
Author(s):  
John Doull ◽  
Russell Cattley ◽  
Cliff Elcombe ◽  
Brian G. Lake ◽  
James Swenberg ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Cancer Risk Assessment ◽  
Assessment Guidelines ◽  
Ethylhexyl Phthalate

Risk assessment of ethyl carbamate in alcoholic beverages in Korea using the margin of exposure approach and cancer risk assessment

Food Control ◽  
2021 ◽  
Vol 124 ◽  
pp. 107867
Author(s):  
Sunghyeon Jung ◽  
Seungmin Kim ◽  
Inhwan Kim ◽  
Myung-Sub Chung ◽  
BoKyung Moon ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Ethyl Carbamate ◽  
Alcoholic Beverages ◽  
Cancer Risk Assessment ◽  
Margin Of Exposure

scholarly journals Towards radiologist-level cancer risk assessment in CT lung screening using deep learning

2021 ◽  
pp. 101883
Author(s):  
Stojan Trajanovski ◽  
Dimitrios Mavroeidis ◽  
Christine Leon Swisher ◽  
Binyam Gebrekidan Gebre ◽  
Bastiaan S. Veeling ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Deep Learning ◽  
Cancer Risk ◽  
Cancer Risk Assessment ◽  
Lung Screening
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