Lithium Diisopropylamide-Mediated Ortholithiation and Anionic Fries Rearrangement of Aryl Carbamates:  Role of Aggregates and Mixed Aggregates

2006 ◽  
Vol 128 (42) ◽  
pp. 13753-13760 ◽  
Author(s):  
Kanwal Jit Singh ◽  
David B. Collum
Keyword(s):  
Lithium Diisopropylamide ◽  
Fries Rearrangement ◽  
Mixed Aggregates

scholarly journals Anionic Snieckus−Fries Rearrangement: Solvent Effects and Role of Mixed Aggregates

2008 ◽  
Vol 130 (41) ◽  
pp. 13709-13717 ◽  
Author(s):  
Jason C. Riggs ◽  
Kanwal J. Singh ◽  
Ma Yun ◽  
David B. Collum
Keyword(s):  
Solvent Effects ◽  
Fries Rearrangement ◽  
Mixed Aggregates

Polymorphonuclear Leukocyte-Platelet Interaction: Role of P-Selectin in Thromboxane B2 and Leukotriene C4 Cooperative Synthesis

1994 ◽  
Vol 72 (03) ◽  
pp. 450-456 ◽  
Author(s):  
Norma Maugeri ◽  
Virgilio Evangelista ◽  
Antonio Celardo ◽  
Giuseppe Dell’Elba ◽  
Nicola Martelli ◽  
...  
Keyword(s):  
Cell Aggregation ◽  
Inhibitory Effect ◽  
Cathepsin G ◽  
Cell Contact ◽  
Mixed Cell ◽  
Platelet Surface ◽  
Mixed Aggregates ◽  
Transcellular Metabolism ◽  
Cell Cell

SummaryIn PMN/platelet suspensions stimulated by fMLP giant mixed aggregates are formed and TxB2 and LTC4 are synthesized as the result of the cooperation in the arachidonic acid (AA) metabolism during cell/cell contact. PMN-derived cathepsin G induced the expression of P-selectin on platelet surface. GE12, an antibody against P-selectin, significantly reduced mixed cell aggregates. GE12 did not affect platelet aggregation induced by PMN-derived supernatants, indicating that the inhibitory effect of GE12 on mixed cell aggregation depends on inhibition of PMN/platelet adhesion. GE12 significantly reduced TxB2 and LTC4 production in PMN/platelet mixed cell suspensions stimulated by fMLP. As previously reported, synthesis of 3H-TxB2 in 3H-AA-labeled PMN/unlabeled platelets indicates that platelets utilize 3H-AA from PMN. 3H-LTC4 production in unlabeled PMN/3H-AA-labeled platelets indicates that bidirectional routes are utilized in this system for LTC4 synthesis. GE12 significantly reduced 3H-TxB2 and 3H-LTC4 synthesis. These results show that cathepsin G released by activated PMN induces the expression of P-selectin on platelet membrane: this adhesive glycoprotein modulates cell-cell contact and transcellular metabolism of AA.

Mechanism of Lithium Diisopropylamide-Mediated Ester Deprotonation:  The Role of Disolvated Monomers

1997 ◽  
Vol 119 (20) ◽  
pp. 4765-4766 ◽  
Author(s):  
Xiufeng Sun ◽  
Sarita L. Kenkre ◽  
Julius F. Remenar ◽  
James H. Gilchrist ◽  
David B. Collum
Keyword(s):  
Lithium Diisopropylamide
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