A New Entry to Asymmetric Synthesis of Optically Active α,γ-Substituted γ-Butyrolactones, Using a Carbohydrate Derived Amide as Both a Chiral Auxiliary and a Proton Source

2005 ◽  
Vol 70 (2) ◽  
pp. 529-532 ◽  
Author(s):  
Ling-Lin Huang ◽  
Ming-Hua Xu ◽  
Guo-Qiang Lin
Keyword(s):  
Asymmetric Synthesis ◽  
Optically Active ◽  
Chiral Auxiliary ◽  
Proton Source ◽  
New Entry

A New Entry to Asymmetric Synthesis of 1-Substituted 1,2,3,4-Tetrahydro-β-carbolines Employing a Pyroglutamic Acid Derivative as a Chiral Auxiliary.

ChemInform ◽  
2002 ◽  
Vol 33 (40) ◽  
pp. 158-158
Author(s):  
Takashi Itoh ◽  
Kazuhiro Nagata ◽  
Masashi Yokoya ◽  
Michiko Miyazaki ◽  
Sachiko Ikeda ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Acid Derivative ◽  
Pyroglutamic Acid ◽  
Chiral Auxiliary ◽  
New Entry

scholarly journals Diastereoselective auxiliary- and catalyst-controlled intramolecular aza-Michael reaction for the elaboration of enantioenriched 3-substituted isoindolinones. Application to the synthesis of a new pazinaclone analogue

2018 ◽  
Vol 14 ◽  
pp. 593-602 ◽  
Author(s):  
Romain Sallio ◽  
Stéphane Lebrun ◽  
Frédéric Capet ◽  
Francine Agbossou-Niedercorn ◽  
Christophe Michon ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Michael Reaction ◽  
Phase Transfer ◽  
Benzodiazepine Receptor ◽  
Optically Active ◽  
Chiral Auxiliary ◽  
Phase Transfer Catalyst ◽  
Receptor Agonists ◽  
Michael Acceptor

A new asymmetric organocatalyzed intramolecular aza-Michael reaction by means of both a chiral auxiliary and a catalyst for stereocontrol is reported for the synthesis of optically active isoindolinones. A selected cinchoninium salt was used as phase-transfer catalyst in combination with a chiral nucleophile, a Michael acceptor and a base to provide 3-substituted isoindolinones in good yields and diastereomeric excesses. This methodology was applied to the asymmetric synthesis of a new pazinaclone analogue which is of interest in the field of benzodiazepine-receptor agonists.

A New Entry to Asymmetric Synthesis of 1-Substituted 1,2,3,4-Tetrahydro-β-carbolines Employing a Pyroglutamic Acid Derivative as a Chiral Auxiliary

Synlett ◽  
2002 ◽  
Vol 2002 (06) ◽  
pp. 1005-1007 ◽  
Author(s):  
Takashi Itoh ◽  
Kazuhiro Nagata ◽  
Masashi Yokoya ◽  
Michiko Miyazaki ◽  
Sachiko Ikeda ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Acid Derivative ◽  
Pyroglutamic Acid ◽  
Chiral Auxiliary ◽  
New Entry
Sign in / Sign up

Export Citation Format

Share Document