scholarly journals Visible-Light-Activated Quinolone Carbon-Monoxide-Releasing Molecule: Prodrug and Albumin-Assisted Delivery Enables Anticancer and Potent Anti-Inflammatory Effects

2018 ◽  
Vol 140 (30) ◽  
pp. 9721-9729 ◽  
Author(s):  
Marina Popova ◽  
Livia S. Lazarus ◽  
Suliman Ayad ◽  
Abby D. Benninghoff ◽  
Lisa M. Berreau
Keyword(s):  
Carbon Monoxide ◽  
Visible Light ◽  
Assisted Delivery ◽  
Anti Inflammatory

scholarly journals Carbon Monoxide Therapy Using Hybrid Carbon Monoxide-Releasing/Nrf2-Inducing Molecules through a Neuroprotective Lens

Chemistry ◽  
2021 ◽  
Vol 3 (3) ◽  
pp. 800-817
Author(s):  
Flavia Cavicchioli ◽  
Izzy M. Cesarotti ◽  
Madison Fangman ◽  
Josh Lua ◽  
Raymond Hautamaki ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Multiple Forms ◽  
Therapy Development ◽  
Anti Inflammatory ◽  
New Applications ◽  
Therapeutic Compound ◽  
Antioxidant Effects ◽  
Hybrid Carbon

Carbon monoxide (CO) has long been known for its toxicity. However, in recent decades, new applications for CO as a therapeutic compound have been proposed, and multiple forms of CO therapy have since been developed and studied. Previous research has found that CO has a role as a gasotransmitter and promotes anti-inflammatory and antioxidant effects, making it an avenue of interest for medicine. Such effects are possible because of the Nrf2/HO1 pathway, which has become a target for therapy development because its activation also leads to CO release. Currently, different forms of treatment involving CO include inhaled CO (iCO), carbon monoxide-releasing molecules (CORMs), and hybrid carbon monoxide-releasing molecules (HYCOs). In this article, we review the progression of CO studies to develop possible therapies, the possible mechanisms involved in the effects of CO, and the current forms of therapy using CO.

Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Neuroinflammation

2021 ◽  
Author(s):  
Daniela Dias-Pedroso ◽  
José S. Ramalho ◽  
Vilma A. Sardão ◽  
John G. Jones ◽  
Carlos C. Romão ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Oxygen Consumption ◽  
Inflammatory Response ◽  
Microglial Cell ◽  
Cell Metabolism ◽  
Competent Cell ◽  
Metabolic Shift ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Abstract Microglia are the immune competent cell of the central nervous system (CNS), promoting brain homeostasis and regulating inflammatory response against infection and injury. Chronic or exacerbated neuroinflammation is a cause of damage in several brain pathologies. Endogenous carbon monoxide (CO), produced from the degradation of heme, is described as anti-apoptotic and anti-inflammatory in several contexts, including in the CNS. Neuroglobin (Ngb) is a haemoglobin-homologous protein, which upregulation triggers antioxidant defence and prevents neuronal apoptosis. Thus, we hypothesized a crosstalk between CO and Ngb, in particular, that the anti-neuroinflammatory role of CO in microglia depends on Ngb. A novel CO-releasing molecule (ALF826) based on molybdenum was used for delivering CO in microglial culture.BV-2 mouse microglial cell line was challenged with lipopolysaccharide (LPS) for triggering inflammation, and after 6h ALF826 was added. CO exposure limited inflammation by decreasing inducible nitric oxide synthase (iNOS) expression and the production of nitric oxide (NO) and tumour necrosis factor-a (TNF-a), and by increasing interleukine-10 (IL-10) release. CO-induced Ngb upregulation correlated in time with CO’s anti-inflammatory effect. Moreover, knocking down Ngb reversed the anti-inflammatory effect of CO, suggesting that dependents on Ngb expression. CO-induced Ngb upregulation was independent on ROS signalling, but partially dependent on the transcriptional factor SP1. Finally, microglial cell metabolism is also involved in the inflammatory response. In fact, LPS treatment decreased oxygen consumption in microglia, indicating a switch to glycolysis, which is associated with a proinflammatory. While CO treatment increased oxygen consumption, reverting LPS effect and indicating a metabolic shift into a more oxidative metabolism. Moreover, in the absence of Ngb this phenotype was no longer observed, indicating Ngb is needed for CO’s modulation of microglial metabolism. Finally, the metabolic shift induced by CO did not depend on alteration of mitochondrial population. In conclusion, neuroglobin emerges for the first time as a key player for CO signalling against exacerbated neuroinflammation in microglia.

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

10.1038/74680 ◽  
2000 ◽  
Vol 6 (4) ◽  
pp. 422-428 ◽  
Author(s):  
Leo E. Otterbein ◽  
Fritz H. Bach ◽  
Jawed Alam ◽  
Miguel Soares ◽  
Hong Tao Lu ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Anti Inflammatory ◽  
Kinase Pathway

scholarly journals Carbon Monoxide Inhibits Cytokine and Chloride Secretion in Human Bronchial Epithelia

2018 ◽  
Vol 49 (2) ◽  
pp. 626-637 ◽  
Author(s):  
Rui-Gang Zhang ◽  
Chung-Yin Yip ◽  
Wing-hung Ko
Keyword(s):  
Carbon Monoxide ◽  
Ion Transport ◽  
Cell Damage ◽  
Chloride Secretion ◽  
Bronchial Epithelial Cell ◽  
Purinergic Signalling ◽  
Epithelial Cell Line ◽  
Cl Secretion ◽  
Bronchial Epithelia ◽  
Anti Inflammatory

Background/Aims: Carbon monoxide (CO) is an important gas produced endogenously by heme oxygenase (HO) that functions as an anti-inflammatory and in ion channel modulation, but the effects of CO on airway inflammation and ion transport remains unclear. Methods: The effect of CO on cell damage- and nucleotide-induced pro-inflammatory cytokine release in primary human bronchial epithelia cells (HBE) and in the 16HBE14o- human bronchial epithelial cell line were investigated. The effects of CO on calcium- and cAMP-dependent chloride (Cl-) secretion were examined using a technique that allowed the simultaneous measurement and quantification of real-time changes in signalling molecules (cAMP and Ca2+) and ion transport in a polarised epithelium. Results: CO suppressed the release of interleukin (IL)-6 and IL-8 and decreased the phosphorylation of ERK1/2 and NF-κB p65. Furthermore, CO inhibited UTP-induced increases in calcium and Cl- secretion, and forskolin-induced increases in cAMP and Cl- secretion. Conclusions: These findings suggest a novel anti-inflammatory role of CO in human bronchial epithelia via interactions with purinergic signalling pathways. Further, CO modulated both the Ca2+- and cAMP-dependent secretion of Cl-.

scholarly journals Atomically dispersed asymmetric Cu–B pair on 2D carbon nitride synergistically boosts the conversion of CO into C2 products

2020 ◽  
Vol 8 (2) ◽  
pp. 599-606 ◽  
Author(s):  
Tianwei He ◽  
Karsten Reuter ◽  
Aijun Du
Keyword(s):  
Carbon Monoxide ◽  
Visible Light ◽  
Carbon Nitride ◽  
Value Added ◽  
Dual Site

Asymmetric copper and boron dual-site synergy for boosting conversion of carbon monoxide into value-added C2 products under visible light.

scholarly journals Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study

2007 ◽  
Vol 30 (6) ◽  
pp. 1131-1137 ◽  
Author(s):  
E. Bathoorn ◽  
D-J. Slebos ◽  
D. S. Postma ◽  
G. H. Koeter ◽  
A. J. M. van Oosterhout ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Pilot Study ◽  
Anti Inflammatory

Carbon Monoxide Liberated from Carbon Monoxide-Releasing Molecule Exerts an Anti-inflammatory Effect on Dextran Sulfate Sodium-Induced Colitis in Mice

2010 ◽  
Vol 56 (6) ◽  
pp. 1663-1671 ◽  
Author(s):  
Tomohisa Takagi ◽  
Yuji Naito ◽  
Kazuhiko Uchiyama ◽  
Takahiro Suzuki ◽  
Ikuhiro Hirata ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals PhotoCORMs: CO release moves into the visible

2016 ◽  
Vol 45 (16) ◽  
pp. 6801-6811 ◽  
Author(s):  
Mark A. Wright ◽  
Joseph A. Wright
Keyword(s):  
Carbon Monoxide ◽  
Visible Light ◽  
Therapeutic Agent ◽  
Metal Carbonyls

The potential of carbon monoxide to act as a therapeutic agent is now well-established. In this Perspective, we examine the growth of photoCORMs from their origins in the photophysics of metal carbonyls to the latest visible-light agents.

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