Polymer Micelle with Cross-Linked Ionic Core

2005 ◽  
Vol 127 (23) ◽  
pp. 8236-8237 ◽  
Author(s):  
Tatiana K. Bronich ◽  
Paul A. Keifer ◽  
Luda S. Shlyakhtenko ◽  
Alexander V. Kabanov
Keyword(s):  
Polymer Micelle ◽  
Ionic Core

Polymer–micelle interactions: physical organic aspects

1993 ◽  
Vol 22 (2) ◽  
pp. 85-92 ◽  
Author(s):  
Josephine C. Brackman ◽  
Jan B. F. N. Engberts
Keyword(s):  
Polymer Micelle ◽  
Physical Organic

Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems

2013 ◽  
Vol 1 (34) ◽  
pp. 4273 ◽  
Author(s):  
Jun Yue ◽  
Shi Liu ◽  
Zhigang Xie ◽  
Ying Xing ◽  
Xiabin Jing
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Antitumor Efficacy ◽  
Polymer Micelle ◽  
Size Dependent

scholarly journals Ionic Core−Shell Dendrimers with an Octacationic Core as Noncovalent Supports for Homogeneous Catalysts

2006 ◽  
Vol 128 (39) ◽  
pp. 12700-12713 ◽  
Author(s):  
Rob van de Coevering ◽  
Alfred P. Alfers ◽  
Johannes D. Meeldijk ◽  
Eloísa Martínez-Viviente ◽  
Paul S. Pregosin ◽  
...  
Keyword(s):  
Core Shell ◽  
Homogeneous Catalysts ◽  
Ionic Core

Abstract B22: IT-141, a stabilized polymer micelle formulation, prolongs the pharmacodynamic effect of SN-38

2016 ◽  
Author(s):  
Jyothi Sethuraman ◽  
Tara Lee Costich ◽  
Adam Carie ◽  
Taylor Buley ◽  
Tyler Ellis ◽  
...  
Keyword(s):  
Polymer Micelle ◽  
Pharmacodynamic Effect

Core hyper-cross-linked star polymers from block polymer micelle precursors

2020 ◽  
Vol 11 (45) ◽  
pp. 7178-7184
Author(s):  
Jongmin Park ◽  
Stefan J. D. Smith ◽  
Colin D. Wood ◽  
Xavier Mulet ◽  
Myungeun Seo
Keyword(s):  
Star Polymers ◽  
Cross Linking ◽  
Polymer Micelle ◽  
Polymer Micelles ◽  
Block Polymer

Hyper-cross-linking of a core of block polymer micelles produces core cross-linked polymer with a spacious hyper-cross-linked core, which is solution-processible.

scholarly journals A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Jonathan Rios-Doria ◽  
Adam Carie ◽  
Tara Costich ◽  
Brian Burke ◽  
Habib Skaff ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biological Fluids ◽  
Drug Carriers ◽  
Chemotherapeutic Drugs ◽  
Polymer Micelle ◽  
Drug Stabilization

Chemotherapeutic drugs are widely used for the treatment of cancer; however, use of these drugs is often associated with patient toxicity and poor tumor delivery. Micellar drug carriers offer a promising approach for formulating and achieving improved delivery of hydrophobic chemotherapeutic drugs; however, conventional micelles do not have long-term stability in complex biological environments such as plasma. To address this problem, a novel triblock copolymer has been developed to encapsulate several different hydrophobic drugs into stable polymer micelles. These micelles have been engineered to be stable at low concentrations even in complex biological fluids, and to release cargo in response to low pH environments, such as in the tumor microenvironment or in tumor cell endosomes. The particle sizes of drugs encapsulated ranged between 30–80 nm, with no relationship to the hydrophobicity of the drug. Stabilization of the micelles below the critical micelle concentration was demonstrated using a pH-reversible crosslinking mechanism, with proof-of-concept demonstrated in both in vitro and in vivo models. Described herein is polymer micelle drug delivery system that enables encapsulation and stabilization of a wide variety of chemotherapeutic drugs in a single platform.

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